On Sunday, September 28, 2025, Giants face Chargers. The Point Spread is Giants , while the Total is 43 M/L: Chargers +229, Giants -284 is available. Sportsbetting sites have full lines listed.
Money Line+230-275
Spread
5.5
-105
-6.5
-102
Over/Under
-105
Matchup Overview
Teams: Giants vs Chargers
Date: Sunday, September 28, 2025
Time: 01:00 pm ET
Venue: MetLife Stadium
Where To Watch Giants vs Chargers on Sunday
The match will be broadcast by CBS.
Injuries
Giants
Chargers
Brian Burns
– Foot
Gunner Olszewski
– Back
Malik Nabers
– Toe
Deonte Banks
– Personal
Russell Wilson
– Ankle
Kayvon Thibodeaux
– Shoulder
Jaxson Dart
– Hamstring
Jevón Holland
– Calf
Beaux Collins
– Hamstring
Graham Gano
– Groin
Da'Quan Felton
– Undisclosed
Jamie Gillan
– Left Knee
Jalin Hyatt
– Gameday Inactive
Tommy DeVito
– Gameday Inactive
Wan'Dale Robinson
– Ankle
Darius Slayton
– Groin
Jameis Winston
– Gameday Inactive
Eric Gray
– Knee
Paulson Adebo
– Shoulder
Dru Phillips
– Hip
Dane Belton
– Shoulder
Dante Miller
– Gameday Inactive
Korie Black
– Biceps
Tyler Nubin
– Non Injury Related (Personal)
Cor'Dale Flott
– Concussion
Tyrone Tracy Jr.
– Calf
TJ Moore
– Leg
Nic Jones
– Hamstring
Art Green
– Hip
Rushawn Baker
– Knee
Tre Hawkins III
– Undisclosed
Micah McFadden
– Lower Leg
Demetrius Flannigan-Fowles
– Calf
Cam Skattebo
– Knee
Ty Summers
– Undisclosed
Jermaine Terry II
– Undisclosed
Chris Board
– Chest
Abdul Carter
– Hamstring
Victor Dimukeje
– Pectoral
Darius Muasau
– Concussion
James Hudson
– Gameday Inactive
Chauncey Golston
– Neck
Bobby Okereke
– Shoulder
John Michael Schmitz Jr.
– Ankle
Jermaine Eluemunor
– Shoulder/Back
Evan Neal
– Gameday Inactive
Greg Van Roten
– Shoulder
Joshua Ezeudu
– Undisclosed
Jon Runyan
– Back
Andrew Thomas
– Foot
Daniel Bellinger
– Neck
Theo Johnson
– Toe
Chris Manhertz
– Illness
Thomas Fidone II
– Gameday Inactive
Bryce Ford-Wheaton
– Knee
Elijah Garcia
– Gameday Inactive
Darius Alexander
– Gameday Inactive
Rakeem Nuñez-Roches
– Foot
Roy Robertson-Harris
– Knee
Dexter Lawrence II
– Elbow
D.J. Davidson
– Foot
Jordon Riley
– Achilles
Daiyan Henley
– Groin
Quentin Johnston
– Concussion
Elijah Molden
– Knee
Derwin James Jr.
– Glute
Denzel Perryman
– Ankle
Omarion Hampton
– Ankle
Tre Harris
– Jaw
Justin Herbert
– Hand
Derius Davis
– Knee
Ladd McConkey
– Biceps
Cam Hart
– Hip
Najee Harris
– Eye
Tony Jefferson
– Hamstring
Benjamin St-Juste
– Groin
Junior Colson
– Shoulder
Donte Jackson
– Ankle
RJ Mickens
– Gameday Inactive
Hassan Haskins
– Chest
Tarheeb Still
– Ankle
Kimani Vidal
– Neck
Trikweze Bridges
– Knee
Deane Leonard
– Undisclosed
Raheim Sanders
– Gameday Inactive
Jaylen Jones
– Undisclosed
Ja'Sir Taylor
– Illness
Jordan Oladokun
– Undisclosed
Emany Johnson
– Gameday Inactive
Dalevon Campbell
– Gameday Inactive
Eric Rogers
– Undisclosed
Kendall Williamson
– Achilles
Tucker Fisk
– Gameday Inactive
Troy Dye
– Thumb
Scott Matlock
– Ankle
McCallan Castles
– Undisclosed
Nikko Reed
– Gameday Inactive
Josh Harris
– Undisclosed
Bud Dupree
– Hamstring
Jordan Petaia
– Undisclosed
Caleb Murphy
– Gameday Inactive
Khalil Mack
– Elbow
Del'Shawn Phillips
– Undisclosed
Kyle Kennard
– Gameday Inactive
Kana'i Mauga
– Gameday Inactive
Jamaree Salyer
– Knee
Josh Fuga
– Undisclosed
Rashawn Slater
– Knee
Branson Taylor
– Gameday Inactive
M.Becton
– Illness
Bradley Bozeman
– Back
Joe Alt
– Ankle
Andre James
– Neck
Trey Pipkins III
– Knee
Tyler Conklin
– Gameday Inactive
Keandre Lambert-Smith
– Gameday Inactive
Oronde Gadsden
– Gameday Inactive
Dez Fitzpatrick
– Undisclosed
Jalen Reagor
– Undisclosed
Will Dissly
– Knee
Teair Tart
– Groin
Da'Shawn Hand
– Back
Justin Eboigbe
– Foot
Otito Ogbonnia
– Gameday Inactive
Naquan Jones
– Gameday Inactive
Jamaree Caldwell
– Illness
Current Betting Odds
Spread: Giants favored at 6
Total (Over/Under): 43
Moneyline Odds: Giants +229 , Chargers -284
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Giants
Chargers
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W - 4
L - 6
Date
Vs
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09/21/2025
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win
23
: 20
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win
9 :
20
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win
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: 21
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08/10/2025
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win
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: 13
07/31/2025
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win
7 :
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loss
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12
01/05/2025
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win
20 :
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12/28/2024
Patriots
win
7 :
40
W - 7
L - 3
Who Wins: our Prediction
Based on statistical analysis, we see the Giants at a win probability of 71%, while the Chargers have a propability of 29% to win.
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