Rams vs 49ers NFL Week 5 – Match Preview & Live Updates Thursday, October 02, 2025

National Football League
Rams
Home
02/10/2025
8:15pm
49ers
Away

Rams vs. 49ers: Detailed Breakdown

49ers host Rams this Thursday at SoFi Stadium. Books show point spread (49ers ) and total sitting at 44. M/L: 49ers -444, Rams +351. Numbers reflect current sportsbook listings at the time of writing.

Money Line -450 DraftKings +350 DraftKings
Spread -8.5 -102 BetMGM 7.5 -102 DraftKings
Over/Under -110 Fanatics DraftKings

Matchup Overview

  • Teams: Rams vs 49ers
  • Date: Thursday, October 02, 2025
  • Time: 08:15 pm ET
  • Venue: SoFi Stadium

Where To Watch Rams vs 49ers on Thursday

Watch the full match on AMZN.

Injuries

Rams
49ers
Byron Young
– Knee
Derion Kendrick
– Gameday Inactive
Jaylen McCollough
– Illness
Ahkello Witherspoon
– Knee
Tutu Atwell
– Gameday Inactive
Drake Stoops
– Suspension
Jared Verse
– Knee
Jimmy Garoppolo
– Back
Puka Nacua
– Ankle
Stetson Bennett
– Gameday Inactive
Konata Mumpfield
– Calf
Joshua Karty
– Gameday Inactive
Davante Adams
– Hamstring
Terrance Ferguson
– Gameday Inactive
Xavier Smith
– Concussion
Charles Woods
– Concussion/Groin
Blake Corum
– Ankle
Kyren Williams
– Ankle
Darious Williams
– Personal
Emmanuel Forbes Jr.
– Shoulder
Kamren Kinchens
– Shoulder
A.J. Green
– Gameday Inactive
Josh Wallace
– Knee
Nick Hampton
– Illness
Cody Schrader
– Gameday Inactive
Tanner Ingle
– Gameday Inactive
Jarquez Hunter
– Gameday Inactive
Quentin Lake
– Illness
Shaun Jolly
– Undisclosed
Josaiah Stewart
– Concussion
Brennan Jackson
– Gameday Inactive
Alex Ward
– Gameday Inactive
Omar Speights
– Ankle
Beaux Limmer
– Gameday Inactive
Nate Landman
– Calf
Braden Fiske
– Oblique
Shaun Dolac
– Knee
Ty Hamilton
– Gameday Inactive
Willie Lampkin
– Knee
Justin Dedich
– Gameday Inactive
David Quessenberry
– Gameday Inactive
Kevin Dotson
– Ankle
KT Leveston
– Gameday Inactive
D.J. Humphries
– Gameday Inactive
Steve Avila
– Ankle
Alaric Jackson
– Illness
Rob Havenstein
– Ankle
Colby Parkinson
– Shoulder
Davis Allen
– Knee
Jordan Whittington
– Knee
Tyler Higbee
– Hip
Kobie Turner
– Back
Desjuan Johnson
– Gameday Inactive
Poona Ford
– Elbow
Keir Thomas
– Undisclosed
Ameer Abdullah
– Ribs
Isaiah Prince
– Knee
Tre Tomlinson
– Undisclosed
Carter Bradley
– Undisclosed
Renardo Green
– Neck
Ricky Pearsall
– Knee
Deommodore Lenoir
– Hip
Kurtis Rourke
– Knee
Demarcus Robinson
– Suspended
Malik Mustapha
– Knee
Thomas Morstead
– Back
Mac Jones
– Knee
Brandon Aiyuk
– Knee
Brock Purdy
– Left Shoulder/Toe
Tanner Mordecai
– Undisclosed
Jauan Jennings
– Calf
Jordan Watkins
– Gameday Inactive
Jacob Cowing
– Hamstring
Upton Stout
– Calf
Tre Brown
– Heel
Christian McCaffrey
– Calf
Richie Grant
– Knee
Jason Pinnock
– Heel
Chase Lucas
– Gameday Inactive
Ji'Ayir Brown
– Hamstring
Darrell Luter Jr.
– Achilles
Jordan James
– Gameday Inactive
Eli Apple
– Gameday Inactive
Isaac Guerendo
– Gameday Inactive
Patrick Taylor Jr.
– Shoulder
Siran Neal
– Head
Dallis Flowers
– Gameday Inactive
Marques Sigle
– Gameday Inactive
Kyle Juszczyk
– Concussion
Nick Martin
– Gameday Inactive
Chazz Surratt
– Ankle
B.Huff
– Ankle
Tatum Bethune
– Thigh
Corey Kiner
– Undisclosed
Jakob Robinson
– Forearm
Robert Beal Jr.
– Gameday Inactive
Dee Winters
– Knee
Fred Warner
– Ankle
Drew Moss
– Gameday Inactive
Sebastian Valdez
– Gameday Inactive
Tarron Jackson
– Neck
Luke Gifford
– Knee
Curtis Robinson
– Knee
Austen Pleasants
– Gameday Inactive
Jake Brendel
– Hamstring
A.Dillard
– Undisclosed
Isaac Alarcon
– Suspension
Colton McKivitz
– Calf
Trent Williams
– Knee
Spencer Burford
– Knee
Connor Colby
– Gameday Inactive
Dominick Puni
– Knee
Ben Bartch
– Undisclosed
Trent Taylor
– Undisclosed
George Kittle
– Hamstring
Mason Pline
– Undisclosed
Kevin Givens
– Pectoral
Sam Okuayinonu
– Shoulder
Jordan Elliott
– Ankle
Kalia Davis
– Groin
Yetur Gross-Matos
– Undisclosed
Alfred Collins
– Knee
Nick Bosa
– Neck
Mykel Williams
– Knee
CJ West
– Knee

