For Patriots at Steelers on Sunday, September 21, 2025, sportsbooks post Point Spread Patriots with O/U 44.5 ML: Steelers -106, Patriots -112 appears on boards. Kickoff is 1:00 pm ET. Lines are live at books.
Money Line+100-110
Spread
1.0
-110
-1.5
-105
Over/Under
-104
Matchup Overview
Teams: Patriots vs Steelers
Date: Sunday, September 21, 2025
Time: 01:00 pm ET
Venue: Gillette Stadium
Where To Watch Patriots vs Steelers on Sunday
Watch the full match on CBS.
Injuries
Patriots
Steelers
Yasir Durant
– Undisclosed
Christian Gonzalez
– Concussion
Ja'Lynn Polk
– Shoulder
Harold Landry III
– Foot
DeMario Douglas
– Hamstring
Antonio Gibson
– Knee
Jabrill Peppers
– Quadricep
Carlton Davis III
– Achilles
Stefon Diggs
– Knee
Kayshon Boutte
– Shoulder
Drake Maye
– Right Shoulder
Mack Hollins
– Hand
Robert Spillane
– Hand
Marte Mapu
– Neck
Kobee Minor
– Gameday Inactive
Jaylinn Hawkins
– Hamstring
Marcus Epps
– Shoulder
Kyle Dugger
– Knee
Marcus Jones
– Elbow
Terrell Jennings
– Undisclosed
Marcellas Dial Jr.
– ACL
Alex Austin
– Undisclosed
Jeremiah Webb
– Undisclosed
DJ James
– Undisclosed
Craig Woodson
– Ankle
TreVeyon Henderson
– Shoulder
Anfernee Jennings
– Knee
Lan Larison
– Undisclosed
Rhamondre Stevenson
– Toe
Brenden Schooler
– Undisclosed
Bradyn Swinson
– Gameday Inactive
K'Lavon Chaisson
– Knee
Brock Lampe
– Undisclosed
Jahlani Tavai
– Calf
Jack Gibbens
– Hamstring
Marcus Bryant
– Gameday Inactive
Christian Elliss
– Shoulder
Jared Wilson
– Thigh
Vederian Lowe
– Undisclosed
Layden Robinson
– Undisclosed
Garrett Bradbury
– Illness
Will Campbell
– Ankle
Isaiah Iton
– Hip
Caedan Wallace
– Gameday Inactive
Mike Onwenu
– Shoulder
Demontrey Jacobs
– Gameday Inactive
Morgan Moses
– Knee
Gee Scott Jr.
– Undisclosed
Austin Hooper
– Undisclosed
CJ Dippre
– Illness
Kendrick Bourne
– Rib
Hunter Henry
– Knee
Efton Chism III
– Knee
Jack Westover
– Hamstring
Christian Barmore
– Personal
Elijah Ponder
– Gameday Inactive
Joshua Farmer
– Ankle
Jaquelin Roy
– Undisclosed
Khyiris Tonga
– Knee
M.Williams
– Ankle
Keion White
– Illness
Donald Parham Jr.
– Achilles
Jacob Slade
– Undisclosed
DK Metcalf
– Ankle
Jalen Ramsey
– Knee
Cameron Johnston
– Leg
Patrick Queen
– Hip
Aaron Rodgers
– Left Wrist
Roman Wilson
– Gameday Inactive
Brandon Johnson
– Undisclosed
Scotty Miller
– Gameday Inactive
Ben Skowronek
– Illness
Skylar Thompson
– Undisclosed
Will Howard
– Hand
Calvin Austin III
– Abdomen
Kaleb Johnson
– Gameday Inactive
Chuck Clark
– Gameday Inactive
D.Slay Jr.
– Gameday Inactive
Joey Porter Jr.
– Hamstring
DeShon Elliott
– Personal
Brandin Echols
– Ankle
Cory Trice Jr.
– Hamstring
Miles Killebrew
– Knee
Sebastian Castro
– Gameday Inactive
Jaylen Warren
– Knee
Beanie Bishop Jr.
– Suspended
Donte Kent
– Knee
Devin Harper
– Undisclosed
James Pierre
– Concussion
Christian Kuntz
– Chest
Malik Harrison
– Knee
Nick Herbig
– Hamstring
Zach Frazier
– Calf
Cole Holcomb
– Illness
Alex Highsmith
– Ankle
Max Scharping
– Gameday Inactive
Calvin Anderson
– Illness
Domenique Davis
– Undisclosed
Gareth Warren
– Concussion
Esezi Otomewo
– Gameday Inactive
Isaac Seumalo
– Pectoral
Troy Fautanu
– Personal
Broderick Jones
– Groin
Yahya Black
– Shoulder
Darnell Washington
– Foot
Jonnu Smith
– Knee
Connor Heyward
– Knee
Ke'Shawn Williams
– Concussion
Pat Freiermuth
– Quadricep
T.J. Watt
– Hip
Logan Lee
– Gameday Inactive
Isaiahh Loudermilk
– Ankle
Dean Lowry
– Knee
Keeanu Benton
– Upper Body
Daniel Ekuale
– Knee
Cameron Heyward
– Knee
DeMarvin Leal
– Gameday Inactive
Derrick Harmon
– Knee
Current Betting Odds
Spread: Patriots favored at 0.5
Total (Over/Under): 44.5
Moneyline Odds: Patriots -106 , Steelers -112
Recent Matches
Patriots
Steelers
Date
Vs
Result
Score
09/14/2025
Dolphins
win
27 :
33
09/07/2025
Raiders
loss
13
: 20
08/21/2025
Giants
loss
42 :
10
08/16/2025
Vikings
win
12 :
20
08/08/2025
Commanders
win
48
: 18
01/05/2025
Bills
win
23
: 16
12/28/2024
Chargers
loss
7
: 40
12/22/2024
Bills
loss
24 :
21
12/15/2024
Cardinals
loss
30 :
17
12/01/2024
Colts
loss
24
: 25
W - 4
L - 6
Date
Vs
Result
Score
09/14/2025
Seahawks
loss
17
: 31
09/07/2025
Jets
win
32 :
34
08/21/2025
Panthers
win
10 :
19
08/16/2025
Buccaneers
loss
14
: 17
08/09/2025
Jaguars
win
25 :
31
01/11/2025
Ravens
loss
28 :
14
01/04/2025
Bengals
loss
17
: 19
12/25/2024
Chiefs
loss
10
: 29
12/21/2024
Ravens
loss
34 :
17
12/15/2024
Eagles
loss
27 :
13
W - 3
L - 7
Who Wins: our Prediction
Based on statistical analysis, we see the Patriots at a win probability of 51%, while the Steelers have a propability of 49% to win.
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