Titans vs Colts is scheduled for Sunday, September 21, 2025 at 1:00 pm ET. Point Spread: Titans ; O/U: 42.5 ML: Colts +210, Titans -253. Lines are available across major sportsbetting sites.
Money Line+225-250
Spread
5.5
-108
-6.0
-108
Over/Under
-108
Matchup Overview
Teams: Titans vs Colts
Date: Sunday, September 21, 2025
Time: 01:00 pm ET
Venue: Nissan Stadium
Where To Watch Titans vs Colts on Sunday
The match will be broadcast by CBS.
Injuries
Titans
Colts
Treylon Burks
– Collarbone
Calvin Ridley
– General Soreness
Cam Ward
– Ankle/Calf
Tyjae Spears
– Ankle
Johnny Hekker
– Illness
Tyler Lockett
– Knee
Elic Ayomanor
– Hamstring
Joey Slye
– Right Calf
Oluwafemi Oladejo
– Calf
Will Levis
– Shoulder
Van Jefferson
– Ankle
Mason Kinsey
– Gameday Inactive
James Proche II
– Gameday Inactive
Chimere Dike
– Chest
Tony Pollard
– Neck
Roger McCreary
– Hip
Kevin Winston Jr.
– Hamstring
Julius Wood
– Suspension
Xavier Woods
– Ankle
Marcus Harris
– Calf
Kalel Mullings
– Ankle
Jarvis Brownlee Jr.
– Ankle
Kendell Brooks
– Concussion
Julius Chestnut
– Back
Amani Hooker
– Ribs
L'Jarius Sneed
– Knee/Quad
Darrell Baker Jr.
– Head
Mike Brown
– Knee
Dre'Mont Jones
– Knee
Arden Key
– Pectoral
C.Barton
– Personal
Cedric Gray
– Concussion
James Williams
– Gameday Inactive
Jihad Ward
– Personal
JC Latham
– Hip
Anfernee Orji
– ACL
John Ojukwu
– Gameday Inactive
Corey Levin
– Neck
Jackson Slater
– Gameday Inactive
Chandler Brewer
– Undisclosed
Sebastian Joseph-Day
– Calf
Kevin Zeitler
– Hamstring
Cam Horsley
– Gameday Inactive
Blake Hance
– Shoulder
Dan Moore Jr.
– Ankle
Brandon Crenshaw-Dickson
– Gameday Inactive
Lloyd Cushenberry III
– Achilles
Bryce Oliver
– Knee
Josh Whyle
– Concussion
Matt Landers
– Undisclosed
Gunnar Helm
– Toe
Chig Okonkwo
– Foot
Xavier Restrepo
– Ankle
Thomas Odukoya
– Gameday Inactive
T'Vondre Sweat
– Mouth
James Lynch
– Shoulder
Jeffery Simmons
– Ankle
Ali Gaye
– Knee
Josh Downs
– Hamstring
D.J. Montgomery
– Undisclosed
Spencer Shrader
– Knee
Anthony Richardson Sr.
– Eye
Anthony Gould
– Illness
Charvarius Ward
– Concussion
Rigoberto Sanchez
– Personal
Adonai Mitchell
– Gameday Inactive
Michael Pittman Jr.
– Glute
Alec Pierce
– Knee
Riley Leonard
– Gameday Inactive
Ashton Dulin
– Concussion
Daniel Jones
– Fibula
Nick Cross
– Hip
DJ Giddens
– Gameday Inactive
Kenny Moore II
– Calf
Khalil Herbert
– Gameday Inactive
Justin Walley
– Knee
JuJu Brents
– Gameday Inactive
Hunter Wohler
– Foot
Tyler Goodson
– Elbow
Samuel Womack III
– Gameday Inactive
Johnathan Edwards
– Gameday Inactive
Salvon Ahmed
– Ankle
Daniel Scott
– Knee
Chris Lammons
– Foot
Jaylon Jones
– Hamstring
Zaire Franklin
– Ankle
Liam Anderson
– Undisclosed
Joe Bachie
– Quadricep
Maddux Trujillo
– Undisclosed
Kwity Paye
– Groin
Samson Ebukam
– Back
Jacob Phillips
– Bicep
Quenton Nelson
– Wrist
Jaylon Carlies
– Ankle
Austin Ajiake
– Throat
Cameron McGrone
– Achilles
Tanor Bortolini
– Concussion
Danny Pinter
– Rib
Luke Tenuta
– Gameday Inactive
Dalton Tucker
– Shoulder
Matt Goncalves
– Personal
Braden Smith
– Groin
Blake Freeland
– Leg
Jack Wilson
– Undisclosed
Bernhard Raimann
– Illness
Jelani Woods
– Gameday Inactive
Tyler Warren
– Toe
Drew Ogletree
– Neck
Will Mallory
– Gameday Inactive
Grover Stewart
– Biceps
JT Tuimoloau
– Gameday Inactive
Neville Gallimore
– Knee
Tyquan Lewis
– Oblique
Laiatu Latu
– Hamstring
Eric Johnson II
– Gameday Inactive
DeForest Buckner
– Back
Current Betting Odds
Spread: Titans favored at 6
Total (Over/Under): 42.5
Moneyline Odds: Titans +210 , Colts -253
Recent Matches
Titans
Colts
Date
Vs
Result
Score
09/14/2025
Rams
loss
19
: 33
09/07/2025
Broncos
loss
20 :
12
08/22/2025
Vikings
win
23
: 13
08/15/2025
Falcons
win
20 :
23
08/09/2025
Buccaneers
loss
29 :
7
01/05/2025
Texans
loss
14
: 23
12/29/2024
Jaguars
loss
20 :
13
12/22/2024
Colts
loss
38 :
30
12/15/2024
Bengals
loss
27
: 37
12/08/2024
Jaguars
loss
6
: 10
W - 2
L - 8
Date
Vs
Result
Score
09/14/2025
Broncos
win
29
: 28
09/07/2025
Dolphins
win
33
: 8
08/23/2025
Bengals
win
14 :
41
08/16/2025
Packers
loss
19
: 23
08/07/2025
Ravens
loss
24 :
16
01/05/2025
Jaguars
win
26
: 23
12/29/2024
Giants
loss
45 :
33
12/22/2024
Titans
win
38
: 30
12/15/2024
Broncos
loss
31 :
13
12/01/2024
Patriots
win
24 :
25
W - 6
L - 4
Who Wins: our Prediction
Based on statistical analysis, we see the Titans at a win probability of 69%, while the Colts have a propability of 31% to win.
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