Chiefs– is set for Sunday, November 02, 2025 at 4:25 pm ET. Sportsbooks list Point Spread Bills and Total 53 M/L: Chiefs +112, Bills -132 is available. Lines are posted across books.
Money Line+122-130
Spread
2.0
-105
-2.5
-105
Over/Under
-105
Matchup Overview
Teams: Bills vs Chiefs
Date: Sunday, November 02, 2025
Time: 04:25 pm ET
Venue: Highmark Stadium
Where To Watch Bills vs Chiefs on Sunday
Watch the full match on CBS.
Injuries
Bills
Chiefs
Hayden Harris
– Hamstring
Keon Coleman
– Groin
Curtis Samuel
– Elbow
Tyler Bass
– Left Hip/Groin
Damar Hamlin
– Pectoral
James Cook
– Hamstring
Joshua Palmer
– Ankle
Taron Johnson
– Groin
Terrel Bernard
– Hamstring
Taylor Rapp
– Nose
Khalil Shakir
– Ankle
Mitchell Trubisky
– Illness
Jalen Virgil
– Undisclosed
Mike White
– Gameday Inactive
Josh Allen
– Right Elbow
Elijah Moore
– Personal
Darrynton Evans
– Undisclosed
Ray Davis
– Illness
Cole Bishop
– Cramping
Daequan Hardy
– Undisclosed
Ty Johnson
– Ankle
Tre'Davious White
– Leg
Darrick Forrest
– Undisclosed
Brandon Codrington
– Knee
Wande Owens
– Undisclosed
Maxwell Hairston
– Knee
Te'Cory Couch
– Hamstring
Jordan Hancock
– Shoulder
Cam Lewis
– Shoulder
Reggie Gilliam
– Knee
Dorian Williams
– Knee
Dorian Strong
– Neck
Shaq Thompson
– Hamstring/Hand
Ja'Marcus Ingram
– Gameday Inactive
Christian Benford
– Groin
Greg Rousseau
– Knee
Kendrick Green
– Undisclosed
Baylon Spector
– Undisclosed
Michael Hoecht
– Suspension
A.J. Epenesa
– Pectoral
Matt Milano
– Pectoral
Sedrick Van Pran-Granger
– Undisclosed
Connor McGovern
– Hamstring
Tylan Grable
– Undisclosed
Reid Ferguson
– Neck
Alec Anderson
– Knee
Marcus Harris
– Knee
Dion Dawkins
– Thumb
Chase Lundt
– Gameday Inactive
Spencer Brown
– Undisclosed
Tyrell Shavers
– Knee
Kaden Prather
– Hamstring
Jackson Hawes
– Ankle
Dalton Kincaid
– Hamstring
Dawson Knox
– Hip
DeWayne Carter
– Achilles
Ed Oliver
– Bicep
DaQuan Jones
– Calf
Landon Jackson
– Gameday Inactive
Deone Walker
– Ilness
Joey Bosa
– Hamstring
T.J. Sanders
– Knee
Larry Ogunjobi
– Gameday Inactive
Keaontay Ingram
– Undisclosed
Darius Rush
– Undisclosed
BJ Thompson
– Illness
Eric Scott Jr.
– Knee
Xavier Worthy
– Shoulder/Knee
Joshua Williams
– Gameday Inactive
Tyquan Thornton
– Head
Rashee Rice
– Suspended
Marquise Brown
– Ankle
Bryan Cook
– Ankle
Kristian Fulton
– Undisclosed
JuJu Smith-Schuster
– Knee
Isiah Pacheco
– Knee
Jalen Royals
– Knee
Jared Wiley
– Knee
Nazeeh Johnson
– Suspension
Patrick Mahomes
– Right Wrist
Gardner Minshew
– Knee
Jaden Hicks
– Pectoral
Trent McDuffie
– Knee
Drue Tranquill
– Back
Skyy Moore
– Ankle
Elijah Mitchell
– Gameday Inactive
Deon Bush
– Achilles
Chamarri Conner
– Wrist
Kareem Hunt
– Calf
Chris Roland-Wallace
– Hand
Brashard Smith
– Illness
Jeffrey Bassa
– Knee
Nick Bolton
– Biceps
Mike Edwards
– Shoulder
Jaylen Watson
– Back
Melvin Smith Jr.
– Gameday Inactive
James Winchester
– Hamstring
Jack Cochrane
– Knee
Cam Jones
– Hip
Ajani Carter
– Hamstring
Brandon George
– Undisclosed
Mike Danna
– Quadriceps
Creed Humphrey
– Rib
Leo Chenal
– Knee
Omarr Norman-Lott
– Ankle
George Karlaftis
– Thumb
Hunter Nourzad
– Gameday Inactive
C.J. Hanson
– Gameday Inactive
Wanya Morris
– Gameday Inactive
Trey Smith
– Knee/Illness
Josh Simmons
– Illness
Jawaan Taylor
– Knee
Ethan Driskell
– Appendix
Kingsley Suamataia
– Concussion
Jaylon Moore
– Illness
Esa Pole
– Ankle
Nikko Remigio
– Thumb
Noah Gray
– Concussion/Shoulder
Jake Briningstool
– Hamstring
Jason Brownlee
– Gameday Inactive
Charles Omenihu
– Ankle
Felix Anudike-Uzomah
– Hamstring
Malik Herring
– Gameday Inactive
Chris Jones
– Personal
Ashton Gillotte
– Elbow
Janarius Robinson
– Foot
Jerry Tillery
– Elbow
Current Betting Odds
Spread: Bills favored at 2
Total (Over/Under): 53
Moneyline Odds: Bills +112 , Chiefs -132
Recent Matches
Bills
Chiefs
Date
Vs
Result
Score
10/26/2025
Panthers
win
9 :
40
10/13/2025
Falcons
loss
24 :
14
10/05/2025
Patriots
loss
20
: 23
09/28/2025
Saints
win
31
: 19
09/18/2025
Dolphins
win
31
: 21
09/14/2025
Jets
win
10 :
30
09/07/2025
Ravens
win
41
: 40
08/23/2025
Buccaneers
win
19 :
23
08/17/2025
Bears
loss
38 :
0
08/09/2025
Giants
loss
25
: 34
W - 6
L - 4
Date
Vs
Result
Score
10/27/2025
Commanders
win
28
: 7
10/19/2025
Raiders
win
31
: 0
10/12/2025
Lions
win
30
: 17
10/06/2025
Jaguars
loss
31 :
28
09/28/2025
Ravens
win
37
: 20
09/21/2025
Giants
win
9 :
22
09/14/2025
Eagles
loss
17
: 20
09/05/2025
Chargers
loss
27 :
21
08/22/2025
Bears
loss
27
: 29
08/15/2025
Seahawks
loss
33 :
16
W - 5
L - 5
Who Wins: our Prediction
Based on statistical analysis, we see the Bills at a win probability of 55%, while the Chiefs have a propability of 45% to win.
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