Giants vs Chiefs is scheduled for Sunday, September 21, 2025 at 8:20 pm ET. Point Spread: Giants ; O/U: 44.5 ML: Chiefs +248, Giants -305. Lines are available across major sportsbetting sites.
Money Line+260-300
Spread
5.5
-102
-6.0
-110
Over/Under
-110
Matchup Overview
Teams: Giants vs Chiefs
Date: Sunday, September 21, 2025
Time: 08:20 pm ET
Venue: MetLife Stadium
Where To Watch Giants vs Chiefs on Sunday
The match will be broadcast by NBC.
Injuries
Giants
Chiefs
Brian Burns
– Foot
Gunner Olszewski
– Achilles
Malik Nabers
– Toe
Deonte Banks
– Personal
Russell Wilson
– Ankle
Kayvon Thibodeaux
– Shoulder
Jaxson Dart
– Hamstring
Jevón Holland
– Calf
Beaux Collins
– Hamstring
Graham Gano
– Groin
Da'Quan Felton
– Undisclosed
Jamie Gillan
– Left Knee
Jalin Hyatt
– Gameday Inactive
Tommy DeVito
– Gameday Inactive
Wan'Dale Robinson
– Ankle
Darius Slayton
– Groin
Jameis Winston
– Gameday Inactive
Eric Gray
– Knee
Paulson Adebo
– Shoulder
Dru Phillips
– Hip
Dane Belton
– Shoulder
Dante Miller
– Gameday Inactive
Korie Black
– Biceps
Tyler Nubin
– Non Injury Related (Personal)
Cor'Dale Flott
– Concussion
Tyrone Tracy Jr.
– Calf
TJ Moore
– Leg
Nic Jones
– Hamstring
Art Green
– Hip
Rushawn Baker
– Knee
Tre Hawkins III
– Undisclosed
Micah McFadden
– Lower Leg
Demetrius Flannigan-Fowles
– Calf
Cam Skattebo
– Knee
Ty Summers
– Undisclosed
Jermaine Terry II
– Undisclosed
Chris Board
– Chest
Abdul Carter
– Hamstring
Victor Dimukeje
– Pectoral
Darius Muasau
– Concussion
James Hudson
– Gameday Inactive
Chauncey Golston
– Neck
Bobby Okereke
– Shoulder
John Michael Schmitz Jr.
– Ankle
Jermaine Eluemunor
– Shoulder/Back
Evan Neal
– Gameday Inactive
Greg Van Roten
– Shoulder
Joshua Ezeudu
– Undisclosed
Jon Runyan
– Back
Andrew Thomas
– Foot
Daniel Bellinger
– Neck
Theo Johnson
– Toe
Chris Manhertz
– Illness
Thomas Fidone II
– Gameday Inactive
Bryce Ford-Wheaton
– Knee
Elijah Garcia
– Gameday Inactive
Darius Alexander
– Gameday Inactive
Rakeem Nuñez-Roches
– Foot
Roy Robertson-Harris
– Knee
Dexter Lawrence II
– Elbow
D.J. Davidson
– Foot
Jordon Riley
– Achilles
Keaontay Ingram
– Undisclosed
Darius Rush
– Undisclosed
BJ Thompson
– Illness
Eric Scott Jr.
– Knee
Xavier Worthy
– Shoulder/Knee
Joshua Williams
– Gameday Inactive
Tyquan Thornton
– Head
Rashee Rice
– Suspended
Marquise Brown
– Ankle
Bryan Cook
– Ankle
Kristian Fulton
– Undisclosed
JuJu Smith-Schuster
– Knee
Isiah Pacheco
– Knee
Jalen Royals
– Knee
Jared Wiley
– Knee
Nazeeh Johnson
– Suspension
Patrick Mahomes
– Right Wrist
Gardner Minshew
– Knee
Jaden Hicks
– Pectoral
Trent McDuffie
– Knee
Drue Tranquill
– Back
Skyy Moore
– Ankle
Elijah Mitchell
– Gameday Inactive
Deon Bush
– Achilles
Chamarri Conner
– Wrist
Kareem Hunt
– Calf
Chris Roland-Wallace
– Hand
Brashard Smith
– Illness
Jeffrey Bassa
– Knee
Nick Bolton
– Biceps
Mike Edwards
– Shoulder
Jaylen Watson
– Back
Melvin Smith Jr.
– Gameday Inactive
James Winchester
– Hamstring
Jack Cochrane
– Knee
Cam Jones
– Hip
Ajani Carter
– Hamstring
Brandon George
– Undisclosed
Mike Danna
– Quadriceps
Creed Humphrey
– Rib
Leo Chenal
– Knee
Omarr Norman-Lott
– Ankle
George Karlaftis
– Thumb
Hunter Nourzad
– Gameday Inactive
C.J. Hanson
– Gameday Inactive
Wanya Morris
– Gameday Inactive
Trey Smith
– Knee/Illness
Josh Simmons
– Illness
Jawaan Taylor
– Knee
Ethan Driskell
– Appendix
Kingsley Suamataia
– Concussion
Jaylon Moore
– Illness
Esa Pole
– Ankle
Nikko Remigio
– Thumb
Noah Gray
– Concussion/Shoulder
Jake Briningstool
– Hamstring
Jason Brownlee
– Gameday Inactive
Charles Omenihu
– Ankle
Felix Anudike-Uzomah
– Hamstring
Malik Herring
– Gameday Inactive
Chris Jones
– Personal
Ashton Gillotte
– Elbow
Janarius Robinson
– Foot
Jerry Tillery
– Elbow
Current Betting Odds
Spread: Giants favored at 6
Total (Over/Under): 44.5
Moneyline Odds: Giants +248 , Chiefs -305
Recent Matches
Giants
Chiefs
Date
Vs
Result
Score
09/14/2025
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loss
40 :
37
09/07/2025
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loss
21 :
6
08/21/2025
Patriots
win
42
: 10
08/16/2025
Jets
win
31
: 12
08/09/2025
Bills
win
25 :
34
01/05/2025
Eagles
loss
20 :
13
12/29/2024
Colts
win
45
: 33
12/22/2024
Falcons
loss
34 :
7
12/15/2024
Ravens
loss
14
: 35
12/08/2024
Saints
loss
11
: 14
W - 4
L - 6
Date
Vs
Result
Score
09/14/2025
Eagles
loss
17
: 20
09/05/2025
Chargers
loss
27 :
21
08/22/2025
Bears
loss
27
: 29
08/15/2025
Seahawks
loss
33 :
16
08/09/2025
Cardinals
loss
20 :
17
02/09/2025
Eagles
loss
40 :
22
01/26/2025
Bills
win
32
: 29
01/18/2025
Texans
win
23
: 14
01/05/2025
Broncos
loss
38 :
0
12/25/2024
Steelers
win
10 :
29
W - 3
L - 7
Who Wins: our Prediction
Based on statistical analysis, we see the Giants at a win probability of 72%, while the Chiefs have a propability of 28% to win.
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