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    Saints vs 49ers NFL Week 2 – Match Preview & Live Updates Sunday, September 14, 2025

    National Football League
    Saints
    Home
    14/09/2025
    1:00pm
    49ers
    Away
    Where To Watch Injuries Recent Matches Predicted Winner Futures Statistics

    Saints vs. 49ers: Detailed Breakdown

    Saints and 49ers meet Sunday, September 14, 2025, 1:00 pm ET. Vegas lists Point Spread Saints ; O/U 40.5 ML: 49ers +136, Saints -161 is posted. Pricing is consistent across leading sportsbooks.

    Money Line +140 DraftKings -154 FanDuel
    Spread 3.0 -110 DraftKings -3.0 -104 FanDuel
    Over/Under -106 FanDuel DraftKings

    Matchup Overview

    • Teams: Saints vs 49ers
    • Date: Sunday, September 14, 2025
    • Time: 01:00 pm ET
    • Venue: Caesars Superdome

    Where To Watch Saints vs 49ers on Sunday

    The match will be broadcast by FOX.

    Injuries

    Saints
    49ers
    Shane Lemieux
    – Undisclosed
    Ugo Amadi
    – Gameday Inactive
    Alontae Taylor
    – Groin
    Spencer Rattler
    – Right Finger
    Kendre Miller
    – Knee
    Tyler Shough
    – Hip
    Taysom Hill
    – Knee (ACL)
    Cedrick Wilson Jr.
    – Knee
    Chris Olave
    – Hip
    Velus Jones Jr.
    – Knee
    Mason Tipton
    – Ilness
    Bub Means
    – Ankle
    Justin Reid
    – Knee
    Rashid Shaheed
    – Leg
    Rejzohn Wright
    – Gameday Inactive
    Cam Akers
    – Gameday Inactive
    Isaac Yiadom
    – Hamstring
    Julian Blackmon
    – Labrum Tear
    Devin Neal
    – Gameday Inactive
    Jordan Howden
    – Oblique
    Jonas Sanker
    – Head
    Rico Payton
    – Hamstring
    Alvin Kamara
    – Ankle
    J.T. Gray
    – Hamstring
    Zach Wood
    – Hamstring
    Khalen Saunders
    – Gameday Inactive
    Cesar Ruiz
    – Ankle
    D'Marco Jackson
    – Hamstring
    Jonah Williams
    – Gameday Inactive
    Demario Davis
    – Calf
    Jonathan Bullard
    – Gameday Inactive
    Nick Saldiveri
    – Knee
    Landon Young
    – Ankle
    Torricelli Simpkins III
    – Gameday Inactive
    Barry Wesley
    – Gameday Inactive
    Trevor Penning
    – Toe
    Taliese Fuaga
    – Knee
    Will Clapp
    – Foot
    Dillon Radunz
    – Toe
    Erik McCoy
    – Biceps
    Juwan Johnson
    – Ankle
    Foster Moreau
    – Knee
    Jack Stoll
    – Toe
    Chris Tyree
    – Lower Body
    Bryan Bresee
    – Back
    Vernon Broughton
    – Gameday Inactive
    Nathan Shepherd
    – Ankle/Knee
    Cameron Jordan
    – Groin
    John Ridgeway III
    – Gameday Inactive
    Khristian Boyd
    – Hand
    Chris Rumph II
    – Wrist
    Chase Young
    – Calf
    Ameer Abdullah
    – Ribs
    Isaiah Prince
    – Knee
    Tre Tomlinson
    – Undisclosed
    Carter Bradley
    – Undisclosed
    Renardo Green
    – Neck
    Ricky Pearsall
    – Knee
    Deommodore Lenoir
    – Hip
    Kurtis Rourke
    – Knee
    Demarcus Robinson
    – Suspended
    Malik Mustapha
    – Knee
    Thomas Morstead
    – Back
    Mac Jones
    – Knee
    Brandon Aiyuk
    – Knee
    Brock Purdy
    – Left Shoulder/Toe
    Tanner Mordecai
    – Undisclosed
    Jauan Jennings
    – Calf
    Jordan Watkins
    – Gameday Inactive
    Jacob Cowing
    – Hamstring
    Upton Stout
    – Calf
    Tre Brown
    – Heel
    Christian McCaffrey
    – Calf
    Richie Grant
    – Knee
    Jason Pinnock
    – Heel
    Chase Lucas
    – Gameday Inactive
    Ji'Ayir Brown
    – Hamstring
    Darrell Luter Jr.
    – Achilles
    Jordan James
    – Gameday Inactive
    Eli Apple
    – Gameday Inactive
    Isaac Guerendo
    – Gameday Inactive
    Patrick Taylor Jr.
    – Shoulder
    Siran Neal
    – Head
    Dallis Flowers
    – Gameday Inactive
    Marques Sigle
    – Gameday Inactive
    Kyle Juszczyk
    – Concussion
    Nick Martin
    – Gameday Inactive
    Chazz Surratt
    – Ankle
    B.Huff
    – Ankle
    Tatum Bethune
    – Thigh
    Corey Kiner
    – Undisclosed
    Jakob Robinson
    – Forearm
    Robert Beal Jr.
    – Gameday Inactive
    Dee Winters
    – Knee
    Fred Warner
    – Ankle
    Drew Moss
    – Gameday Inactive
    Sebastian Valdez
    – Gameday Inactive
    Tarron Jackson
    – Neck
    Luke Gifford
    – Knee
    Curtis Robinson
    – Knee
    Austen Pleasants
    – Gameday Inactive
    Jake Brendel
    – Hamstring
    A.Dillard
    – Undisclosed
    Isaac Alarcon
    – Suspension
    Colton McKivitz
    – Calf
    Trent Williams
    – Knee
    Spencer Burford
    – Knee
    Connor Colby
    – Gameday Inactive
    Dominick Puni
    – Knee
    Ben Bartch
    – Undisclosed
    Trent Taylor
    – Undisclosed
    George Kittle
    – Hamstring
    Mason Pline
    – Undisclosed
    Kevin Givens
    – Pectoral
    Sam Okuayinonu
    – Shoulder
    Jordan Elliott
    – Ankle
    Kalia Davis
    – Groin
    Yetur Gross-Matos
    – Undisclosed
    Alfred Collins
    – Knee
    Nick Bosa
    – Neck
    Mykel Williams
    – Knee
    CJ West
    – Knee

