The slate moves into Sunday with Seahawks at 49ers. Current point spread: Seahawks ; O/U: 43.5 ML: 49ers +114, Seahawks -134. Books list full pricing ahead of kickoff at 4:05 pm ET.
Money Line+114-125
Spread
1.5
-102
-2.5
-105
Over/Under
-104
Matchup Overview
Teams: Seahawks vs 49ers
Date: Sunday, September 07, 2025
Time: 04:05 pm ET
Venue: Lumen Field
Where To Watch Seahawks vs 49ers on Sunday
Watch the full match on FOX.
Injuries
Seahawks
49ers
DeMarcus Lawrence
– Quadricep
Marquez Valdes-Scantling
– Gameday Inactive
Drew Lock
– Personal
Nick Emmanwori
– Ankle
Jalen Milroe
– Gameday Inactive
Uchenna Nwosu
– Knee
Coby Bryant
– Knee
Kenneth Walker III
– Glute
Cooper Kupp
– Hamstring/Wrist
Jaxon Smith-Njigba
– Illness
Ernest Jones IV
– Shoulder
Sam Darnold
– Chest
Tory Horton
– Ankle
John Rhys Plumlee
– Undisclosed
Elijah Arroyo
– Groin
Jake Bobo
– Concussion
Julian Love
– Groin
Devon Witherspoon
– Knee
D'Anthony Bell
– Gameday Inactive
Shaquill Griffin
– Gameday Inactive
Kenny McIntosh
– Knee
Zach Charbonnet
– Foot
Riq Woolen
– Illness
Nehemiah Pritchett
– Hamstring
Josh Jobe
– Head
AJ Finley
– Knee
Jacardia Wright
– Undisclosed
Jerrick Reed II
– Gameday Inactive
Shemar Jean-Charles
– Undisclosed
George Holani
– Hamstring
Isas Waxter
– Knee
Brady Russell
– Wrist
Ty Okada
– Oblique
Robbie Ouzts
– Ankle
Drake Thomas
– Shoulder
Tyrice Knight
– Knee
Jared Ivey
– Gameday Inactive
Boye Mafe
– Toe
Connor O'Toole
– Gameday Inactive
Derick Hall
– Hip
Tyreke Smith
– Gameday Inactive
Jalen Sundell
– Ankle/Elbow
Christian Haynes
– Pectoral
Michael Jerrell
– Gameday Inactive
Charles Cross
– Finger
Abraham Lucas
– Elbow
Luke Felix-Fualalo
– Undisclosed
Josh Jones
– Ankle
Anthony Bradford
– Back
Grey Zabel
– Heel
Bryce Cabeldue
– Gameday Inactive
Mason Richman
– Gameday Inactive
Amari Kight
– Knee
Eric Saubert
– Calf
Cody White
– Shoulder
Dareke Young
– Hamstring
Tyrone Broden
– Undisclosed
AJ Barner
– Calf
Nick Kallerup
– Gameday Inactive
Jarran Reed
– Back
Quinton Bohanna
– Gameday Inactive
Mike Morris
– Concussion
Brandon Pili
– Knee
Johnathan Hankins
– Back
Rylie Mills
– Gameday Inactive
Leonard Williams
– Elbow/Shoulder
Ameer Abdullah
– Ribs
Isaiah Prince
– Knee
Tre Tomlinson
– Undisclosed
Carter Bradley
– Undisclosed
Renardo Green
– Neck
Ricky Pearsall
– Knee
Deommodore Lenoir
– Hip
Kurtis Rourke
– Knee
Demarcus Robinson
– Suspended
Malik Mustapha
– Knee
Thomas Morstead
– Back
Mac Jones
– Knee
Brandon Aiyuk
– Personal
Brock Purdy
– Left Shoulder/Toe
Tanner Mordecai
– Undisclosed
Jauan Jennings
– Calf
Jordan Watkins
– Gameday Inactive
Jacob Cowing
– Hamstring
Upton Stout
– Calf
Tre Brown
– Heel
Christian McCaffrey
– Calf
Richie Grant
– Knee
Jason Pinnock
– Heel
Chase Lucas
– Undisclosed
Ji'Ayir Brown
– Hamstring
Darrell Luter Jr.
– Achilles
Jordan James
– Gameday Inactive
Eli Apple
– Gameday Inactive
Isaac Guerendo
– Gameday Inactive
Patrick Taylor Jr.
– Shoulder
Siran Neal
– Head
Dallis Flowers
– Undisclosed
Marques Sigle
– Gameday Inactive
Kyle Juszczyk
– Concussion
Nick Martin
– Gameday Inactive
Chazz Surratt
– Ankle
B.Huff
– Ankle
Tatum Bethune
– Thigh
Corey Kiner
– Undisclosed
Jakob Robinson
– Forearm
Robert Beal Jr.
– Gameday Inactive
Dee Winters
– Knee
Fred Warner
– Ankle
Drew Moss
– Gameday Inactive
Sebastian Valdez
– Gameday Inactive
Tarron Jackson
– Neck
Luke Gifford
– Knee
Curtis Robinson
– Knee
Matt Hennessy
– Neck
Austen Pleasants
– Gameday Inactive
Jake Brendel
– Hamstring
A.Dillard
– Undisclosed
Isaac Alarcon
– Suspension
Colton McKivitz
– Calf
Trent Williams
– Knee
Spencer Burford
– Knee
Connor Colby
– Gameday Inactive
Dominick Puni
– Knee
Ben Bartch
– Undisclosed
Trent Taylor
– Undisclosed
George Kittle
– Achilles
Mason Pline
– Undisclosed
Kevin Givens
– Pectoral
Sam Okuayinonu
– Shoulder
Jordan Elliott
– Ankle
Kalia Davis
– Groin
Yetur Gross-Matos
– Undisclosed
Alfred Collins
– Shoulder
Jonathan Garvin
– Undisclosed
Nick Bosa
– Neck
Mykel Williams
– Knee
CJ West
– Knee
Current Betting Odds
Spread: Seahawks favored at 2
Total (Over/Under): 43.5
Moneyline Odds: Seahawks +114 , 49ers -134
Recent Matches
Seahawks
49ers
Date
Vs
Result
Score
08/23/2025
Packers
loss
20 :
7
08/15/2025
Chiefs
win
33
: 16
08/07/2025
Raiders
draw
23
: 23
01/05/2025
Rams
win
25 :
30
12/26/2024
Bears
win
3 :
6
12/22/2024
Vikings
loss
24
: 27
12/15/2024
Packers
loss
13
: 30
12/08/2024
Cardinals
win
18 :
30
12/01/2024
Jets
win
21 :
26
11/24/2024
Cardinals
win
16
: 6
W - 6
D - 1
L - 3
Date
Vs
Result
Score
08/23/2025
Chargers
win
30
: 23
08/16/2025
Raiders
win
19 :
22
08/09/2025
Broncos
loss
9
: 30
01/05/2025
Cardinals
loss
47 :
24
12/30/2024
Lions
loss
34
: 40
12/22/2024
Dolphins
loss
29 :
17
12/12/2024
Rams
loss
6
: 12
12/08/2024
Bears
win
38
: 13
12/01/2024
Bills
loss
35 :
10
11/24/2024
Packers
loss
38 :
10
W - 3
L - 7
Who Wins: our Prediction
Based on statistical analysis, we see the Seahawks at a win probability of 55%, while the 49ers have a propability of 45% to win.
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