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    Saints vs Bills NFL Week 4 – Match Preview & Live Updates Sunday, September 28, 2025

    National Football League
    Bills
    Home
    28/09/2025
    1:00pm
    Saints
    Away
    Where To Watch Injuries Recent Matches Predicted Winner Futures Statistics

    Bills vs. Saints: Detailed Breakdown

    On Sunday, September 28, 2025, Bills face Saints. The Point Spread is Saints , while the Total is 48.5 M/L: Saints -1370, Bills +828 is available. Sportsbetting sites have full lines listed.

    Money Line -1099 Fanatics +900 FanDuel
    Spread -15.5 -105 DraftKings 14.5 -110 FanDuel
    Over/Under -105 DraftKings DraftKings

    Matchup Overview

    • Teams: Bills vs Saints
    • Date: Sunday, September 28, 2025
    • Time: 01:00 pm ET
    • Venue: Highmark Stadium

    Where To Watch Bills vs Saints on Sunday

    Watch the full match on CBS.

    Injuries

    Bills
    Saints
    Hayden Harris
    – Hamstring
    Keon Coleman
    – Groin
    Curtis Samuel
    – Elbow
    Tyler Bass
    – Left Hip/Groin
    Damar Hamlin
    – Pectoral
    James Cook
    – Hamstring
    Joshua Palmer
    – Ankle
    Taron Johnson
    – Groin
    Terrel Bernard
    – Hamstring
    Taylor Rapp
    – Nose
    Khalil Shakir
    – Ankle
    Mitchell Trubisky
    – Illness
    Jalen Virgil
    – Undisclosed
    Mike White
    – Gameday Inactive
    Josh Allen
    – Right Elbow
    Elijah Moore
    – Personal
    Darrynton Evans
    – Undisclosed
    Ray Davis
    – Illness
    Cole Bishop
    – Cramping
    Daequan Hardy
    – Undisclosed
    Ty Johnson
    – Ankle
    Tre'Davious White
    – Leg
    Darrick Forrest
    – Undisclosed
    Brandon Codrington
    – Knee
    Wande Owens
    – Undisclosed
    Maxwell Hairston
    – Knee
    Te'Cory Couch
    – Hamstring
    Jordan Hancock
    – Shoulder
    Cam Lewis
    – Shoulder
    Reggie Gilliam
    – Knee
    Dorian Williams
    – Knee
    Dorian Strong
    – Neck
    Shaq Thompson
    – Hamstring/Hand
    Ja'Marcus Ingram
    – Gameday Inactive
    Christian Benford
    – Groin
    Greg Rousseau
    – Knee
    Kendrick Green
    – Undisclosed
    Baylon Spector
    – Undisclosed
    Michael Hoecht
    – Suspension
    A.J. Epenesa
    – Pectoral
    Matt Milano
    – Pectoral
    Sedrick Van Pran-Granger
    – Undisclosed
    Connor McGovern
    – Hamstring
    Tylan Grable
    – Undisclosed
    Reid Ferguson
    – Neck
    Alec Anderson
    – Knee
    Marcus Harris
    – Knee
    Dion Dawkins
    – Thumb
    Chase Lundt
    – Gameday Inactive
    Spencer Brown
    – Undisclosed
    Tyrell Shavers
    – Knee
    Kaden Prather
    – Hamstring
    Jackson Hawes
    – Ankle
    Dalton Kincaid
    – Hamstring
    Dawson Knox
    – Hip
    DeWayne Carter
    – Achilles
    Ed Oliver
    – Bicep
    DaQuan Jones
    – Calf
    Landon Jackson
    – Gameday Inactive
    Deone Walker
    – Ilness
    Joey Bosa
    – Hamstring
    T.J. Sanders
    – Knee
    Larry Ogunjobi
    – Gameday Inactive
    Shane Lemieux
    – Undisclosed
    Ugo Amadi
    – Gameday Inactive
    Alontae Taylor
    – Groin
    Spencer Rattler
    – Right Finger
    Kendre Miller
    – Knee
    Tyler Shough
    – Hip
    Taysom Hill
    – Knee (ACL)
    Cedrick Wilson Jr.
    – Knee
    Chris Olave
    – Hip
    Velus Jones Jr.
    – Knee
    Mason Tipton
    – Undisclosed
    Bub Means
    – Ankle
    Justin Reid
    – Knee
    Rashid Shaheed
    – Leg
    Rejzohn Wright
    – Gameday Inactive
    Cam Akers
    – Gameday Inactive
    Isaac Yiadom
    – Hamstring
    Julian Blackmon
    – Labrum Tear
    Devin Neal
    – Gameday Inactive
    Jordan Howden
    – Oblique
    Jonas Sanker
    – Head
    Rico Payton
    – Leg
    Alvin Kamara
    – Ankle
    J.T. Gray
    – Hamstring
    Zach Wood
    – Hamstring
    Khalen Saunders
    – Gameday Inactive
    Cesar Ruiz
    – Ankle
    D'Marco Jackson
    – Hamstring
    Jonah Williams
    – Gameday Inactive
    Demario Davis
    – Calf
    Jonathan Bullard
    – Gameday Inactive
    Nick Saldiveri
    – Knee
    Landon Young
    – Ankle
    Torricelli Simpkins III
    – Gameday Inactive
    Barry Wesley
    – Gameday Inactive
    Trevor Penning
    – Toe
    Taliese Fuaga
    – Knee
    Will Clapp
    – Foot
    Dillon Radunz
    – Toe
    Erik McCoy
    – Biceps
    Juwan Johnson
    – Ankle
    Foster Moreau
    – Knee
    Jack Stoll
    – Toe
    Chris Tyree
    – Lower Body
    Bryan Bresee
    – ACL
    Vernon Broughton
    – Gameday Inactive
    Nathan Shepherd
    – Ankle/Knee
    Cameron Jordan
    – Groin
    John Ridgeway III
    – Gameday Inactive
    Khristian Boyd
    – Hand
    Chris Rumph II
    – Wrist
    Chase Young
    – Calf