Current Betting Odds

  • Spread: 49ers favored at 8.5
  • Total (Over/Under): 44
  • Moneyline Odds: Rams -444 , 49ers +351

Recent Matches

Rams
49ers
Date Vs Result Score
09/28/2025 Colts win 27 : 20
09/21/2025 Eagles loss 33 : 26
09/14/2025 Titans win 19 : 33
09/07/2025 Texans win 14 : 9
08/23/2025 Browns loss 19 : 17
08/16/2025 Chargers win 23 : 22
08/09/2025 Cowboys win 31 : 21
01/19/2025 Eagles loss 28 : 22
01/13/2025 Vikings win 27 : 9
01/05/2025 Seahawks loss 25 : 30
W - 6
L - 4
Date Vs Result Score
09/28/2025 Jaguars loss 21 : 26
09/21/2025 Cardinals win 16 : 15
09/14/2025 Saints win 21 : 26
09/07/2025 Seahawks win 13 : 17
08/23/2025 Chargers win 30 : 23
08/16/2025 Raiders win 19 : 22
08/09/2025 Broncos loss 9 : 30
01/05/2025 Cardinals loss 47 : 24
12/30/2024 Lions loss 34 : 40
12/22/2024 Dolphins loss 29 : 17
W - 5
L - 5

Who Wins: our Prediction

Based on statistical analysis, we see the Rams at a win probability of 21%, while the 49ers have a propability of 79% to win.

Find the best Futures for Rams vs 49ers

Statistics

Want Even More Picks To Profit From?
Money Line -116 FanDuel +100 BetMGM
Spread -1.5 -105 DraftKings 1.0 -110 BetMGM
Over/Under -102 FanDuel DraftKings
Money Line +176 FanDuel -200 BetMGM
Spread 3.5 -102 FanDuel -3.5 -105 BetMGM
Over/Under -108 DraftKings DraftKings
Money Line +130 DraftKings -152 FanDuel
Spread 3.0 -115 BetMGM -3.0 -102 DraftKings
Over/Under -108 DraftKings DraftKings
Money Line +455 DraftKings -592 FanDuel
Spread 10.0 -105 BetMGM -10.5 -104 FanDuel
Over/Under -110 BetMGM DraftKings
Money Line -120 BetMGM +106 FanDuel
Spread -1.5 -105 BetMGM 1.5 -110 FanDuel
Over/Under -108 FanDuel DraftKings
Money Line -180 DraftKings +154 BetMGM
Spread -3.5 +100 DraftKings 3.5 -115 BetMGM
Over/Under -110 FanDuel DraftKings
Money Line +135 BetMGM -150 Fanatics
Spread 2.5 -102 FanDuel -3.0 -102 BetMGM
Over/Under -108 FanDuel DraftKings
Money Line -1299 Fanatics +950 DraftKings
Spread -14.5 +100 FanDuel 14.0 -105 Fanatics
Over/Under -105 Fanatics DraftKings
Money Line -375 BetMGM +320 DraftKings
Spread -7.5 -105 BetMGM 7.5 -105 BetMGM
Over/Under -105 DraftKings DraftKings
Money Line -190 BetMGM +164 DraftKings
Spread -3.5 -105 DraftKings 3.5 -110 Fanatics
Over/Under -105 FanDuel DraftKings
Money Line +187.5 FanDuel -218 DraftKings
Spread 4.5 -114 FanDuel -4.5 -105 DraftKings
Over/Under -102 DraftKings DraftKings
Money Line +370 DraftKings -450 Fanatics
Spread 8.5 -105 FanDuel -8.5 -108 DraftKings
Over/Under -108 FanDuel DraftKings
Money Line +300 BetMGM -350 FanDuel
Spread 7.0 -102 FanDuel -7.5 +100 DraftKings
Over/Under -108 DraftKings DraftKings
Money Line +810 FanDuel -1000 BetMGM
Spread 13.5 -106 FanDuel -13.5 -105 DraftKings
Over/Under -105 DraftKings DraftKings
Money Line -115 Fanatics +102 FanDuel
Spread -1.5 -105 DraftKings 1.5 -110 FanDuel
Over/Under -110 FanDuel DraftKings
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