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    Jaguars vs 49ers NFL Week 4 – Match Preview & Live Updates Sunday, September 28, 2025

    National Football League
    49ers
    Home
    28/09/2025
    4:05pm
    Jaguars
    Away
    Where To Watch Injuries Recent Matches Predicted Winner Futures Statistics

    49ers vs. Jaguars: Detailed Breakdown

    For 49ers at Jaguars on Sunday, September 28, 2025, sportsbooks post Point Spread Jaguars with O/U 45.5 ML: Jaguars -173, 49ers +146 appears on boards. Kickoff is 4:05 pm ET. Lines are live at books.

    Money Line -168 FanDuel +150 DraftKings
    Spread -3.5 +104 FanDuel 3.0 -105 Fanatics
    Over/Under -110 BetMGM DraftKings

    Matchup Overview

    • Teams: 49ers vs Jaguars
    • Date: Sunday, September 28, 2025
    • Time: 04:05 pm ET
    • Venue: Levi's Stadium

    Where To Watch 49ers vs Jaguars on Sunday

    Watch the full match on FOX.

    Injuries

    49ers
    Jaguars
    Ameer Abdullah
    – Ribs
    Isaiah Prince
    – Knee
    Tre Tomlinson
    – Undisclosed
    Carter Bradley
    – Undisclosed
    Renardo Green
    – Neck
    Ricky Pearsall
    – Knee
    Deommodore Lenoir
    – Hip
    Kurtis Rourke
    – Knee
    Demarcus Robinson
    – Suspended
    Malik Mustapha
    – Knee
    Thomas Morstead
    – Back
    Mac Jones
    – Knee
    Brandon Aiyuk
    – Personal
    Brock Purdy
    – Left Shoulder/Toe
    Tanner Mordecai
    – Undisclosed
    Jauan Jennings
    – Calf
    Jordan Watkins
    – Gameday Inactive
    Jacob Cowing
    – Hamstring
    Upton Stout
    – Calf
    Tre Brown
    – Heel
    Christian McCaffrey
    – Calf
    Richie Grant
    – Knee
    Jason Pinnock
    – Heel
    Chase Lucas
    – Undisclosed
    Ji'Ayir Brown
    – Hamstring
    Darrell Luter Jr.
    – Achilles
    Jordan James
    – Gameday Inactive
    Eli Apple
    – Gameday Inactive
    Isaac Guerendo
    – Gameday Inactive
    Patrick Taylor Jr.
    – Shoulder
    Siran Neal
    – Head
    Dallis Flowers
    – Undisclosed
    Marques Sigle
    – Gameday Inactive
    Kyle Juszczyk
    – Concussion
    Nick Martin
    – Gameday Inactive
    Chazz Surratt
    – Ankle
    B.Huff
    – Ankle
    Tatum Bethune
    – Thigh
    Corey Kiner
    – Undisclosed
    Jakob Robinson
    – Forearm
    Robert Beal Jr.
    – Gameday Inactive
    Dee Winters
    – Knee
    Fred Warner
    – Ankle
    Drew Moss
    – Gameday Inactive
    Sebastian Valdez
    – Gameday Inactive
    Tarron Jackson
    – Neck
    Luke Gifford
    – Knee
    Curtis Robinson
    – Knee
    Matt Hennessy
    – Neck
    Austen Pleasants
    – Gameday Inactive
    Jake Brendel
    – Hamstring
    A.Dillard
    – Undisclosed
    Isaac Alarcon
    – Suspension
    Colton McKivitz
    – Calf
    Trent Williams
    – Knee
    Spencer Burford
    – Knee
    Connor Colby
    – Gameday Inactive
    Dominick Puni
    – Knee
    Ben Bartch
    – Undisclosed
    Trent Taylor
    – Undisclosed
    George Kittle
    – Achilles
    Mason Pline
    – Undisclosed
    Kevin Givens
    – Pectoral
    Sam Okuayinonu
    – Shoulder
    Jordan Elliott
    – Ankle
    Kalia Davis
    – Groin
    Yetur Gross-Matos
    – Undisclosed
    Alfred Collins
    – Shoulder
    Jonathan Garvin
    – Undisclosed
    Nick Bosa
    – Neck
    Mykel Williams
    – Knee
    CJ West
    – Knee
    Levi Wallace
    – Undisclosed
    Devin Lloyd
    – Calf
    Travis Etienne Jr.
    – Shoulder
    Jourdan Lewis
    – Neck
    Tyson Campbell
    – Quad
    Tank Bigsby
    – Illness
    Dyami Brown
    – Shoulder
    Darnell Savage
    – Gameday Inactive
    Brian Thomas Jr.
    – Wrist
    Logan Cooke
    – Personal
    Eli Pancol
    – Undisclosed
    Parker Washington
    – Hamstring
    Travis Hunter
    – Knee
    Trevor Lawrence
    – Ankle
    John Wolford
    – Gameday Inactive
    Daniel Thomas
    – Hand
    Christian Braswell
    – Hamstring
    Jarrian Jones
    – Back
    Foyesade Oluokun
    – Illness
    Antonio Johnson
    – Elbow
    Caleb Ransaw
    – Foot
    Eric Murray
    – Neck
    Montaric Brown
    – Ankle
    Bhayshul Tuten
    – Shoulder
    Zechariah McPhearson
    – Undisclosed
    Josh Hines-Allen
    – Illness/Shoulder
    Andrew Wingard
    – Concussion
    Travon Walker
    – Wrist
    Quintin Morris
    – Groin
    Ross Matiscik
    – Back
    Chad Muma
    – Gameday Inactive
    Ventrell Miller
    – Back
    DaVon Hamilton
    – Back
    Jalen McLeod
    – Lower Body
    Jack Kiser
    – Shoulder
    Chuma Edoga
    – Knee
    Yasir Abdullah
    – Hamstring
    Dennis Gardeck
    – Knee
    Wyatt Milum
    – Knee
    Patrick Mekari
    – Elbow
    Cole Van Lanen
    – Shoulder
    Walker Little
    – Concussion
    Robert Hainsey
    – Hamstring
    F.Johnson
    – Ankle
    Cooper Hodges
    – Knee
    Ezra Cleveland
    – Ankle
    Anton Harrison
    – Elbow
    Joshua Cephus
    – Undisclosed
    Hunter Long
    – Gameday Inactive
    Brenton Strange
    – Hip
    Johnny Mundt
    – Gameday Inactive
    Emmanuel Ogbah
    – Gameday Inactive
    Arik Armstead
    – Back
    Danny Striggow
    – Gameday Inactive
    Tyler Lacy
    – Gameday Inactive
    Maason Smith
    – Undisclosed
    B.J. Green II
    – Gameday Inactive
    Ethan Downs
    – Knee
    Jordan Jefferson
    – Gameday Inactive

