Chargers vs Chiefs NFL Week 1 – Match Preview & Live Updates Friday, September 05, 2025

National Football League
Chargers
Home
05/09/2025
8:00pm
Chiefs
Away

Chargers vs. Chiefs: Detailed Breakdown

The slate moves into Friday with Chargers at Chiefs. Current point spread: Chargers ; O/U: 47.5 ML: Chiefs +149, Chargers -175. Books list full pricing ahead of kickoff at 8:00 pm ET.

Money Line +145 DraftKings -165 BetMGM
Spread 3.0 +100 DraftKings -3.0 -105 BetMGM
Over/Under -105 FanDuel DraftKings

Matchup Overview

  • Teams: Chargers vs Chiefs
  • Date: Friday, September 05, 2025
  • Time: 08:00 pm ET
  • Venue: Arena Corinthians

Where To Watch Chargers vs Chiefs on Friday

Watch the full match on YT.

Injuries

Chargers
Chiefs
Daiyan Henley
– Groin
Quentin Johnston
– Concussion
Elijah Molden
– Knee
Derwin James Jr.
– Glute
Denzel Perryman
– Ankle
Omarion Hampton
– Ankle
Tre Harris
– Jaw
Justin Herbert
– Hand
Derius Davis
– Knee
Ladd McConkey
– Biceps
Cam Hart
– Hip
Najee Harris
– Eye
Tony Jefferson
– Hamstring
Benjamin St-Juste
– Groin
Junior Colson
– Shoulder
Donte Jackson
– Ankle
RJ Mickens
– Gameday Inactive
Hassan Haskins
– Chest
Tarheeb Still
– Ankle
Kimani Vidal
– Neck
Trikweze Bridges
– Knee
Deane Leonard
– Undisclosed
Raheim Sanders
– Gameday Inactive
Jaylen Jones
– Undisclosed
Ja'Sir Taylor
– Illness
Jordan Oladokun
– Undisclosed
Emany Johnson
– Gameday Inactive
Dalevon Campbell
– Gameday Inactive
Eric Rogers
– Undisclosed
Kendall Williamson
– Achilles
Tucker Fisk
– Gameday Inactive
Troy Dye
– Thumb
Scott Matlock
– Ankle
McCallan Castles
– Undisclosed
Nikko Reed
– Gameday Inactive
Josh Harris
– Undisclosed
Bud Dupree
– Hamstring
Jordan Petaia
– Undisclosed
Caleb Murphy
– Gameday Inactive
Khalil Mack
– Elbow
Del'Shawn Phillips
– Undisclosed
Kyle Kennard
– Gameday Inactive
Kana'i Mauga
– Gameday Inactive
Jamaree Salyer
– Knee
Josh Fuga
– Undisclosed
Rashawn Slater
– Knee
Branson Taylor
– Gameday Inactive
M.Becton
– Illness
Bradley Bozeman
– Back
Joe Alt
– Ankle
Andre James
– Neck
Trey Pipkins III
– Knee
Tyler Conklin
– Gameday Inactive
Keandre Lambert-Smith
– Gameday Inactive
Oronde Gadsden
– Gameday Inactive
Dez Fitzpatrick
– Undisclosed
Jalen Reagor
– Undisclosed
Will Dissly
– Knee
Teair Tart
– Groin
Da'Shawn Hand
– Back
Justin Eboigbe
– Foot
Otito Ogbonnia
– Gameday Inactive
Naquan Jones
– Gameday Inactive
Jamaree Caldwell
– Illness
Keaontay Ingram
– Undisclosed
Darius Rush
– Undisclosed
BJ Thompson
– Illness
Eric Scott Jr.
– Knee
Xavier Worthy
– Shoulder/Knee
Joshua Williams
– Gameday Inactive
Tyquan Thornton
– Head
Rashee Rice
– Suspended
Marquise Brown
– Ankle
Bryan Cook
– Ankle
Kristian Fulton
– Undisclosed
JuJu Smith-Schuster
– Knee
Isiah Pacheco
– Knee
Jalen Royals
– Knee
Jared Wiley
– Knee
Nazeeh Johnson
– Shoulder
Patrick Mahomes
– Right Wrist
Gardner Minshew
– Knee
Jaden Hicks
– Pectoral
Trent McDuffie
– Knee
Drue Tranquill
– Back
Skyy Moore
– Ankle
Elijah Mitchell
– Gameday Inactive
Deon Bush
– Achilles
Chamarri Conner
– Wrist
Kareem Hunt
– Calf
Chris Roland-Wallace
– Hand
Brashard Smith
– Illness
Jeffrey Bassa
– Knee
Nick Bolton
– Biceps
Mike Edwards
– Shoulder
Jaylen Watson
– Back
Melvin Smith Jr.
– Gameday Inactive
James Winchester
– Hamstring
Jack Cochrane
– Knee
Cam Jones
– Hip
Ajani Carter
– Hamstring
Brandon George
– Undisclosed
Mike Danna
– Quadriceps
Creed Humphrey
– Rib
Leo Chenal
– Knee
Omarr Norman-Lott
– Ankle
George Karlaftis
– Thumb
Hunter Nourzad
– Gameday Inactive
C.J. Hanson
– Gameday Inactive
Wanya Morris
– Gameday Inactive
Trey Smith
– Knee/Illness
Josh Simmons
– Illness
Jawaan Taylor
– Knee
Ethan Driskell
– Appendix
Kingsley Suamataia
– Concussion
Jaylon Moore
– Illness
Esa Pole
– Ankle
Nikko Remigio
– Thumb
Noah Gray
– Concussion/Shoulder
Jake Briningstool
– Hamstring
Jason Brownlee
– Gameday Inactive
Charles Omenihu
– Ankle
Felix Anudike-Uzomah
– Hamstring
Malik Herring
– Gameday Inactive
Chris Jones
– Personal
Ashton Gillotte
– Elbow
Janarius Robinson
– Foot
Jerry Tillery
– Elbow

