Buccaneers host Bills on Sunday, November 16, 2025. Books show Point Spread Buccaneers and O/U 46.5 ML: Buccaneers -283, Bills +232 is also posted. Numbers reflect current listings from sportsbooks.
Money Line-275+240
Spread
-6.5
-102
6.0
-105
Over/Under
-105
Matchup Overview
Teams: Bills vs Buccaneers
Date: Sunday, November 16, 2025
Time: 01:00 pm ET
Venue: Highmark Stadium
Where To Watch Bills vs Buccaneers on Sunday
The match will be broadcast by CBS.
Injuries
Bills
Buccaneers
Hayden Harris
– Hamstring
Keon Coleman
– Groin
Curtis Samuel
– Elbow
Tyler Bass
– Left Hip/Groin
Damar Hamlin
– Pectoral
James Cook
– Hamstring
Joshua Palmer
– Ankle
Taron Johnson
– Groin
Terrel Bernard
– Hamstring
Taylor Rapp
– Nose
Khalil Shakir
– Ankle
Mitchell Trubisky
– Illness
Jalen Virgil
– Undisclosed
Mike White
– Gameday Inactive
Josh Allen
– Right Elbow
Elijah Moore
– Personal
Darrynton Evans
– Undisclosed
Ray Davis
– Illness
Cole Bishop
– Cramping
Ty Johnson
– Ankle
Tre'Davious White
– Leg
Brandon Codrington
– Knee
Wande Owens
– Undisclosed
Maxwell Hairston
– Knee
Te'Cory Couch
– Hamstring
Jordan Hancock
– Shoulder
Cam Lewis
– Shoulder
Reggie Gilliam
– Knee
Dorian Williams
– Knee
Dorian Strong
– Neck
Shaq Thompson
– Hamstring/Hand
Ja'Marcus Ingram
– Gameday Inactive
Christian Benford
– Groin
Greg Rousseau
– Knee
Kendrick Green
– Gameday Inactive
Baylon Spector
– Undisclosed
Michael Hoecht
– Suspension
A.J. Epenesa
– Pectoral
Matt Milano
– Pectoral
Sedrick Van Pran-Granger
– Undisclosed
Connor McGovern
– Hamstring
Tylan Grable
– Undisclosed
Reid Ferguson
– Neck
Alec Anderson
– Knee
Marcus Harris
– Knee
Dion Dawkins
– Thumb
Chase Lundt
– Gameday Inactive
Spencer Brown
– Undisclosed
Tyrell Shavers
– Knee
Kaden Prather
– Hamstring
Jackson Hawes
– Ankle
Dalton Kincaid
– Hamstring
Dawson Knox
– Hip
DeWayne Carter
– Achilles
Ed Oliver
– Bicep
DaQuan Jones
– Calf
Landon Jackson
– Gameday Inactive
Deone Walker
– Ilness
Joey Bosa
– Hamstring
T.J. Sanders
– Knee
Larry Ogunjobi
– Gameday Inactive
Silas Dzansi
– Undisclosed
Marcus Banks
– Undisclosed
D.J. Williams
– Undisclosed
Jaden Smith
– Undisclosed
Rachaad White
– Groin
Anthony Walker
– Undisclosed
Chase McLaughlin
– Personal
Haason Reddick
– Personal
Baker Mayfield
– Knee/Right Biceps
Bucky Irving
– Foot/Shoulder
SirVocea Dennis
– Ankle
Connor Bazelak
– Gameday Inactive
Emeka Egbuka
– Hip/Groin
Trey Palmer
– Gameday Inactive
Michael Pratt
– Back
Mike Evans
– Collarbone/Concussion
Chris Godwin
– Undisclosed
Jalen McMillan
– Neck
Sterling Shepard
– Foot
Kameron Johnson
– Knee
Benjamin Morrison
– Hamstring
Kindle Vildor
– Gameday Inactive
Tykee Smith
– Ankle
Tyrek Funderburk
– Undisclosed
Jacob Parrish
– Oblique
Kaevon Merriweather
– Gameday Inactive
Zyon McCollum
– Neck/Shoulder
Christian Izien
– Oblique
Antoine Winfield Jr.
– Toe
Josh Hayes
– Ankle
Jamel Dean
– Groin
J.J. Roberts
– Knee
Josh Williams
– Gameday Inactive
Rashad Wisdom
– Gameday Inactive
Ko Kieft
– Head
Chris Braswell
– Foot
Sean Tucker
– Hand
Roman Parodie
– Undisclosed
Antonio Grier Jr.
– Undisclosed
Vita Vea
– Foot
David Walker
– Knee
C.J. Brewer
– Gameday Inactive
Lavonte David
– Knee
Desmond Watson
– Undisclosed
John Bullock
– Gameday Inactive
Markees Watts
– Personal
Michael Jordan
– Knee
Graham Barton
– Illness
Jake Majors
– Undisclosed
Luke Goedeke
– Foot
Ben Bredeson
– Shoulder
Cody Mauch
– Knee
Luke Haggard
– Shoulders
Tyler McLellan
– Undisclosed
Raiqwon O'Neal
– Undisclosed
Sua Opeta
– Undisclosed
Charlie Heck
– Knee
Tristan Wirfs
– Knee
Elijah Klein
– Gameday Inactive
Ryan Miller
– Gameday Inactive
Devin Culp
– Gameday Inactive
Tez Johnson
– Gameday Inactive
Cade Otton
– Leg
Logan Hall
– Groin
R.Dixon
– Personal
Calijah Kancey
– Pectoral
Greg Gaines
– Ankle
Anthony Nelson
– Illness
Current Betting Odds
Spread: Buccaneers favored at 6
Total (Over/Under): 46.5
Moneyline Odds: Bills -283 , Buccaneers +232
Recent Matches
Bills
Buccaneers
Date
Vs
Result
Score
11/09/2025
Dolphins
loss
30 :
13
11/02/2025
Chiefs
win
28
: 21
10/26/2025
Panthers
win
9 :
40
10/13/2025
Falcons
loss
24 :
14
10/05/2025
Patriots
loss
20
: 23
09/28/2025
Saints
win
31
: 19
09/18/2025
Dolphins
win
31
: 21
09/14/2025
Jets
win
10 :
30
09/07/2025
Ravens
win
41
: 40
08/23/2025
Buccaneers
win
19 :
23
W - 7
L - 3
Date
Vs
Result
Score
11/09/2025
Patriots
loss
23
: 28
10/26/2025
Saints
win
3 :
23
10/20/2025
Lions
loss
24 :
9
10/12/2025
49ers
win
30
: 19
10/05/2025
Seahawks
win
35 :
38
09/28/2025
Eagles
loss
25
: 31
09/21/2025
Jets
win
29
: 27
09/15/2025
Texans
win
19 :
20
09/07/2025
Falcons
win
20 :
23
08/23/2025
Bills
loss
19
: 23
W - 6
L - 4
Who Wins: our Prediction
Based on statistical analysis, we see the Bills at a win probability of 29%, while the Buccaneers have a propability of 71% to win.
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