The slate moves into Friday with Chargers at Chiefs. Current point spread: Chargers ; O/U: 47.5 ML: Chiefs +149, Chargers -175. Books list full pricing ahead of kickoff at 8:00 pm ET.
Money Line+145-165
Spread
3.0
+100
-3.0
-105
Over/Under
-105
Matchup Overview
Teams: Chargers vs Chiefs
Date: Friday, September 05, 2025
Time: 08:00 pm ET
Venue: Arena Corinthians
Where To Watch Chargers vs Chiefs on Friday
Watch the full match on YT.
Injuries
Chargers
Chiefs
Daiyan Henley
– Groin
Quentin Johnston
– Concussion
Elijah Molden
– Knee
Derwin James Jr.
– Glute
Denzel Perryman
– Ankle
Omarion Hampton
– Ankle
Tre Harris
– Jaw
Justin Herbert
– Hand
Derius Davis
– Knee
Ladd McConkey
– Biceps
Cam Hart
– Hip
Najee Harris
– Eye
Tony Jefferson
– Hamstring
Benjamin St-Juste
– Groin
Junior Colson
– Shoulder
Donte Jackson
– Ankle
RJ Mickens
– Gameday Inactive
Hassan Haskins
– Chest
Tarheeb Still
– Ankle
Kimani Vidal
– Neck
Trikweze Bridges
– Knee
Deane Leonard
– Undisclosed
Raheim Sanders
– Gameday Inactive
Jaylen Jones
– Undisclosed
Ja'Sir Taylor
– Illness
Jordan Oladokun
– Undisclosed
Emany Johnson
– Gameday Inactive
Dalevon Campbell
– Gameday Inactive
Eric Rogers
– Undisclosed
Kendall Williamson
– Achilles
Tucker Fisk
– Gameday Inactive
Troy Dye
– Thumb
Scott Matlock
– Ankle
McCallan Castles
– Undisclosed
Nikko Reed
– Gameday Inactive
Josh Harris
– Undisclosed
Bud Dupree
– Hamstring
Jordan Petaia
– Undisclosed
Caleb Murphy
– Gameday Inactive
Khalil Mack
– Elbow
Del'Shawn Phillips
– Undisclosed
Kyle Kennard
– Gameday Inactive
Kana'i Mauga
– Gameday Inactive
Jamaree Salyer
– Knee
Josh Fuga
– Undisclosed
Rashawn Slater
– Knee
Branson Taylor
– Gameday Inactive
M.Becton
– Illness
Bradley Bozeman
– Back
Joe Alt
– Ankle
Andre James
– Neck
Trey Pipkins III
– Knee
Tyler Conklin
– Gameday Inactive
Keandre Lambert-Smith
– Gameday Inactive
Oronde Gadsden
– Gameday Inactive
Dez Fitzpatrick
– Undisclosed
Jalen Reagor
– Undisclosed
Will Dissly
– Knee
Teair Tart
– Groin
Da'Shawn Hand
– Back
Justin Eboigbe
– Foot
Otito Ogbonnia
– Gameday Inactive
Naquan Jones
– Gameday Inactive
Jamaree Caldwell
– Illness
Keaontay Ingram
– Undisclosed
Darius Rush
– Undisclosed
BJ Thompson
– Illness
Eric Scott Jr.
– Knee
Xavier Worthy
– Shoulder/Knee
Joshua Williams
– Gameday Inactive
Tyquan Thornton
– Head
Rashee Rice
– Suspended
Marquise Brown
– Ankle
Bryan Cook
– Ankle
Kristian Fulton
– Undisclosed
JuJu Smith-Schuster
– Knee
Isiah Pacheco
– Knee
Jalen Royals
– Knee
Jared Wiley
– Knee
Nazeeh Johnson
– Shoulder
Patrick Mahomes
– Right Wrist
Gardner Minshew
– Knee
Jaden Hicks
– Pectoral
Trent McDuffie
– Knee
Drue Tranquill
– Back
Skyy Moore
– Ankle
Elijah Mitchell
– Gameday Inactive
Deon Bush
– Achilles
Chamarri Conner
– Wrist
Kareem Hunt
– Calf
Chris Roland-Wallace
– Hand
Brashard Smith
– Illness
Jeffrey Bassa
– Knee
Nick Bolton
– Biceps
Mike Edwards
– Shoulder
Jaylen Watson
– Back
Melvin Smith Jr.
– Gameday Inactive
James Winchester
– Hamstring
Jack Cochrane
– Knee
Cam Jones
– Hip
Ajani Carter
– Hamstring
Brandon George
– Undisclosed
Mike Danna
– Quadriceps
Creed Humphrey
– Rib
Leo Chenal
– Knee
Omarr Norman-Lott
– Ankle
George Karlaftis
– Thumb
Hunter Nourzad
– Gameday Inactive
C.J. Hanson
– Gameday Inactive
Wanya Morris
– Gameday Inactive
Trey Smith
– Knee/Illness
Josh Simmons
– Illness
Jawaan Taylor
– Knee
Ethan Driskell
– Appendix
Kingsley Suamataia
– Concussion
Jaylon Moore
– Illness
Esa Pole
– Ankle
Nikko Remigio
– Thumb
Noah Gray
– Concussion/Shoulder
Jake Briningstool
– Hamstring
Jason Brownlee
– Gameday Inactive
Charles Omenihu
– Ankle
Felix Anudike-Uzomah
– Hamstring
Malik Herring
– Gameday Inactive
Chris Jones
– Personal
Ashton Gillotte
– Elbow
Janarius Robinson
– Foot
Jerry Tillery
– Elbow
Current Betting Odds
Spread: Chargers favored at 3
Total (Over/Under): 47.5
Moneyline Odds: Chargers +149 , Chiefs -175
Recent Matches
Chargers
Chiefs
Date
Vs
Result
Score
08/23/2025
49ers
loss
30 :
23
08/16/2025
Rams
loss
23 :
22
08/10/2025
Saints
win
27
: 13
07/31/2025
Lions
win
7 :
34
01/11/2025
Texans
loss
32 :
12
01/05/2025
Raiders
win
20 :
34
12/28/2024
Patriots
win
7 :
40
12/19/2024
Broncos
win
34
: 27
12/15/2024
Buccaneers
loss
17
: 40
12/08/2024
Chiefs
loss
19 :
17
W - 5
L - 5
Date
Vs
Result
Score
08/22/2025
Bears
loss
27
: 29
08/15/2025
Seahawks
loss
33 :
16
08/09/2025
Cardinals
loss
20 :
17
02/09/2025
Eagles
loss
40 :
22
01/26/2025
Bills
win
32
: 29
01/18/2025
Texans
win
23
: 14
01/05/2025
Broncos
loss
38 :
0
12/25/2024
Steelers
win
10 :
29
12/21/2024
Texans
win
27
: 19
12/15/2024
Browns
win
7 :
21
W - 5
L - 5
Who Wins: our Prediction
Based on statistical analysis, we see the Chargers at a win probability of 61%, while the Chiefs have a propability of 39% to win.
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