The slate moves into Sunday with Cardinals at 49ers. Current point spread: Cardinals ; O/U: 48.5 ML: 49ers +158, Cardinals -187. Books list full pricing ahead of kickoff at 4:05 pm ET.
Money Line+160-190
Spread
3.5
-105
-3.5
-105
Over/Under
-106
Matchup Overview
Teams: Cardinals vs 49ers
Date: Sunday, November 16, 2025
Time: 04:05 pm ET
Venue: State Farm Stadium
Where To Watch Cardinals vs 49ers on Sunday
Watch the full match on FOX.
Injuries
Cardinals
49ers
Will Johnson
– Groin
Kyler Murray
– Illness
Mack Wilson Sr.
– Ankle
Budda Baker
– Hamstring
Greg Dortch
– Collarbone
Baron Browning
– Concussion
James Conner
– Ankle
BJ Ojulari
– Undisclosed
J.Sweat
– Knee
Blake Gillikin
– Back
Kei'Trel Clark
– Gameday Inactive
Michael Wilson
– Foot
Quez Watkins
– Undisclosed
Max Melton
– Hamstring
Zay Jones
– Knee
Marvin Harrison Jr.
– Concussion
DeeJay Dallas
– Gameday Inactive
Garrett Williams
– Achilles
Sean Murphy-Bunting
– Knee
Starling Thomas V
– Knee
Zaven Collins
– Hand
Jammie Robinson
– Gameday Inactive
Akeem Davis-Gaither
– Elbow
Elijah Jones
– Gameday Inactive
Denzel Burke
– Knee
Darren Hall
– Ankle
Emari Demercado
– Ankle
Joey Blount
– Neck
Trey Benson
– Knee
Jalen Thompson
– Hamstring
Bam Knight
– Gameday Inactive
Kitan Crawford
– Ankle
Jaylon Jones
– Hamstring
Dadrion Taylor-Demerson
– Ankle
Owen Pappoe
– Quadricep
Cody Simon
– Concussion
J.J. Russell
– Concussion
Xavier Thomas
– Gameday Inactive
Dante Stills
– Heel
Darius Robinson
– Chest
Hayden Conner
– Gameday Inactive
Jon Gaines II
– Thumb
Evan Brown
– Hamstring
Jeremiah Byers
– Gameday Inactive
Kelvin Beachum
– Knee
Valentin Senn
– Neck
Paris Johnson Jr.
– Knee
Hjalte Froholdt
– Elbow
Jonah Williams
– Foot
Christian Jones
– Knee
Josh Fryar
– Gameday Inactive
PJ Mustipher
– Foot
Simi Fehoko
– Concussion
Travis Vokolek
– Gameday Inactive
Andre Baccellia
– Arm
Elijah Higgins
– Illness
Trishton Jackson
– Thumb
Tip Reiman
– Ankle
Xavier Weaver
– Gameday Inactive
L.J. Collier
– Knee
Bilal Nichols
– Undisclosed
Dalvin Tomlinson
– Knee
Elijah Simmons
– Gameday Inactive
Walter Nolen III
– Calf
Justin Jones
– Knee
Ameer Abdullah
– Ribs
Isaiah Prince
– Knee
Tre Tomlinson
– Undisclosed
Carter Bradley
– Undisclosed
Renardo Green
– Neck
Ricky Pearsall
– Knee
Deommodore Lenoir
– Hip
Kurtis Rourke
– Knee
Demarcus Robinson
– Suspended
Malik Mustapha
– Knee
Thomas Morstead
– Back
Mac Jones
– Knee
Brandon Aiyuk
– Personal
Brock Purdy
– Left Shoulder/Toe
Tanner Mordecai
– Undisclosed
Jauan Jennings
– Calf
Jordan Watkins
– Gameday Inactive
Jacob Cowing
– Hamstring
Upton Stout
– Calf
Tre Brown
– Heel
Christian McCaffrey
– Calf
Richie Grant
– Knee
Jason Pinnock
– Heel
Chase Lucas
– Undisclosed
Ji'Ayir Brown
– Hamstring
Darrell Luter Jr.
– Achilles
Jordan James
– Gameday Inactive
Eli Apple
– Gameday Inactive
Isaac Guerendo
– Gameday Inactive
Patrick Taylor Jr.
– Shoulder
Siran Neal
– Head
Dallis Flowers
– Undisclosed
Marques Sigle
– Gameday Inactive
Kyle Juszczyk
– Concussion
Nick Martin
– Gameday Inactive
Chazz Surratt
– Ankle
B.Huff
– Ankle
Tatum Bethune
– Thigh
Corey Kiner
– Undisclosed
Jakob Robinson
– Forearm
Robert Beal Jr.
– Gameday Inactive
Dee Winters
– Knee
Fred Warner
– Ankle
Drew Moss
– Gameday Inactive
Sebastian Valdez
– Gameday Inactive
Tarron Jackson
– Neck
Luke Gifford
– Knee
Curtis Robinson
– Knee
Matt Hennessy
– Neck
Austen Pleasants
– Gameday Inactive
Jake Brendel
– Hamstring
A.Dillard
– Undisclosed
Isaac Alarcon
– Suspension
Colton McKivitz
– Calf
Trent Williams
– Knee
Spencer Burford
– Knee
Connor Colby
– Gameday Inactive
Dominick Puni
– Knee
Ben Bartch
– Undisclosed
Trent Taylor
– Undisclosed
George Kittle
– Achilles
Mason Pline
– Undisclosed
Kevin Givens
– Pectoral
Sam Okuayinonu
– Shoulder
Jordan Elliott
– Ankle
Kalia Davis
– Groin
Yetur Gross-Matos
– Undisclosed
Alfred Collins
– Shoulder
Jonathan Garvin
– Undisclosed
Nick Bosa
– Neck
Mykel Williams
– Knee
CJ West
– Knee
Current Betting Odds
Spread: Cardinals favored at 3.5
Total (Over/Under): 48.5
Moneyline Odds: Cardinals +158 , 49ers -187
Recent Matches
Cardinals
49ers
Date
Vs
Result
Score
11/09/2025
Seahawks
loss
44 :
22
11/03/2025
Cowboys
win
17 :
27
10/19/2025
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loss
23
: 27
10/12/2025
Colts
loss
31 :
27
10/05/2025
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loss
21
: 22
09/25/2025
Seahawks
loss
20
: 23
09/21/2025
49ers
loss
16 :
15
09/14/2025
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win
27
: 22
09/07/2025
Saints
win
13 :
20
08/23/2025
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win
20
: 10
W - 4
L - 6
Date
Vs
Result
Score
11/09/2025
Rams
loss
26
: 42
11/02/2025
Giants
win
24 :
34
10/26/2025
Texans
loss
26 :
15
10/19/2025
Falcons
win
20
: 10
10/12/2025
Buccaneers
loss
30 :
19
10/02/2025
Rams
win
23 :
26
09/28/2025
Jaguars
loss
21
: 26
09/21/2025
Cardinals
win
16
: 15
09/14/2025
Saints
win
21 :
26
09/07/2025
Seahawks
win
13 :
17
W - 6
L - 4
Who Wins: our Prediction
Based on statistical analysis, we see the Cardinals at a win probability of 63%, while the 49ers have a propability of 37% to win.
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