On Sunday, December 21, 2025, Cowboys face Chargers. The Point Spread is Chargers , while the Total is 50.5 M/L: Chargers -121, Cowboys +102 is available. Sportsbetting sites have full lines listed.
Money Line-120+106
Spread
-1.5
-105
1.5
-110
Over/Under
-108
Matchup Overview
Teams: Cowboys vs Chargers
Date: Sunday, December 21, 2025
Time: 01:00 pm ET
Venue: AT&T Stadium
Where To Watch Cowboys vs Chargers on Sunday
Watch the full match on FOX.
Injuries
Cowboys
Chargers
Geron Christian
– Gameday Inactive
Matt Waletzko
– Ankle
DeMarvion Overshown
– Knee
Jalen Tolbert
– Gameday Inactive
Juanyeh Thomas
– Migraine
George Pickens
– Calf/Knee
Dak Prescott
– Hip
Bryan Anger
– Illness
Donovan Wilson
– Neck
Trevon Diggs
– Knee
KaVontae Turpin
– Shoulder
Joe Milton III
– Personal
Micah Parsons
– Back
Dante Fowler Jr.
– Shoulder
Markquese Bell
– Lower Body
Damone Clark
– Gameday Inactive
Ryan Flournoy
– Knee
Caelen Carson
– Knee
Buddy Johnson
– Gameday Inactive
DaRon Bland
– Foot
Miles Sanders
– Shoulder
Shavon Revel Jr.
– Undisclosed
Malik Hooker
– Toe
R.Rochell
– Ankle
Josh Butler
– Knee
J.Williams
– Neck
Jaydon Blue
– Ankle
Bruce Harmon
– Knee
Christian Matthew
– Undisclosed
Phil Mafah
– Shoulder
Alijah Clark
– Ribs
Hunter Luepke
– Hip
Kemon Hall
– Suspension
Darius Harris
– Undisclosed
Zion Childress
– Gameday Inactive
John Stephens Jr.
– Undisclosed
Shemar James
– Gameday Inactive
Tyler Booker
– Ankle
James Houston
– Knee
Sam Williams
– Shoulder
Cooper Beebe
– Ankle
Jack Sanborn
– Concussion
Mazi Smith
– Gameday Inactive
Kenneth Murray Jr.
– Knee
Tyler Guyton
– Knee
Dakoda Shepley
– Undisclosed
Rob Jones
– Neck
T.J. Bass
– Thumb
Ajani Cornelius
– Gameday Inactive
Nate Thomas
– Shoulder
Tyler Smith
– Knee
Hakeem Adeniji
– Gameday Inactive
Asim Richards
– Ankle
Terence Steele
– Migraine
P.Campbell
– Undisclosed
Jonathan Mingo
– Knee
Jalen Brooks
– Undisclosed
Luke Schoonmaker
– Concussion
Jake Ferguson
– Calf
CeeDee Lamb
– Ankle
Brevyn Spann-Ford
– Ankle
Solomon Thomas
– Calf
Tyrus Wheat
– Gameday Inactive
Jay Toia
– Gameday Inactive
Marshawn Kneeland
– Ankle
Osa Odighizuwa
– Elbow
Payton Turner
– Ribs
Perrion Winfrey
– Back
Daiyan Henley
– Groin
Quentin Johnston
– Concussion
Elijah Molden
– Knee
Derwin James Jr.
– Glute
Denzel Perryman
– Ankle
Omarion Hampton
– Ankle
Tre Harris
– Jaw
Justin Herbert
– Hand
Derius Davis
– Knee
Ladd McConkey
– Biceps
Cam Hart
– Hip
Najee Harris
– Eye
Tony Jefferson
– Hamstring
Benjamin St-Juste
– Groin
Junior Colson
– Shoulder
Donte Jackson
– Ankle
RJ Mickens
– Gameday Inactive
Hassan Haskins
– Chest
Tarheeb Still
– Ankle
Kimani Vidal
– Neck
Trikweze Bridges
– Knee
Deane Leonard
– Undisclosed
Raheim Sanders
– Gameday Inactive
Jaylen Jones
– Undisclosed
Ja'Sir Taylor
– Illness
Jordan Oladokun
– Undisclosed
Emany Johnson
– Gameday Inactive
Dalevon Campbell
– Gameday Inactive
Eric Rogers
– Undisclosed
Kendall Williamson
– Achilles
Tucker Fisk
– Gameday Inactive
Troy Dye
– Thumb
Scott Matlock
– Ankle
McCallan Castles
– Undisclosed
Nikko Reed
– Gameday Inactive
Josh Harris
– Undisclosed
Bud Dupree
– Hamstring
Jordan Petaia
– Undisclosed
Caleb Murphy
– Gameday Inactive
Khalil Mack
– Elbow
Del'Shawn Phillips
– Undisclosed
Kyle Kennard
– Gameday Inactive
Kana'i Mauga
– Gameday Inactive
Jamaree Salyer
– Knee
Josh Fuga
– Undisclosed
Rashawn Slater
– Knee
Branson Taylor
– Gameday Inactive
M.Becton
– Illness
Bradley Bozeman
– Back
Joe Alt
– Ankle
Andre James
– Neck
Trey Pipkins III
– Knee
Tyler Conklin
– Gameday Inactive
Keandre Lambert-Smith
– Gameday Inactive
Oronde Gadsden
– Gameday Inactive
Dez Fitzpatrick
– Undisclosed
Jalen Reagor
– Undisclosed
Will Dissly
– Knee
Teair Tart
– Groin
Da'Shawn Hand
– Back
Justin Eboigbe
– Foot
Otito Ogbonnia
– Gameday Inactive
Naquan Jones
– Gameday Inactive
Jamaree Caldwell
– Illness
Current Betting Odds
Spread: Chargers favored at 1.5
Total (Over/Under): 50.5
Moneyline Odds: Cowboys -121 , Chargers +102
Recent Matches
Cowboys
Chargers
Date
Vs
Result
Score
12/14/2025
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loss
26
: 34
12/04/2025
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loss
44 :
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11/27/2025
Chiefs
win
31
: 28
11/23/2025
Eagles
win
24
: 21
11/17/2025
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win
16 :
33
11/03/2025
Cardinals
loss
17
: 27
10/26/2025
Broncos
loss
44 :
24
10/19/2025
Commanders
win
44
: 22
10/12/2025
Panthers
loss
30 :
27
10/05/2025
Jets
win
22 :
37
W - 5
L - 5
Date
Vs
Result
Score
12/14/2025
Chiefs
win
13 :
16
12/08/2025
Eagles
win
22
: 19
11/30/2025
Raiders
win
31
: 14
11/16/2025
Jaguars
loss
35 :
6
11/09/2025
Steelers
win
25
: 10
11/02/2025
Titans
win
20 :
27
10/23/2025
Vikings
win
37
: 10
10/19/2025
Colts
loss
24
: 38
10/12/2025
Dolphins
win
27 :
29
10/05/2025
Commanders
loss
10
: 27
W - 7
L - 3
Who Wins: our Prediction
Based on statistical analysis, we see the Cowboys at a win probability of 47%, while the Chargers have a propability of 53% to win.
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