49ers host Rams this Thursday at SoFi Stadium. Books show point spread (49ers ) and total sitting at 44. M/L: 49ers -444, Rams +351. Numbers reflect current sportsbook listings at the time of writing.
Money Line-450+350
Spread
-8.5
-102
7.5
-102
Over/Under
-110
Matchup Overview
Teams: Rams vs 49ers
Date: Thursday, October 02, 2025
Time: 08:15 pm ET
Venue: SoFi Stadium
Where To Watch Rams vs 49ers on Thursday
Watch the full match on AMZN.
Injuries
Rams
49ers
Byron Young
– Knee
Derion Kendrick
– Gameday Inactive
Jaylen McCollough
– Illness
Ahkello Witherspoon
– Knee
Tutu Atwell
– Gameday Inactive
Drake Stoops
– Suspension
Jared Verse
– Knee
Jimmy Garoppolo
– Back
Puka Nacua
– Ankle
Stetson Bennett
– Gameday Inactive
Konata Mumpfield
– Calf
Joshua Karty
– Gameday Inactive
Davante Adams
– Hamstring
Terrance Ferguson
– Gameday Inactive
Xavier Smith
– Concussion
Charles Woods
– Concussion/Groin
Blake Corum
– Ankle
Kyren Williams
– Ankle
Darious Williams
– Personal
Emmanuel Forbes Jr.
– Shoulder
Kamren Kinchens
– Shoulder
A.J. Green
– Gameday Inactive
Josh Wallace
– Knee
Nick Hampton
– Illness
Cody Schrader
– Gameday Inactive
Tanner Ingle
– Gameday Inactive
Jarquez Hunter
– Gameday Inactive
Quentin Lake
– Illness
Shaun Jolly
– Undisclosed
Josaiah Stewart
– Concussion
Brennan Jackson
– Gameday Inactive
Alex Ward
– Gameday Inactive
Omar Speights
– Ankle
Beaux Limmer
– Gameday Inactive
Nate Landman
– Calf
Braden Fiske
– Oblique
Shaun Dolac
– Knee
Ty Hamilton
– Gameday Inactive
Willie Lampkin
– Knee
Justin Dedich
– Gameday Inactive
David Quessenberry
– Gameday Inactive
Kevin Dotson
– Ankle
KT Leveston
– Gameday Inactive
D.J. Humphries
– Gameday Inactive
Steve Avila
– Ankle
Alaric Jackson
– Illness
Rob Havenstein
– Ankle
Colby Parkinson
– Shoulder
Davis Allen
– Knee
Jordan Whittington
– Knee
Tyler Higbee
– Hip
Kobie Turner
– Back
Desjuan Johnson
– Gameday Inactive
Poona Ford
– Elbow
Keir Thomas
– Undisclosed
Ameer Abdullah
– Ribs
Isaiah Prince
– Knee
Tre Tomlinson
– Undisclosed
Carter Bradley
– Undisclosed
Renardo Green
– Neck
Ricky Pearsall
– Knee
Deommodore Lenoir
– Hip
Kurtis Rourke
– Knee
Demarcus Robinson
– Suspended
Malik Mustapha
– Knee
Thomas Morstead
– Back
Mac Jones
– Knee
Brandon Aiyuk
– Personal
Brock Purdy
– Left Shoulder/Toe
Tanner Mordecai
– Undisclosed
Jauan Jennings
– Calf
Jordan Watkins
– Gameday Inactive
Jacob Cowing
– Hamstring
Upton Stout
– Calf
Tre Brown
– Heel
Christian McCaffrey
– Calf
Richie Grant
– Knee
Jason Pinnock
– Heel
Chase Lucas
– Undisclosed
Ji'Ayir Brown
– Hamstring
Darrell Luter Jr.
– Achilles
Jordan James
– Gameday Inactive
Eli Apple
– Gameday Inactive
Isaac Guerendo
– Gameday Inactive
Patrick Taylor Jr.
– Shoulder
Siran Neal
– Head
Dallis Flowers
– Undisclosed
Marques Sigle
– Gameday Inactive
Kyle Juszczyk
– Concussion
Nick Martin
– Gameday Inactive
Chazz Surratt
– Ankle
B.Huff
– Ankle
Tatum Bethune
– Thigh
Corey Kiner
– Undisclosed
Jakob Robinson
– Forearm
Robert Beal Jr.
– Gameday Inactive
Dee Winters
– Knee
Fred Warner
– Ankle
Drew Moss
– Gameday Inactive
Sebastian Valdez
– Gameday Inactive
Tarron Jackson
– Neck
Luke Gifford
– Knee
Curtis Robinson
– Knee
Matt Hennessy
– Neck
Austen Pleasants
– Gameday Inactive
Jake Brendel
– Hamstring
A.Dillard
– Undisclosed
Isaac Alarcon
– Suspension
Colton McKivitz
– Calf
Trent Williams
– Knee
Spencer Burford
– Knee
Connor Colby
– Gameday Inactive
Dominick Puni
– Knee
Ben Bartch
– Undisclosed
Trent Taylor
– Undisclosed
George Kittle
– Achilles
Mason Pline
– Undisclosed
Kevin Givens
– Pectoral
Sam Okuayinonu
– Shoulder
Jordan Elliott
– Ankle
Kalia Davis
– Groin
Yetur Gross-Matos
– Undisclosed
Alfred Collins
– Shoulder
Jonathan Garvin
– Undisclosed
Nick Bosa
– Neck
Mykel Williams
– Knee
CJ West
– Knee
Current Betting Odds
Spread: 49ers favored at 8.5
Total (Over/Under): 44
Moneyline Odds: Rams -444 , 49ers +351
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49ers
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: 40
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loss
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W - 5
L - 5
Who Wins: our Prediction
Based on statistical analysis, we see the Rams at a win probability of 21%, while the 49ers have a propability of 79% to win.
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