For Seahawks at Saints on Sunday, September 21, 2025, sportsbooks post Point Spread Saints with O/U 41.5 ML: Saints -375, Seahawks +300 appears on boards. Kickoff is 4:05 pm ET. Lines are live at books.
Money Line-350+310
Spread
-7.5
+100
7.0
-105
Over/Under
-110
Matchup Overview
Teams: Seahawks vs Saints
Date: Sunday, September 21, 2025
Time: 04:05 pm ET
Venue: Lumen Field
Where To Watch Seahawks vs Saints on Sunday
Watch the full match on CBS.
Injuries
Seahawks
Saints
DeMarcus Lawrence
– Quadricep
Marquez Valdes-Scantling
– Gameday Inactive
Drew Lock
– Personal
Nick Emmanwori
– Ankle
Jalen Milroe
– Gameday Inactive
Uchenna Nwosu
– Knee
Coby Bryant
– Personal
Kenneth Walker III
– Glute
Cooper Kupp
– Hamstring/Wrist
Jaxon Smith-Njigba
– Illness
Ernest Jones IV
– Shoulder
Sam Darnold
– Chest
Tory Horton
– Ankle
John Rhys Plumlee
– Undisclosed
Elijah Arroyo
– Groin
Jake Bobo
– Concussion
Julian Love
– Groin
Devon Witherspoon
– Knee
D'Anthony Bell
– Gameday Inactive
Shaquill Griffin
– Gameday Inactive
Kenny McIntosh
– Knee
Zach Charbonnet
– Foot
Riq Woolen
– Illness
Nehemiah Pritchett
– Hamstring
Josh Jobe
– Head
AJ Finley
– Knee
Jacardia Wright
– Undisclosed
Jerrick Reed II
– Gameday Inactive
George Holani
– Hamstring
Isas Waxter
– Knee
Brady Russell
– Wrist
Ty Okada
– Oblique
Robbie Ouzts
– Ankle
Drake Thomas
– Shoulder
Tyrice Knight
– Knee
Jared Ivey
– Gameday Inactive
Boye Mafe
– Toe
Connor O'Toole
– Gameday Inactive
Derick Hall
– Hip
Tyreke Smith
– Gameday Inactive
Jalen Sundell
– Ankle/Elbow
Christian Haynes
– Pectoral
Michael Jerrell
– Gameday Inactive
Charles Cross
– Finger
Abraham Lucas
– Elbow
Luke Felix-Fualalo
– Undisclosed
Josh Jones
– Ankle
Anthony Bradford
– Back
Grey Zabel
– Heel
Bryce Cabeldue
– Gameday Inactive
Mason Richman
– Gameday Inactive
Amari Kight
– Knee
Eric Saubert
– Calf
Cody White
– Shoulder
Dareke Young
– Hamstring
Tyrone Broden
– Undisclosed
AJ Barner
– Calf
Nick Kallerup
– Gameday Inactive
Jarran Reed
– Back
Quinton Bohanna
– Gameday Inactive
Mike Morris
– Concussion
Brandon Pili
– Knee
Johnathan Hankins
– Back
Rylie Mills
– Gameday Inactive
Leonard Williams
– Elbow/Shoulder
Shane Lemieux
– Undisclosed
Ugo Amadi
– Gameday Inactive
Alontae Taylor
– Groin
Spencer Rattler
– Right Finger
Kendre Miller
– Knee
Tyler Shough
– Hip
Taysom Hill
– Knee (ACL)
Cedrick Wilson Jr.
– Knee
Chris Olave
– Hip
Velus Jones Jr.
– Knee
Mason Tipton
– Ilness
Bub Means
– Ankle
Justin Reid
– Knee
Rashid Shaheed
– Leg
Rejzohn Wright
– Gameday Inactive
Cam Akers
– Gameday Inactive
Isaac Yiadom
– Hamstring
Julian Blackmon
– Labrum Tear
Devin Neal
– Gameday Inactive
Jordan Howden
– Oblique
Jonas Sanker
– Head
Rico Payton
– Hamstring
Alvin Kamara
– Ankle
J.T. Gray
– Hamstring
Zach Wood
– Hamstring
Khalen Saunders
– Gameday Inactive
Cesar Ruiz
– Ankle
D'Marco Jackson
– Hamstring
Jonah Williams
– Gameday Inactive
Demario Davis
– Calf
Jonathan Bullard
– Gameday Inactive
Nick Saldiveri
– Knee
Landon Young
– Ankle
Torricelli Simpkins III
– Gameday Inactive
Barry Wesley
– Gameday Inactive
Trevor Penning
– Toe
Taliese Fuaga
– Knee
Will Clapp
– Foot
Dillon Radunz
– Toe
Erik McCoy
– Biceps
Juwan Johnson
– Ankle
Foster Moreau
– Knee
Jack Stoll
– Toe
Chris Tyree
– Lower Body
Bryan Bresee
– Back
Vernon Broughton
– Gameday Inactive
Nathan Shepherd
– Ankle/Knee
Cameron Jordan
– Groin
John Ridgeway III
– Gameday Inactive
Khristian Boyd
– Hand
Chris Rumph II
– Wrist
Chase Young
– Calf
Current Betting Odds
Spread: Saints favored at 7
Total (Over/Under): 41.5
Moneyline Odds: Seahawks -375 , Saints +300
Recent Matches
Seahawks
Saints
Date
Vs
Result
Score
09/14/2025
Steelers
win
17 :
31
09/07/2025
49ers
loss
13
: 17
08/23/2025
Packers
loss
20 :
7
08/15/2025
Chiefs
win
33
: 16
08/07/2025
Raiders
draw
23
: 23
01/05/2025
Rams
win
25 :
30
12/26/2024
Bears
win
3 :
6
12/22/2024
Vikings
loss
24
: 27
12/15/2024
Packers
loss
13
: 30
12/08/2024
Cardinals
win
18 :
30
W - 5
D - 1
L - 4
Date
Vs
Result
Score
09/14/2025
49ers
loss
21
: 26
09/07/2025
Cardinals
loss
13
: 20
08/23/2025
Broncos
loss
19
: 28
08/17/2025
Jaguars
draw
17
: 17
08/10/2025
Chargers
loss
27 :
13
01/05/2025
Buccaneers
loss
27 :
19
12/29/2024
Raiders
loss
10
: 25
12/23/2024
Packers
loss
34 :
0
12/15/2024
Commanders
loss
19
: 20
12/08/2024
Giants
win
11 :
14
W - 1
D - 1
L - 8
Who Wins: our Prediction
Based on statistical analysis, we see the Seahawks at a win probability of 24%, while the Saints have a propability of 76% to win.
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