    Current Betting Odds

    • Spread: Saints favored at 3
    • Total (Over/Under): 40.5
    • Moneyline Odds: Saints +136 , 49ers -161

    Recent Matches

    Saints
    49ers
    Date Vs Result Score
    09/07/2025 Cardinals loss 13 : 20
    08/23/2025 Broncos loss 19 : 28
    08/17/2025 Jaguars draw 17 : 17
    08/10/2025 Chargers loss 27 : 13
    01/05/2025 Buccaneers loss 27 : 19
    12/29/2024 Raiders loss 10 : 25
    12/23/2024 Packers loss 34 : 0
    12/15/2024 Commanders loss 19 : 20
    12/08/2024 Giants win 11 : 14
    12/01/2024 Rams loss 14 : 21
    W - 1
    D - 1
    L - 8
    Date Vs Result Score
    09/07/2025 Seahawks win 13 : 17
    08/23/2025 Chargers win 30 : 23
    08/16/2025 Raiders win 19 : 22
    08/09/2025 Broncos loss 9 : 30
    01/05/2025 Cardinals loss 47 : 24
    12/30/2024 Lions loss 34 : 40
    12/22/2024 Dolphins loss 29 : 17
    12/12/2024 Rams loss 6 : 12
    12/08/2024 Bears win 38 : 13
    12/01/2024 Bills loss 35 : 10
    W - 4
    L - 6

    Who Wins: our Prediction

    Based on statistical analysis, we see the Saints at a win probability of 59%, while the 49ers have a propability of 41% to win.

    Find the best Futures for Saints vs 49ers

    Statistics

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