For Cardinals at Seahawks on Thursday, September 25, 2025, sportsbooks post Point Spread Cardinals with O/U 43.5 ML: Seahawks +103, Cardinals -123 appears on boards. Kickoff is 8:15 pm ET. Lines are live at books.
Money Line+114-120
Spread
1.5
-102
-1.5
-102
Over/Under
-105
Matchup Overview
Teams: Cardinals vs Seahawks
Date: Thursday, September 25, 2025
Time: 08:15 pm ET
Venue: State Farm Stadium
Where To Watch Cardinals vs Seahawks on Thursday
Watch the full match on AMZN.
Injuries
Cardinals
Seahawks
Will Johnson
– Groin
Kyler Murray
– Illness
Mack Wilson Sr.
– Ankle
Budda Baker
– Hamstring
Greg Dortch
– Collarbone
Baron Browning
– Concussion
James Conner
– Ankle
BJ Ojulari
– Undisclosed
J.Sweat
– Knee
Blake Gillikin
– Back
Kei'Trel Clark
– Gameday Inactive
Michael Wilson
– Foot
Quez Watkins
– Undisclosed
Max Melton
– Hamstring
Zay Jones
– Knee
Marvin Harrison Jr.
– Concussion
DeeJay Dallas
– Gameday Inactive
Garrett Williams
– Achilles
Sean Murphy-Bunting
– Knee
Starling Thomas V
– Knee
Zaven Collins
– Hand
Jammie Robinson
– Gameday Inactive
Akeem Davis-Gaither
– Elbow
Elijah Jones
– Gameday Inactive
Denzel Burke
– Knee
Darren Hall
– Ankle
Emari Demercado
– Ankle
Joey Blount
– Neck
Trey Benson
– Knee
Jalen Thompson
– Hamstring
Bam Knight
– Gameday Inactive
Kitan Crawford
– Ankle
Jaylon Jones
– Hamstring
Dadrion Taylor-Demerson
– Ankle
Owen Pappoe
– Quadricep
Cody Simon
– Concussion
J.J. Russell
– Concussion
Xavier Thomas
– Gameday Inactive
Dante Stills
– Heel
Darius Robinson
– Chest
Hayden Conner
– Gameday Inactive
Jon Gaines II
– Thumb
Evan Brown
– Hamstring
Jeremiah Byers
– Gameday Inactive
Kelvin Beachum
– Knee
Valentin Senn
– Neck
Paris Johnson Jr.
– Knee
Hjalte Froholdt
– Elbow
Jonah Williams
– Foot
Christian Jones
– Knee
Josh Fryar
– Gameday Inactive
PJ Mustipher
– Foot
Simi Fehoko
– Concussion
Travis Vokolek
– Gameday Inactive
Andre Baccellia
– Arm
Elijah Higgins
– Illness
Trishton Jackson
– Thumb
Tip Reiman
– Ankle
Xavier Weaver
– Gameday Inactive
L.J. Collier
– Knee
Bilal Nichols
– Undisclosed
Dalvin Tomlinson
– Knee
Elijah Simmons
– Gameday Inactive
Walter Nolen III
– Calf
Justin Jones
– Knee
DeMarcus Lawrence
– Quadricep
Marquez Valdes-Scantling
– Gameday Inactive
Drew Lock
– Personal
Nick Emmanwori
– Ankle
Jalen Milroe
– Gameday Inactive
Uchenna Nwosu
– Knee
Coby Bryant
– Knee
Kenneth Walker III
– Glute
Cooper Kupp
– Hamstring/Wrist
Jaxon Smith-Njigba
– Illness
Ernest Jones IV
– Shoulder
Sam Darnold
– Chest
Tory Horton
– Ankle
John Rhys Plumlee
– Undisclosed
Elijah Arroyo
– Groin
Jake Bobo
– Concussion
Julian Love
– Groin
Devon Witherspoon
– Knee
D'Anthony Bell
– Gameday Inactive
Shaquill Griffin
– Gameday Inactive
Kenny McIntosh
– Knee
Zach Charbonnet
– Foot
Riq Woolen
– Illness
Nehemiah Pritchett
– Hamstring
Josh Jobe
– Head
AJ Finley
– Knee
Jacardia Wright
– Undisclosed
Jerrick Reed II
– Gameday Inactive
Shemar Jean-Charles
– Undisclosed
George Holani
– Hamstring
Isas Waxter
– Knee
Brady Russell
– Wrist
Ty Okada
– Oblique
Robbie Ouzts
– Ankle
Drake Thomas
– Shoulder
Tyrice Knight
– Knee
Jared Ivey
– Gameday Inactive
Boye Mafe
– Toe
Connor O'Toole
– Gameday Inactive
Derick Hall
– Hip
Tyreke Smith
– Gameday Inactive
Jalen Sundell
– Ankle/Elbow
Christian Haynes
– Pectoral
Michael Jerrell
– Gameday Inactive
Charles Cross
– Finger
Abraham Lucas
– Elbow
Luke Felix-Fualalo
– Undisclosed
Josh Jones
– Ankle
Anthony Bradford
– Back
Grey Zabel
– Heel
Bryce Cabeldue
– Gameday Inactive
Mason Richman
– Gameday Inactive
Amari Kight
– Knee
Eric Saubert
– Calf
Cody White
– Shoulder
Dareke Young
– Hamstring
Tyrone Broden
– Undisclosed
AJ Barner
– Calf
Nick Kallerup
– Gameday Inactive
Jarran Reed
– Back
Quinton Bohanna
– Gameday Inactive
Mike Morris
– Concussion
Brandon Pili
– Knee
Johnathan Hankins
– Back
Rylie Mills
– Gameday Inactive
Leonard Williams
– Elbow/Shoulder
Current Betting Odds
Spread: Cardinals favored at 1.5
Total (Over/Under): 43.5
Moneyline Odds: Cardinals +103 , Seahawks -123
Recent Matches
Cardinals
Seahawks
Date
Vs
Result
Score
09/21/2025
49ers
loss
16 :
15
09/14/2025
Panthers
win
27
: 22
09/07/2025
Saints
win
13 :
20
08/23/2025
Raiders
win
20
: 10
08/16/2025
Broncos
loss
27 :
7
08/09/2025
Chiefs
win
20
: 17
01/05/2025
49ers
win
47
: 24
12/28/2024
Rams
loss
13 :
9
12/22/2024
Panthers
loss
36 :
30
12/15/2024
Patriots
win
30
: 17
W - 6
L - 4
Date
Vs
Result
Score
09/21/2025
Saints
win
44
: 13
09/14/2025
Steelers
win
17 :
31
09/07/2025
49ers
loss
13
: 17
08/23/2025
Packers
loss
20 :
7
08/15/2025
Chiefs
win
33
: 16
08/07/2025
Raiders
draw
23
: 23
01/05/2025
Rams
win
25 :
30
12/26/2024
Bears
win
3 :
6
12/22/2024
Vikings
loss
24
: 27
12/15/2024
Packers
loss
13
: 30
W - 5
D - 1
L - 4
Who Wins: our Prediction
Based on statistical analysis, we see the Cardinals at a win probability of 53%, while the Seahawks have a propability of 47% to win.
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