Current Betting Odds

  • Spread: Chargers favored at 3
  • Total (Over/Under): 47.5
  • Moneyline Odds: Chargers +149 , Chiefs -175

Recent Matches

Chargers
Chiefs
Date Vs Result Score
08/23/2025 49ers loss 30 : 23
08/16/2025 Rams loss 23 : 22
08/10/2025 Saints win 27 : 13
07/31/2025 Lions win 7 : 34
01/11/2025 Texans loss 32 : 12
01/05/2025 Raiders win 20 : 34
12/28/2024 Patriots win 7 : 40
12/19/2024 Broncos win 34 : 27
12/15/2024 Buccaneers loss 17 : 40
12/08/2024 Chiefs loss 19 : 17
W - 5
L - 5
Date Vs Result Score
08/22/2025 Bears loss 27 : 29
08/15/2025 Seahawks loss 33 : 16
08/09/2025 Cardinals loss 20 : 17
02/09/2025 Eagles loss 40 : 22
01/26/2025 Bills win 32 : 29
01/18/2025 Texans win 23 : 14
01/05/2025 Broncos loss 38 : 0
12/25/2024 Steelers win 10 : 29
12/21/2024 Texans win 27 : 19
12/15/2024 Browns win 7 : 21
W - 5
L - 5

Who Wins: our Prediction

Based on statistical analysis, we see the Chargers at a win probability of 61%, while the Chiefs have a propability of 39% to win.

Find the best Futures for Chargers vs Chiefs

Statistics

Want Even More Picks To Profit From?
Money Line -116 FanDuel +100 BetMGM
Spread -1.5 -105 DraftKings 1.0 -110 BetMGM
Over/Under -102 FanDuel DraftKings
Money Line +176 FanDuel -200 BetMGM
Spread 3.5 -102 FanDuel -3.5 -105 BetMGM
Over/Under -108 DraftKings DraftKings
Money Line +130 DraftKings -152 FanDuel
Spread 3.0 -115 BetMGM -3.0 -102 DraftKings
Over/Under -108 DraftKings DraftKings
Money Line +455 DraftKings -592 FanDuel
Spread 10.0 -105 BetMGM -10.5 -104 FanDuel
Over/Under -110 BetMGM DraftKings
Money Line -120 BetMGM +106 FanDuel
Spread -1.5 -105 BetMGM 1.5 -110 FanDuel
Over/Under -108 FanDuel DraftKings
Money Line -180 DraftKings +154 BetMGM
Spread -3.5 +100 DraftKings 3.5 -115 BetMGM
Over/Under -110 FanDuel DraftKings
Money Line +135 BetMGM -150 Fanatics
Spread 2.5 -102 FanDuel -3.0 -102 BetMGM
Over/Under -108 FanDuel DraftKings
Money Line -1299 Fanatics +950 DraftKings
Spread -14.5 +100 FanDuel 14.0 -105 Fanatics
Over/Under -105 Fanatics DraftKings
Money Line -375 BetMGM +320 DraftKings
Spread -7.5 -105 BetMGM 7.5 -105 BetMGM
Over/Under -105 DraftKings DraftKings
Money Line -190 BetMGM +164 DraftKings
Spread -3.5 -105 DraftKings 3.5 -110 Fanatics
Over/Under -105 FanDuel DraftKings
Money Line +187.5 FanDuel -218 DraftKings
Spread 4.5 -114 FanDuel -4.5 -105 DraftKings
Over/Under -102 DraftKings DraftKings
Money Line +370 DraftKings -450 Fanatics
Spread 8.5 -105 FanDuel -8.5 -108 DraftKings
Over/Under -108 FanDuel DraftKings
Money Line +300 BetMGM -350 FanDuel
Spread 7.0 -102 FanDuel -7.5 +100 DraftKings
Over/Under -108 DraftKings DraftKings
Money Line +810 FanDuel -1000 BetMGM
Spread 13.5 -106 FanDuel -13.5 -105 DraftKings
Over/Under -105 DraftKings DraftKings
Money Line -115 Fanatics +102 FanDuel
Spread -1.5 -105 DraftKings 1.5 -110 FanDuel
Over/Under -110 FanDuel DraftKings
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