Browns vs 49ers is scheduled for Sunday, November 30, 2025 at 1:00 pm ET. Point Spread: Browns ; O/U: 35.5 ML: 49ers +210, Browns -254. Lines are available across major sportsbetting sites.
Money Line+220-235
Spread
5.0
-105
-5.0
-105
Over/Under
-105
Matchup Overview
Teams: Browns vs 49ers
Date: Sunday, November 30, 2025
Time: 01:00 pm ET
Venue: Huntington Bank Field
Where To Watch Browns vs 49ers on Sunday
The match will be broadcast by CBS.
Injuries
Browns
49ers
Greg Newsome II
– Shoulder
Martin Emerson Jr.
– Achilles
DeAndre Carter
– Knee
Jerry Jeudy
– Knee
Deshaun Watson
– Achilles
Dillon Gabriel
– Concussion
Jeremiah Owusu-Koramoah
– Neck
K.Pickett
– Hamstring
Grant Delpit
– Back
Quinshon Judkins
– Not Injury Related
Shedeur Sanders
– Gameday Inactive
Corey Bojorquez
– Right Ankle
Joe Flacco
– Right Shoulder/Right Finger
Jerome Baker
– Achilles
David Bell
– Undisclosed
Cedric Tillman
– Thumb
Pierre Strong Jr.
– Undisclosed
Denzel Ward
– Shoulder
Dylan Sampson
– Calf
Damontae Kazee
– Gameday Inactive
Myles Harden
– Ankle
Rayshawn Jenkins
– Wrist
Cameron Mitchell
– Gameday Inactive
Devin Bush
– Foot
Cade McDonald
– Undisclosed
Jerome Ford
– Shoulder
Dom Jones
– Knee
Nathaniel Watson
– Biceps
Easton Mascarenas-Arnold
– Achilles
Mohamoud Diabate
– Quad
Anthony Kendall
– Undisclosed
Andre Szmyt
– Left Calf
Carson Schwesinger
– Ankle
Mike Hall Jr.
– Undisclosed
Julian Okwara
– Undisclosed
Ethan Pocic
– Knee
Isaiah McGuire
– Knee
Winston Reid
– Back
Adin Huntington
– Concussion
Lorenzo Thompson
– Undisclosed
Zak Zinter
– Gameday Inactive
Cornelius Lucas
– Ankle
Teven Jenkins
– Shoulder
Joel Bitonio
– Back
Wyatt Teller
– Calf
Jack Conklin
– Elbow
Dawand Jones
– Knee
Jamari Thrash
– Gameday Inactive
Brenden Bates
– Gameday Inactive
Gage Larvadain
– Gameday Inactive
David Njoku
– Knee
Blake Whiteheart
– Knee
Harold Fannin Jr.
– Hamstring
Joe Tryon-Shoyinka
– Gameday Inactive
Alex Wright
– Quad
Sam Kamara
– Gameday Inactive
Shelby Harris
– Illness
Mason Graham
– Shoulder
Myles Garrett
– Ankle
Maliek Collins
– Quadricep
Ameer Abdullah
– Ribs
Isaiah Prince
– Knee
Tre Tomlinson
– Undisclosed
Carter Bradley
– Undisclosed
Renardo Green
– Neck
Ricky Pearsall
– Knee
Deommodore Lenoir
– Hip
Kurtis Rourke
– Knee
Demarcus Robinson
– Suspended
Malik Mustapha
– Knee
Thomas Morstead
– Back
Mac Jones
– Knee
Brandon Aiyuk
– Personal
Brock Purdy
– Left Shoulder/Toe
Tanner Mordecai
– Undisclosed
Jauan Jennings
– Calf
Jordan Watkins
– Gameday Inactive
Jacob Cowing
– Hamstring
Upton Stout
– Calf
Tre Brown
– Heel
Christian McCaffrey
– Calf
Richie Grant
– Knee
Jason Pinnock
– Heel
Chase Lucas
– Undisclosed
Ji'Ayir Brown
– Hamstring
Darrell Luter Jr.
– Achilles
Jordan James
– Gameday Inactive
Eli Apple
– Gameday Inactive
Isaac Guerendo
– Gameday Inactive
Patrick Taylor Jr.
– Shoulder
Siran Neal
– Head
Dallis Flowers
– Undisclosed
Marques Sigle
– Gameday Inactive
Kyle Juszczyk
– Concussion
Nick Martin
– Gameday Inactive
Chazz Surratt
– Ankle
B.Huff
– Ankle
Tatum Bethune
– Thigh
Corey Kiner
– Undisclosed
Jakob Robinson
– Forearm
Robert Beal Jr.
– Gameday Inactive
Dee Winters
– Knee
Fred Warner
– Ankle
Drew Moss
– Gameday Inactive
Sebastian Valdez
– Gameday Inactive
Tarron Jackson
– Neck
Luke Gifford
– Knee
Curtis Robinson
– Knee
Matt Hennessy
– Neck
Austen Pleasants
– Gameday Inactive
Jake Brendel
– Hamstring
A.Dillard
– Undisclosed
Isaac Alarcon
– Suspension
Colton McKivitz
– Calf
Trent Williams
– Knee
Spencer Burford
– Knee
Connor Colby
– Gameday Inactive
Dominick Puni
– Knee
Ben Bartch
– Undisclosed
Trent Taylor
– Undisclosed
George Kittle
– Achilles
Mason Pline
– Undisclosed
Kevin Givens
– Pectoral
Sam Okuayinonu
– Shoulder
Jordan Elliott
– Ankle
Kalia Davis
– Groin
Yetur Gross-Matos
– Undisclosed
Alfred Collins
– Shoulder
Jonathan Garvin
– Undisclosed
Nick Bosa
– Neck
Mykel Williams
– Knee
CJ West
– Knee
Current Betting Odds
Spread: Browns favored at 5.5
Total (Over/Under): 35.5
Moneyline Odds: Browns +210 , 49ers -254
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win
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: 9
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win
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loss
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: 42
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34
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: 10
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30 :
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23 :
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: 26
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win
16
: 15
W - 6
L - 4
Who Wins: our Prediction
Based on statistical analysis, we see the Browns at a win probability of 69%, while the 49ers have a propability of 31% to win.
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