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    49ers vs Colts NFL Week 16 – Match Preview & Live Updates Monday, December 22, 2025

    National Football League
    Colts
    Home
    22/12/2025
    8:15pm
    49ers
    Away
    Where To Watch Injuries Recent Matches Predicted Winner Futures Statistics

    Colts vs. 49ers: Detailed Breakdown

    Colts vs 49ers is scheduled for Monday, December 22, 2025 at 8:15 pm ET. Point Spread: Colts ; O/U: 46.5 ML: 49ers +189, Colts -225. Lines are available across major sportsbetting sites.

    Money Line +187.5 FanDuel -218 DraftKings
    Spread 4.5 -114 FanDuel -4.5 -105 DraftKings
    Over/Under -102 DraftKings DraftKings

    Matchup Overview

    • Teams: Colts vs 49ers
    • Date: Monday, December 22, 2025
    • Time: 08:15 pm ET
    • Venue: Lucas Oil Stadium

    Where To Watch Colts vs 49ers on Monday

    Watch the full match on ESPN.

    Injuries

    Colts
    49ers
    Josh Downs
    – Hamstring
    D.J. Montgomery
    – Undisclosed
    Spencer Shrader
    – Knee
    Anthony Richardson Sr.
    – Eye
    Anthony Gould
    – Illness
    Charvarius Ward
    – Concussion
    Rigoberto Sanchez
    – Personal
    Adonai Mitchell
    – Gameday Inactive
    Michael Pittman Jr.
    – Glute
    Alec Pierce
    – Knee
    Riley Leonard
    – Gameday Inactive
    Ashton Dulin
    – Concussion
    Daniel Jones
    – Fibula
    Nick Cross
    – Hip
    DJ Giddens
    – Gameday Inactive
    Kenny Moore II
    – Calf
    Khalil Herbert
    – Gameday Inactive
    Justin Walley
    – Knee
    JuJu Brents
    – Gameday Inactive
    Hunter Wohler
    – Foot
    Tyler Goodson
    – Elbow
    Samuel Womack III
    – Gameday Inactive
    Johnathan Edwards
    – Gameday Inactive
    Salvon Ahmed
    – Ankle
    Daniel Scott
    – Knee
    Chris Lammons
    – Foot
    Jaylon Jones
    – Hamstring
    Zaire Franklin
    – Ankle
    Liam Anderson
    – Undisclosed
    Joe Bachie
    – Quadricep
    Maddux Trujillo
    – Undisclosed
    Kwity Paye
    – Groin
    Samson Ebukam
    – Back
    Jacob Phillips
    – Bicep
    Quenton Nelson
    – Wrist
    Jaylon Carlies
    – Ankle
    Austin Ajiake
    – Throat
    Cameron McGrone
    – Achilles
    Tanor Bortolini
    – Concussion
    Danny Pinter
    – Rib
    Luke Tenuta
    – Gameday Inactive
    Dalton Tucker
    – Shoulder
    Matt Goncalves
    – Personal
    Braden Smith
    – Groin
    Blake Freeland
    – Leg
    Jack Wilson
    – Undisclosed
    Bernhard Raimann
    – Illness
    Jelani Woods
    – Gameday Inactive
    Tyler Warren
    – Toe
    Drew Ogletree
    – Neck
    Will Mallory
    – Gameday Inactive
    Grover Stewart
    – Biceps
    JT Tuimoloau
    – Gameday Inactive
    Neville Gallimore
    – Knee
    Tyquan Lewis
    – Oblique
    Laiatu Latu
    – Hamstring
    Eric Johnson II
    – Gameday Inactive
    DeForest Buckner
    – Back
    Ameer Abdullah
    – Ribs
    Isaiah Prince
    – Knee
    Tre Tomlinson
    – Undisclosed
    Carter Bradley
    – Undisclosed
    Renardo Green
    – Neck
    Ricky Pearsall
    – Knee
    Deommodore Lenoir
    – Hip
    Kurtis Rourke
    – Knee
    Demarcus Robinson
    – Suspended
    Malik Mustapha
    – Knee
    Thomas Morstead
    – Back
    Mac Jones
    – Knee
    Brandon Aiyuk
    – Personal
    Brock Purdy
    – Left Shoulder/Toe
    Tanner Mordecai
    – Undisclosed
    Jauan Jennings
    – Calf
    Jordan Watkins
    – Gameday Inactive
    Jacob Cowing
    – Hamstring
    Upton Stout
    – Calf
    Tre Brown
    – Heel
    Christian McCaffrey
    – Calf
    Richie Grant
    – Knee
    Jason Pinnock
    – Heel
    Chase Lucas
    – Undisclosed
    Ji'Ayir Brown
    – Hamstring
    Darrell Luter Jr.
    – Achilles
    Jordan James
    – Gameday Inactive
    Eli Apple
    – Gameday Inactive
    Isaac Guerendo
    – Gameday Inactive
    Patrick Taylor Jr.
    – Shoulder
    Siran Neal
    – Head
    Dallis Flowers
    – Gameday Inactive
    Marques Sigle
    – Gameday Inactive
    Kyle Juszczyk
    – Concussion
    Nick Martin
    – Gameday Inactive
    Chazz Surratt
    – Ankle
    B.Huff
    – Ankle
    Tatum Bethune
    – Thigh
    Corey Kiner
    – Undisclosed
    Jakob Robinson
    – Forearm
    Robert Beal Jr.
    – Gameday Inactive
    Dee Winters
    – Knee
    Fred Warner
    – Ankle
    Drew Moss
    – Gameday Inactive
    Sebastian Valdez
    – Gameday Inactive
    Tarron Jackson
    – Neck
    Luke Gifford
    – Knee
    Curtis Robinson
    – Knee
    Matt Hennessy
    – Neck
    Austen Pleasants
    – Gameday Inactive
    Jake Brendel
    – Hamstring
    A.Dillard
    – Undisclosed
    Isaac Alarcon
    – Suspension
    Colton McKivitz
    – Calf
    Trent Williams
    – Knee
    Spencer Burford
    – Knee
    Connor Colby
    – Gameday Inactive
    Dominick Puni
    – Knee
    Ben Bartch
    – Undisclosed
    Trent Taylor
    – Undisclosed
    George Kittle
    – Achilles
    Mason Pline
    – Undisclosed
    Kevin Givens
    – Pectoral
    Sam Okuayinonu
    – Shoulder
    Jordan Elliott
    – Ankle
    Kalia Davis
    – Groin
    Yetur Gross-Matos
    – Undisclosed
    Alfred Collins
    – Shoulder
    Jonathan Garvin
    – Undisclosed
    Nick Bosa
    – Neck
    Mykel Williams
    – Knee
    CJ West
    – Knee

