Saints and 49ers meet Sunday, September 14, 2025, 1:00 pm ET. Vegas lists Point Spread Saints ; O/U 40.5 ML: 49ers +136, Saints -161 is posted. Pricing is consistent across leading sportsbooks.
Money Line+140-154
Spread
3.0
-110
-3.0
-104
Over/Under
-106
Matchup Overview
Teams: Saints vs 49ers
Date: Sunday, September 14, 2025
Time: 01:00 pm ET
Venue: Caesars Superdome
Where To Watch Saints vs 49ers on Sunday
The match will be broadcast by FOX.
Injuries
Saints
49ers
Shane Lemieux
– Undisclosed
Ugo Amadi
– Gameday Inactive
Alontae Taylor
– Groin
Spencer Rattler
– Right Finger
Kendre Miller
– Knee
Tyler Shough
– Hip
Taysom Hill
– Knee (ACL)
Cedrick Wilson Jr.
– Knee
Chris Olave
– Hip
Velus Jones Jr.
– Knee
Mason Tipton
– Undisclosed
Bub Means
– Ankle
Justin Reid
– Knee
Rashid Shaheed
– Leg
Rejzohn Wright
– Gameday Inactive
Cam Akers
– Gameday Inactive
Isaac Yiadom
– Hamstring
Julian Blackmon
– Labrum Tear
Devin Neal
– Gameday Inactive
Jordan Howden
– Oblique
Jonas Sanker
– Head
Rico Payton
– Leg
Alvin Kamara
– Ankle
J.T. Gray
– Hamstring
Zach Wood
– Hamstring
Khalen Saunders
– Gameday Inactive
Cesar Ruiz
– Ankle
D'Marco Jackson
– Hamstring
Jonah Williams
– Gameday Inactive
Demario Davis
– Calf
Jonathan Bullard
– Gameday Inactive
Nick Saldiveri
– Knee
Landon Young
– Ankle
Torricelli Simpkins III
– Gameday Inactive
Barry Wesley
– Gameday Inactive
Trevor Penning
– Toe
Taliese Fuaga
– Knee
Will Clapp
– Foot
Dillon Radunz
– Toe
Erik McCoy
– Biceps
Juwan Johnson
– Ankle
Foster Moreau
– Knee
Jack Stoll
– Toe
Chris Tyree
– Lower Body
Bryan Bresee
– ACL
Vernon Broughton
– Gameday Inactive
Nathan Shepherd
– Ankle/Knee
Cameron Jordan
– Groin
John Ridgeway III
– Gameday Inactive
Khristian Boyd
– Hand
Chris Rumph II
– Wrist
Chase Young
– Calf
Ameer Abdullah
– Ribs
Isaiah Prince
– Knee
Tre Tomlinson
– Undisclosed
Carter Bradley
– Undisclosed
Renardo Green
– Neck
Ricky Pearsall
– Knee
Deommodore Lenoir
– Hip
Kurtis Rourke
– Knee
Demarcus Robinson
– Suspended
Malik Mustapha
– Knee
Thomas Morstead
– Back
Mac Jones
– Knee
Brandon Aiyuk
– Personal
Brock Purdy
– Left Shoulder/Toe
Tanner Mordecai
– Undisclosed
Jauan Jennings
– Calf
Jordan Watkins
– Gameday Inactive
Jacob Cowing
– Hamstring
Upton Stout
– Calf
Tre Brown
– Heel
Christian McCaffrey
– Calf
Richie Grant
– Knee
Jason Pinnock
– Heel
Chase Lucas
– Undisclosed
Ji'Ayir Brown
– Hamstring
Darrell Luter Jr.
– Achilles
Jordan James
– Gameday Inactive
Eli Apple
– Gameday Inactive
Isaac Guerendo
– Gameday Inactive
Patrick Taylor Jr.
– Shoulder
Siran Neal
– Head
Dallis Flowers
– Undisclosed
Marques Sigle
– Gameday Inactive
Kyle Juszczyk
– Concussion
Nick Martin
– Gameday Inactive
Chazz Surratt
– Ankle
B.Huff
– Ankle
Tatum Bethune
– Thigh
Corey Kiner
– Undisclosed
Jakob Robinson
– Forearm
Robert Beal Jr.
– Gameday Inactive
Dee Winters
– Knee
Fred Warner
– Ankle
Drew Moss
– Gameday Inactive
Sebastian Valdez
– Gameday Inactive
Tarron Jackson
– Neck
Luke Gifford
– Knee
Curtis Robinson
– Knee
Matt Hennessy
– Neck
Austen Pleasants
– Gameday Inactive
Jake Brendel
– Hamstring
A.Dillard
– Undisclosed
Isaac Alarcon
– Suspension
Colton McKivitz
– Calf
Trent Williams
– Knee
Spencer Burford
– Knee
Connor Colby
– Gameday Inactive
Dominick Puni
– Knee
Ben Bartch
– Undisclosed
Trent Taylor
– Undisclosed
George Kittle
– Achilles
Mason Pline
– Undisclosed
Kevin Givens
– Pectoral
Sam Okuayinonu
– Shoulder
Jordan Elliott
– Ankle
Kalia Davis
– Groin
Yetur Gross-Matos
– Undisclosed
Alfred Collins
– Shoulder
Jonathan Garvin
– Undisclosed
Nick Bosa
– Neck
Mykel Williams
– Knee
CJ West
– Knee
Current Betting Odds
Spread: Saints favored at 3
Total (Over/Under): 40.5
Moneyline Odds: Saints +136 , 49ers -161
Recent Matches
Saints
49ers
Date
Vs
Result
Score
09/07/2025
Cardinals
loss
13
: 20
08/23/2025
Broncos
loss
19
: 28
08/17/2025
Jaguars
draw
17
: 17
08/10/2025
Chargers
loss
27 :
13
01/05/2025
Buccaneers
loss
27 :
19
12/29/2024
Raiders
loss
10
: 25
12/23/2024
Packers
loss
34 :
0
12/15/2024
Commanders
loss
19
: 20
12/08/2024
Giants
win
11 :
14
12/01/2024
Rams
loss
14
: 21
W - 1
D - 1
L - 8
Date
Vs
Result
Score
09/07/2025
Seahawks
win
13 :
17
08/23/2025
Chargers
win
30
: 23
08/16/2025
Raiders
win
19 :
22
08/09/2025
Broncos
loss
9
: 30
01/05/2025
Cardinals
loss
47 :
24
12/30/2024
Lions
loss
34
: 40
12/22/2024
Dolphins
loss
29 :
17
12/12/2024
Rams
loss
6
: 12
12/08/2024
Bears
win
38
: 13
12/01/2024
Bills
loss
35 :
10
W - 4
L - 6
Who Wins: our Prediction
Based on statistical analysis, we see the Saints at a win probability of 59%, while the 49ers have a propability of 41% to win.
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