On Sunday, December 28, 2025, Bills face Eagles. The Point Spread is Eagles , while the Total is 44.5 M/L: Eagles -167, Bills +141 is available. Sportsbetting sites have full lines listed.
Money Line-160+142
Spread
-3.0
-110
3.0
-105
Over/Under
-105
Matchup Overview
Teams: Bills vs Eagles
Date: Sunday, December 28, 2025
Time: 04:25 pm ET
Venue: Highmark Stadium
Where To Watch Bills vs Eagles on Sunday
Watch the full match on FOX.
Injuries
Bills
Eagles
Hayden Harris
– Hamstring
Keon Coleman
– Groin
Curtis Samuel
– Elbow
Tyler Bass
– Left Hip/Groin
Damar Hamlin
– Pectoral
James Cook
– Hamstring
Joshua Palmer
– Ankle
Taron Johnson
– Groin
Terrel Bernard
– Hamstring
Taylor Rapp
– Nose
Khalil Shakir
– Ankle
Mitchell Trubisky
– Illness
Jalen Virgil
– Undisclosed
Mike White
– Gameday Inactive
Josh Allen
– Right Elbow
Elijah Moore
– Personal
Darrynton Evans
– Undisclosed
Ray Davis
– Illness
Cole Bishop
– Cramping
Daequan Hardy
– Undisclosed
Ty Johnson
– Ankle
Tre'Davious White
– Leg
Darrick Forrest
– Undisclosed
Brandon Codrington
– Knee
Wande Owens
– Undisclosed
Maxwell Hairston
– Knee
Te'Cory Couch
– Hamstring
Jordan Hancock
– Shoulder
Cam Lewis
– Shoulder
Reggie Gilliam
– Knee
Dorian Williams
– Knee
Dorian Strong
– Neck
Shaq Thompson
– Hamstring/Hand
Ja'Marcus Ingram
– Gameday Inactive
Christian Benford
– Groin
Greg Rousseau
– Knee
Kendrick Green
– Undisclosed
Baylon Spector
– Undisclosed
Michael Hoecht
– Suspension
A.J. Epenesa
– Pectoral
Matt Milano
– Pectoral
Sedrick Van Pran-Granger
– Undisclosed
Connor McGovern
– Hamstring
Tylan Grable
– Undisclosed
Reid Ferguson
– Neck
Alec Anderson
– Knee
Marcus Harris
– Knee
Dion Dawkins
– Thumb
Chase Lundt
– Gameday Inactive
Spencer Brown
– Undisclosed
Tyrell Shavers
– Knee
Kaden Prather
– Hamstring
Jackson Hawes
– Ankle
Dalton Kincaid
– Hamstring
Dawson Knox
– Hip
DeWayne Carter
– Achilles
Ed Oliver
– Bicep
DaQuan Jones
– Calf
Landon Jackson
– Gameday Inactive
Deone Walker
– Ilness
Joey Bosa
– Hamstring
T.J. Sanders
– Knee
Larry Ogunjobi
– Gameday Inactive
Joshua Uche
– Groin
Jahan Dotson
– Toe
Nolan Smith Jr.
– Triceps
DeVonta Smith
– Groin
Adoree' Jackson
– Groin
A.J. Brown
– Hamstring
Azeez Ojulari
– Gameday Inactive
Tanner McKee
– Thumb
Nakobe Dean
– Knee
Mac McWilliams
– Gameday Inactive
Andrew Mukuba
– Hamstring
Saquon Barkley
– Knee
Quinyon Mitchell
– Hamstring
Will Shipley
– Oblique
A.J. Dillon
– Gameday Inactive
Jihaad Campbell
– Triceps
Reed Blankenship
– Thigh
Keilan Robinson
– Undisclosed
Brandon Johnson
– Undisclosed
Tristin McCollum
– Concussion
Lewis Cine
– Undisclosed
Darius Cooper
– Shoulder
Ben VanSumeren
– Knee
Tariq Castro-Fields
– Undisclosed
Charley Hughlett
– Abdomen
Patrick Johnson
– Gameday Inactive
Cameron Latu
– Stinger
Ogbo Okoronkwo
– Gameday Inactive
Cam Jurgens
– Knee
Zack Baun
– Knee
Jeremiah Trotter Jr.
– Ankle
Tyler Steen
– Oblique
Jalyx Hunt
– Hip
Lane Johnson
– Neck
Drew Kendall
– Gameday Inactive
Jordan Mailata
– Concussion
Landon Dickerson
– Back
Darian Kinnard
– Neck
Cameron Williams
– Gameday Inactive
Kendall Lamm
– Gameday Inactive
Kenyon Green
– Gameday Inactive
Trevor Keegan
– Gameday Inactive
Myles Hinton
– Undisclosed
Grant Calcaterra
– Illness
Ainias Smith
– Undisclosed
Harrison Bryant
– Shoulder
Dallas Goedert
– Knee
Johnny Wilson
– Knee/Ankle
Jordan Davis
– Shoulder
Byron Young
– Head
Ty Robinson
– Gameday Inactive
Moro Ojomo
– Shoulder
Jalen Carter
– Shoulder
Current Betting Odds
Spread: Eagles favored at 3
Total (Over/Under): 44.5
Moneyline Odds: Bills -167 , Eagles +141
Recent Matches
Bills
Eagles
Date
Vs
Result
Score
12/21/2025
Browns
win
20 :
23
12/14/2025
Patriots
win
31 :
35
12/07/2025
Bengals
win
39
: 34
11/30/2025
Steelers
win
7 :
26
11/20/2025
Texans
loss
23 :
19
11/16/2025
Buccaneers
win
44
: 32
11/09/2025
Dolphins
loss
30 :
13
11/02/2025
Chiefs
win
28
: 21
10/26/2025
Panthers
win
9 :
40
10/13/2025
Falcons
loss
24 :
14
W - 7
L - 3
Date
Vs
Result
Score
12/20/2025
Commanders
win
18 :
29
12/14/2025
Raiders
win
31
: 0
12/08/2025
Chargers
loss
22 :
19
11/28/2025
Bears
loss
15
: 24
11/23/2025
Cowboys
loss
24 :
21
11/16/2025
Lions
win
16
: 9
11/10/2025
Packers
win
7 :
10
10/26/2025
Giants
win
38
: 20
10/19/2025
Vikings
win
22 :
28
10/09/2025
Giants
loss
34 :
17
W - 6
L - 4
Who Wins: our Prediction
Based on statistical analysis, we see the Bills at a win probability of 40%, while the Eagles have a propability of 60% to win.
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