Rams host Eagles on Sunday, September 21, 2025. Books show Point Spread Rams and O/U 45.5 ML: Rams -199, Eagles +169 is also posted. Numbers reflect current listings from sportsbooks.
Money Line-190+172
Spread
-3.5
-110
3.5
-105
Over/Under
-105
Matchup Overview
Teams: Eagles vs Rams
Date: Sunday, September 21, 2025
Time: 01:00 pm ET
Venue: Lincoln Financial Field
Where To Watch Eagles vs Rams on Sunday
Watch the full match on FOX.
Injuries
Eagles
Rams
Joshua Uche
– Groin
Jahan Dotson
– Toe
Nolan Smith Jr.
– Triceps
DeVonta Smith
– Groin
Adoree' Jackson
– Groin
A.J. Brown
– Hamstring
Azeez Ojulari
– Gameday Inactive
Tanner McKee
– Thumb
Nakobe Dean
– Knee
Mac McWilliams
– Gameday Inactive
Andrew Mukuba
– Hamstring
Saquon Barkley
– Knee
Quinyon Mitchell
– Hamstring
Will Shipley
– Oblique
A.J. Dillon
– Gameday Inactive
Jihaad Campbell
– Triceps
Reed Blankenship
– Thigh
Keilan Robinson
– Undisclosed
Tristin McCollum
– Concussion
Lewis Cine
– Undisclosed
Darius Cooper
– Shoulder
Ben VanSumeren
– Knee
Tariq Castro-Fields
– Undisclosed
Charley Hughlett
– Abdomen
Patrick Johnson
– Gameday Inactive
Cameron Latu
– Stinger
Ogbo Okoronkwo
– Gameday Inactive
Cam Jurgens
– Knee
Zack Baun
– Knee
Jeremiah Trotter Jr.
– Ankle
Tyler Steen
– Oblique
Jalyx Hunt
– Hip
Lane Johnson
– Neck
Drew Kendall
– Gameday Inactive
Jordan Mailata
– Concussion
Landon Dickerson
– Back
Darian Kinnard
– Neck
Cameron Williams
– Gameday Inactive
Kendall Lamm
– Gameday Inactive
Kenyon Green
– Gameday Inactive
Trevor Keegan
– Gameday Inactive
Myles Hinton
– Undisclosed
Grant Calcaterra
– Illness
Harrison Bryant
– Shoulder
Dallas Goedert
– Knee
Johnny Wilson
– Knee/Ankle
Jordan Davis
– Shoulder
Byron Young
– Head
Ty Robinson
– Gameday Inactive
Moro Ojomo
– Shoulder
Jalen Carter
– Shoulder
Byron Young
– Knee
Derion Kendrick
– Gameday Inactive
Jaylen McCollough
– Illness
Ahkello Witherspoon
– Knee
Tutu Atwell
– Gameday Inactive
Drake Stoops
– Suspension
Jared Verse
– Knee
Jimmy Garoppolo
– Back
Puka Nacua
– Ankle
Stetson Bennett
– Gameday Inactive
Konata Mumpfield
– Calf
Joshua Karty
– Gameday Inactive
Davante Adams
– Hamstring
Terrance Ferguson
– Gameday Inactive
Xavier Smith
– Concussion
Charles Woods
– Concussion/Groin
Blake Corum
– Ankle
Kyren Williams
– Ankle
Darious Williams
– Personal
Emmanuel Forbes Jr.
– Shoulder
Kamren Kinchens
– Shoulder
A.J. Green
– Gameday Inactive
Josh Wallace
– Knee
Nick Hampton
– Illness
Cody Schrader
– Gameday Inactive
Tanner Ingle
– Gameday Inactive
Jarquez Hunter
– Gameday Inactive
Quentin Lake
– Illness
Shaun Jolly
– Undisclosed
Josaiah Stewart
– Concussion
Brennan Jackson
– Gameday Inactive
Alex Ward
– Gameday Inactive
Omar Speights
– Ankle
Beaux Limmer
– Gameday Inactive
Nate Landman
– Calf
Braden Fiske
– Oblique
Shaun Dolac
– Knee
Ty Hamilton
– Gameday Inactive
Willie Lampkin
– Knee
Justin Dedich
– Gameday Inactive
David Quessenberry
– Gameday Inactive
Kevin Dotson
– Ankle
KT Leveston
– Gameday Inactive
D.J. Humphries
– Gameday Inactive
Steve Avila
– Ankle
Alaric Jackson
– Illness
Rob Havenstein
– Ankle
Colby Parkinson
– Shoulder
Davis Allen
– Knee
Jordan Whittington
– Knee
Tyler Higbee
– Hip
Kobie Turner
– Back
Desjuan Johnson
– Gameday Inactive
Poona Ford
– Elbow
Keir Thomas
– Undisclosed
Current Betting Odds
Spread: Rams favored at 3.5
Total (Over/Under): 45.5
Moneyline Odds: Eagles -199 , Rams +169
Recent Matches
Eagles
Rams
Date
Vs
Result
Score
09/14/2025
Chiefs
win
17 :
20
09/04/2025
Cowboys
win
24
: 20
08/22/2025
Jets
win
17 :
19
08/16/2025
Browns
loss
13
: 22
08/07/2025
Bengals
win
34
: 27
02/09/2025
Chiefs
win
40
: 22
01/26/2025
Commanders
win
55
: 23
01/19/2025
Rams
win
28
: 22
01/12/2025
Packers
win
22
: 10
01/05/2025
Giants
win
20
: 13
W - 9
L - 1
Date
Vs
Result
Score
09/14/2025
Titans
win
19 :
33
09/07/2025
Texans
win
14
: 9
08/23/2025
Browns
loss
19 :
17
08/16/2025
Chargers
win
23
: 22
08/09/2025
Cowboys
win
31
: 21
01/19/2025
Eagles
loss
28 :
22
01/13/2025
Vikings
win
27
: 9
01/05/2025
Seahawks
loss
25
: 30
12/28/2024
Cardinals
win
13
: 9
12/22/2024
Jets
win
9 :
19
W - 7
L - 3
Who Wins: our Prediction
Based on statistical analysis, we see the Eagles at a win probability of 36%, while the Rams have a propability of 64% to win.
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