    Current Betting Odds

    • Spread: Jaguars favored at 3.5
    • Total (Over/Under): 45.5
    • Moneyline Odds: 49ers -173 , Jaguars +146

    Recent Matches

    49ers
    Jaguars
    Date Vs Result Score
    09/21/2025 Cardinals win 16 : 15
    09/14/2025 Saints win 21 : 26
    09/07/2025 Seahawks win 13 : 17
    08/23/2025 Chargers win 30 : 23
    08/16/2025 Raiders win 19 : 22
    08/09/2025 Broncos loss 9 : 30
    01/05/2025 Cardinals loss 47 : 24
    12/30/2024 Lions loss 34 : 40
    12/22/2024 Dolphins loss 29 : 17
    12/12/2024 Rams loss 6 : 12
    W - 5
    L - 5
    Date Vs Result Score
    09/21/2025 Texans win 17 : 10
    09/14/2025 Bengals loss 31 : 27
    09/07/2025 Panthers win 26 : 10
    08/23/2025 Dolphins loss 14 : 6
    08/17/2025 Saints draw 17 : 17
    08/09/2025 Steelers loss 25 : 31
    01/05/2025 Colts loss 26 : 23
    12/29/2024 Titans win 20 : 13
    12/22/2024 Raiders loss 19 : 14
    12/15/2024 Jets loss 25 : 32
    W - 3
    D - 1
    L - 6

    Who Wins: our Prediction

    Based on statistical analysis, we see the 49ers at a win probability of 39%, while the Jaguars have a propability of 61% to win.

    Find the best Futures for 49ers vs Jaguars

    Statistics

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