On Sunday, October 12, 2025, Buccaneers face 49ers. The Point Spread is 49ers , while the Total is 47 M/L: 49ers -186, Buccaneers +157 is available. Sportsbetting sites have full lines listed.
Money Line-190+166
Spread
-3.5
-105
3.5
-105
Over/Under
-102
-118
Matchup Overview
Teams: Buccaneers vs 49ers
Date: Sunday, October 12, 2025
Time: 04:25 pm ET
Venue: Raymond James Stadium
Where To Watch Buccaneers vs 49ers on Sunday
Watch the full match on CBS.
Injuries
Buccaneers
49ers
Silas Dzansi
– Undisclosed
Marcus Banks
– Undisclosed
D.J. Williams
– Undisclosed
Jaden Smith
– Undisclosed
Rachaad White
– Groin
Anthony Walker
– Undisclosed
Haason Reddick
– Personal
Baker Mayfield
– Knee/Right Biceps
Bucky Irving
– Foot/Shoulder
SirVocea Dennis
– Ankle
Emeka Egbuka
– Hip/Groin
Trey Palmer
– Gameday Inactive
Michael Pratt
– Back
Mike Evans
– Collarbone/Concussion
Chris Godwin
– Undisclosed
Jalen McMillan
– Neck
Sterling Shepard
– Foot
Benjamin Morrison
– Hamstring
Kindle Vildor
– Gameday Inactive
Tykee Smith
– Ankle
Tyrek Funderburk
– Undisclosed
Jacob Parrish
– Oblique
Zyon McCollum
– Neck/Shoulder
Christian Izien
– Oblique
Antoine Winfield Jr.
– Toe
Josh Hayes
– Ankle
Jamel Dean
– Groin
J.J. Roberts
– Knee
Josh Williams
– Gameday Inactive
Rashad Wisdom
– Gameday Inactive
Ko Kieft
– Head
Sean Tucker
– Hand
Roman Parodie
– Undisclosed
Antonio Grier Jr.
– Undisclosed
Vita Vea
– Foot
David Walker
– Knee
C.J. Brewer
– Gameday Inactive
Lavonte David
– Knee
Desmond Watson
– Undisclosed
Markees Watts
– Personal
Michael Jordan
– Knee
Jake Majors
– Undisclosed
Luke Goedeke
– Foot
Ben Bredeson
– Shoulder
Cody Mauch
– Knee
Luke Haggard
– Shoulders
Tyler McLellan
– Undisclosed
Raiqwon O'Neal
– Undisclosed
Sua Opeta
– Undisclosed
Charlie Heck
– Knee
Tristan Wirfs
– Knee
Elijah Klein
– Gameday Inactive
Devin Culp
– Gameday Inactive
Tez Johnson
– Gameday Inactive
Cade Otton
– Leg
Logan Hall
– Groin
R.Dixon
– Personal
Calijah Kancey
– Pectoral
Greg Gaines
– Ankle
Ameer Abdullah
– Ribs
Isaiah Prince
– Knee
Tre Tomlinson
– Undisclosed
Carter Bradley
– Undisclosed
Renardo Green
– Neck
Ricky Pearsall
– Knee
Deommodore Lenoir
– Hip
Kurtis Rourke
– Knee
Demarcus Robinson
– Suspended
Malik Mustapha
– Knee
Thomas Morstead
– Back
Mac Jones
– Knee
Brandon Aiyuk
– Knee
Brock Purdy
– Left Shoulder/Toe
Tanner Mordecai
– Undisclosed
Jauan Jennings
– Calf
Jordan Watkins
– Ankle
Jacob Cowing
– Hamstring
Upton Stout
– Calf
Tre Brown
– Heel
Christian McCaffrey
– Calf
Richie Grant
– Knee
Jason Pinnock
– Heel
Darrell Luter Jr.
– Achilles
Jordan James
– Finger
Isaac Guerendo
– Back
Patrick Taylor Jr.
– Shoulder
Siran Neal
– Head
Marques Sigle
– Gameday Inactive
Kyle Juszczyk
– Concussion
Nick Martin
– Gameday Inactive
B.Huff
– Ankle
Tatum Bethune
– Thigh
Corey Kiner
– Undisclosed
Jakob Robinson
– Forearm
Robert Beal Jr.
– Gameday Inactive
Dee Winters
– Knee
Fred Warner
– Ankle
Drew Moss
– Gameday Inactive
Sebastian Valdez
– Gameday Inactive
Tarron Jackson
– Neck
Luke Gifford
– Knee
Curtis Robinson
– Knee
Austen Pleasants
– Gameday Inactive
Jake Brendel
– Hamstring
A.Dillard
– Undisclosed
Isaac Alarcon
– Suspension
Colton McKivitz
– Calf
Trent Williams
– Knee
Spencer Burford
– Knee
Connor Colby
– Groin
Dominick Puni
– Knee
Ben Bartch
– Undisclosed
Trent Taylor
– Undisclosed
George Kittle
– Hamstring
Mason Pline
– Undisclosed
Kevin Givens
– Pectoral
Sam Okuayinonu
– Shoulder
Jordan Elliott
– Ankle
Kalia Davis
– Groin
Yetur Gross-Matos
– Undisclosed
Alfred Collins
– Knee
Nick Bosa
– Neck
Mykel Williams
– Knee
CJ West
– Knee
Current Betting Odds
Spread: 49ers favored at 3.5
Total (Over/Under): 47
Moneyline Odds: Buccaneers -186 , 49ers +157
Recent Matches
Buccaneers
49ers
Date
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Result
Score
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: 23
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win
14 :
17
08/09/2025
Titans
win
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: 7
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loss
20
: 23
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win
27
: 19
W - 7
L - 3
Date
Vs
Result
Score
10/02/2025
Rams
win
23 :
26
09/28/2025
Jaguars
loss
21
: 26
09/21/2025
Cardinals
win
16
: 15
09/14/2025
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win
21 :
26
09/07/2025
Seahawks
win
13 :
17
08/23/2025
Chargers
win
30
: 23
08/16/2025
Raiders
win
19 :
22
08/09/2025
Broncos
loss
9
: 30
01/05/2025
Cardinals
loss
47 :
24
12/30/2024
Lions
loss
34
: 40
W - 6
L - 4
Who Wins: our Prediction
Based on statistical analysis, we see the Buccaneers at a win probability of 37%, while the 49ers have a propability of 63% to win.
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