    Current Betting Odds

    • Spread: Colts favored at 4
    • Total (Over/Under): 46.5
    • Moneyline Odds: Colts +189 , 49ers -225

    Recent Matches

    Colts
    49ers
    Date Vs Result Score
    12/14/2025 Seahawks loss 18 : 16
    12/07/2025 Jaguars loss 36 : 19
    11/30/2025 Texans loss 16 : 20
    11/23/2025 Chiefs loss 23 : 20
    11/09/2025 Falcons win 31 : 25
    11/02/2025 Steelers loss 27 : 20
    10/26/2025 Titans win 38 : 14
    10/19/2025 Chargers win 24 : 38
    10/12/2025 Cardinals win 31 : 27
    10/05/2025 Raiders win 40 : 6
    W - 5
    L - 5
    Date Vs Result Score
    12/14/2025 Titans win 37 : 24
    11/30/2025 Browns win 8 : 26
    11/24/2025 Panthers win 20 : 9
    11/16/2025 Cardinals win 22 : 41
    11/09/2025 Rams loss 26 : 42
    11/02/2025 Giants win 24 : 34
    10/26/2025 Texans loss 26 : 15
    10/19/2025 Falcons win 20 : 10
    10/12/2025 Buccaneers loss 30 : 19
    10/02/2025 Rams win 23 : 26
    W - 7
    L - 3

    Who Wins: our Prediction

    Based on statistical analysis, we see the Colts at a win probability of 67%, while the 49ers have a propability of 33% to win.

    Find the best Futures for Colts vs 49ers

    Statistics

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    All Betting Tips
    Money Line -116 FanDuel +100 BetMGM
    Spread -1.5 -105 DraftKings 1.0 -110 BetMGM
    Over/Under -102 FanDuel DraftKings
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    Spread 3.5 -102 FanDuel -3.5 -105 BetMGM
    Over/Under -108 DraftKings DraftKings
    Money Line +130 DraftKings -152 FanDuel
    Spread 3.0 -115 BetMGM -3.0 -102 DraftKings
    Over/Under -108 DraftKings DraftKings
    Money Line +455 DraftKings -592 FanDuel
    Spread 10.0 -105 BetMGM -10.5 -104 FanDuel
    Over/Under -110 BetMGM DraftKings
    Money Line -180 DraftKings +154 BetMGM
    Spread -3.5 +100 DraftKings 3.5 -115 BetMGM
    Over/Under -110 FanDuel DraftKings
    Money Line +135 BetMGM -150 Fanatics
    Spread 2.5 -102 FanDuel -3.0 -102 BetMGM
    Over/Under -108 FanDuel DraftKings
    Money Line -1299 Fanatics +950 DraftKings
    Spread -14.5 +100 FanDuel 14.0 -105 Fanatics
    Over/Under -105 Fanatics DraftKings
    Money Line -375 BetMGM +320 DraftKings
    Spread -7.5 -105 BetMGM 7.5 -105 BetMGM
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    Money Line -190 BetMGM +164 DraftKings
    Spread -3.5 -105 DraftKings 3.5 -110 Fanatics
    Over/Under -105 FanDuel DraftKings
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    Spread 4.5 -114 FanDuel -4.5 -105 DraftKings
    Over/Under -102 DraftKings DraftKings
    Money Line +370 DraftKings -450 Fanatics
    Spread 8.5 -105 FanDuel -8.5 -108 DraftKings
    Over/Under -108 FanDuel DraftKings
    Money Line +300 BetMGM -350 FanDuel
    Spread 7.0 -102 FanDuel -7.5 +100 DraftKings
    Over/Under -108 DraftKings DraftKings
    Money Line +810 FanDuel -1000 BetMGM
    Spread 13.5 -106 FanDuel -13.5 -105 DraftKings
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    Money Line -115 Fanatics +102 FanDuel
    Spread -1.5 -105 DraftKings 1.5 -110 FanDuel
    Over/Under -110 FanDuel DraftKings
    Money Line -140 BetMGM +120 DraftKings
    Spread -2.5 -105 BetMGM 2.5 -105 DraftKings
    Over/Under -105 DraftKings DraftKings
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