    Current Betting Odds

    • Spread: Saints favored at 14.5
    • Total (Over/Under): 48.5
    • Moneyline Odds: Bills -1370 , Saints +828

    Recent Matches

    Bills
    Saints
    Date Vs Result Score
    09/18/2025 Dolphins win 31 : 21
    09/14/2025 Jets win 10 : 30
    09/07/2025 Ravens win 41 : 40
    08/23/2025 Buccaneers win 19 : 23
    08/17/2025 Bears loss 38 : 0
    08/09/2025 Giants loss 25 : 34
    01/26/2025 Chiefs loss 32 : 29
    01/19/2025 Ravens win 27 : 25
    01/12/2025 Broncos win 31 : 7
    01/05/2025 Patriots loss 23 : 16
    W - 6
    L - 4
    Date Vs Result Score
    09/21/2025 Seahawks loss 44 : 13
    09/14/2025 49ers loss 21 : 26
    09/07/2025 Cardinals loss 13 : 20
    08/23/2025 Broncos loss 19 : 28
    08/17/2025 Jaguars draw 17 : 17
    08/10/2025 Chargers loss 27 : 13
    01/05/2025 Buccaneers loss 27 : 19
    12/29/2024 Raiders loss 10 : 25
    12/23/2024 Packers loss 34 : 0
    12/15/2024 Commanders loss 19 : 20
    D - 1
    L - 9

    Who Wins: our Prediction

    Based on statistical analysis, we see the Bills at a win probability of 10%, while the Saints have a propability of 90% to win.

    Find the best Futures for Bills vs Saints

    Statistics

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    All Betting Tips
    Money Line -140 BetMGM +120 DraftKings
    Spread -2.5 -105 BetMGM 2.5 -105 DraftKings
    Over/Under -105 DraftKings DraftKings
    Money Line +210 DraftKings -240 Fanatics
    Spread 5.0 -105 BetMGM -5.0 -105 BetMGM
    Over/Under -108 DraftKings DraftKings
    Money Line +270 DraftKings -325 BetMGM
    Spread 6.5 -102 BetMGM -7.0 -110 FanDuel
    Over/Under -110 DraftKings DraftKings
    Money Line +108 FanDuel -120 DraftKings
    Spread 1.5 -108 FanDuel -1.5 -110 DraftKings
    Over/Under -104 FanDuel DraftKings
    Money Line +730 FanDuel -1000 BetMGM
    Spread 13.5 -102 DraftKings -13.5 -110 FanDuel
    Over/Under -108 DraftKings DraftKings
    Money Line +205 DraftKings -230 FanDuel
    Spread 4.5 -105 BetMGM -5.5 -102 FanDuel
    Over/Under -110 FanDuel DraftKings
    Money Line +190 FanDuel -225 DraftKings
    Spread 4.5 -108 DraftKings -4.5 -105 Fanatics
    Over/Under -108 DraftKings DraftKings
    Money Line -190 BetMGM +176 FanDuel
    Spread -3.5 -110 FanDuel 3.5 -105 Fanatics
    Over/Under -105 FanDuel DraftKings
    Money Line +300 DraftKings -350 BetMGM
    Spread 7.0 -105 BetMGM -7.5 -102 FanDuel
    Over/Under -110 BetMGM DraftKings
    Money Line -148 DraftKings +132 FanDuel
    Spread -3.0 -102 FanDuel 3.0 -115 DraftKings
    Over/Under -102 FanDuel DraftKings
    Money Line +130 FanDuel -145 BetMGM
    Spread 2.5 +100 DraftKings -2.5 -115 FanDuel
    Over/Under -110 FanDuel DraftKings
    Money Line -175 BetMGM +160 Fanatics
    Spread -3.5 -105 DraftKings 3.5 -110 BetMGM
    Over/Under -105 Fanatics DraftKings
    Money Line -629 Fanatics +490 FanDuel
    Spread -12.5 -106 FanDuel 12.5 -110 BetMGM
    Over/Under -102 DraftKings DraftKings
    Money Line +145 BetMGM -154 FanDuel
    Spread 3.0 -110 FanDuel -3.0 -108 DraftKings
    Over/Under -110 Fanatics DraftKings
    Money Line -426 Fanatics +360 FanDuel
    Spread -8.5 -110 FanDuel 8.5 -108 DraftKings
    Over/Under -106 FanDuel DraftKings
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