Titans– is set for Sunday, December 14, 2025 at 4:25 pm ET. Sportsbooks list Point Spread Titans and Total 44.5 M/L: Titans -901, 49ers +605 is available. Lines are posted across books.
Money Line-901+640
Spread
-12.5
-105
12.5
-105
Over/Under
-105
-112
Matchup Overview
Teams: 49ers vs Titans
Date: Sunday, December 14, 2025
Time: 04:25 pm ET
Venue: Levi's Stadium
Where To Watch 49ers vs Titans on Sunday
The match will be broadcast by FOX.
Injuries
49ers
Titans
Ameer Abdullah
– Ribs
Isaiah Prince
– Knee
Tre Tomlinson
– Undisclosed
Carter Bradley
– Undisclosed
Renardo Green
– Neck
Ricky Pearsall
– Knee
Deommodore Lenoir
– Hip
Kurtis Rourke
– Knee
Demarcus Robinson
– Suspended
Malik Mustapha
– Knee
Thomas Morstead
– Back
Mac Jones
– Knee
Brandon Aiyuk
– Knee
Brock Purdy
– Left Shoulder/Toe
Tanner Mordecai
– Undisclosed
Jauan Jennings
– Calf
Jordan Watkins
– Gameday Inactive
Jacob Cowing
– Hamstring
Upton Stout
– Calf
Tre Brown
– Heel
Christian McCaffrey
– Calf
Richie Grant
– Knee
Jason Pinnock
– Heel
Chase Lucas
– Gameday Inactive
Ji'Ayir Brown
– Hamstring
Darrell Luter Jr.
– Achilles
Jordan James
– Gameday Inactive
Eli Apple
– Gameday Inactive
Isaac Guerendo
– Back
Patrick Taylor Jr.
– Shoulder
Siran Neal
– Head
Dallis Flowers
– Gameday Inactive
Marques Sigle
– Gameday Inactive
Kyle Juszczyk
– Concussion
Nick Martin
– Gameday Inactive
Chazz Surratt
– Ankle
B.Huff
– Ankle
Tatum Bethune
– Thigh
Corey Kiner
– Undisclosed
Jakob Robinson
– Forearm
Robert Beal Jr.
– Gameday Inactive
Dee Winters
– Knee
Fred Warner
– Ankle
Drew Moss
– Gameday Inactive
Sebastian Valdez
– Gameday Inactive
Tarron Jackson
– Neck
Luke Gifford
– Knee
Curtis Robinson
– Knee
Austen Pleasants
– Gameday Inactive
Jake Brendel
– Hamstring
A.Dillard
– Undisclosed
Isaac Alarcon
– Suspension
Colton McKivitz
– Calf
Trent Williams
– Knee
Spencer Burford
– Knee
Connor Colby
– Gameday Inactive
Dominick Puni
– Knee
Ben Bartch
– Undisclosed
Trent Taylor
– Undisclosed
George Kittle
– Hamstring
Mason Pline
– Undisclosed
Kevin Givens
– Pectoral
Sam Okuayinonu
– Shoulder
Jordan Elliott
– Ankle
Kalia Davis
– Groin
Yetur Gross-Matos
– Undisclosed
Alfred Collins
– Knee
Nick Bosa
– Neck
Mykel Williams
– Knee
CJ West
– Knee
Treylon Burks
– Collarbone
Calvin Ridley
– General Soreness
Cam Ward
– Ankle/Calf
Tyjae Spears
– Ankle
Johnny Hekker
– Illness
Tyler Lockett
– Knee
Elic Ayomanor
– Hamstring
Joey Slye
– Right Calf
Oluwafemi Oladejo
– Calf
Will Levis
– Shoulder
Van Jefferson
– Ankle
Mason Kinsey
– Gameday Inactive
James Proche II
– Gameday Inactive
Chimere Dike
– Chest
Tony Pollard
– Neck
Roger McCreary
– Hip
Kevin Winston Jr.
– Hamstring
Julius Wood
– Suspension
Xavier Woods
– Ankle
Marcus Harris
– Calf
Kalel Mullings
– Ankle
Jarvis Brownlee Jr.
– Ankle
Kendell Brooks
– Concussion
Julius Chestnut
– Back
Amani Hooker
– Ribs
L'Jarius Sneed
– Knee/Quad
Darrell Baker Jr.
– Head
Mike Brown
– Knee
Dre'Mont Jones
– Knee
Arden Key
– Pectoral
C.Barton
– Personal
Cedric Gray
– Concussion
James Williams
– Gameday Inactive
Jihad Ward
– Personal
JC Latham
– Hip
Anfernee Orji
– ACL
John Ojukwu
– Gameday Inactive
Corey Levin
– Neck
Jackson Slater
– Gameday Inactive
Chandler Brewer
– Undisclosed
Sebastian Joseph-Day
– Calf
Kevin Zeitler
– Hamstring
Cam Horsley
– Gameday Inactive
Blake Hance
– Shoulder
Dan Moore Jr.
– Ankle
Brandon Crenshaw-Dickson
– Gameday Inactive
Lloyd Cushenberry III
– Achilles
Bryce Oliver
– Knee
Josh Whyle
– Concussion
Matt Landers
– Undisclosed
Gunnar Helm
– Toe
Chig Okonkwo
– Foot
Xavier Restrepo
– Ankle
Thomas Odukoya
– Gameday Inactive
T'Vondre Sweat
– Mouth
James Lynch
– Shoulder
Jeffery Simmons
– Ankle
Ali Gaye
– Knee
Current Betting Odds
Spread: Titans favored at 12.5
Total (Over/Under): 44.5
Moneyline Odds: 49ers -901 , Titans +605
Recent Matches
49ers
Titans
Date
Vs
Result
Score
11/30/2025
Browns
win
8 :
26
11/24/2025
Panthers
win
20
: 9
11/16/2025
Cardinals
win
22 :
41
11/09/2025
Rams
loss
26
: 42
11/02/2025
Giants
win
24 :
34
10/26/2025
Texans
loss
26 :
15
10/19/2025
Falcons
win
20
: 10
10/12/2025
Buccaneers
loss
30 :
19
10/02/2025
Rams
win
23 :
26
09/28/2025
Jaguars
loss
21
: 26
W - 6
L - 4
Date
Vs
Result
Score
12/07/2025
Browns
win
29 :
31
11/30/2025
Jaguars
loss
3
: 25
11/23/2025
Seahawks
loss
24
: 30
11/16/2025
Texans
loss
13
: 16
11/02/2025
Chargers
loss
20
: 27
10/26/2025
Colts
loss
38 :
14
10/19/2025
Patriots
loss
13
: 31
10/12/2025
Raiders
loss
20 :
10
10/05/2025
Cardinals
win
21 :
22
09/28/2025
Texans
loss
26 :
0
W - 2
L - 8
Who Wins: our Prediction
Based on statistical analysis, we see the 49ers at a win probability of 14%, while the Titans have a propability of 86% to win.
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