Titans vs Colts NFL Week 3 – Match Preview & Live Updates Sunday, September 21, 2025

National Football League
Titans
Home
21/09/2025
1:00pm
Colts
Away

Titans vs. Colts: Detailed Breakdown

Titans vs Colts is scheduled for Sunday, September 21, 2025 at 1:00 pm ET. Point Spread: Titans ; O/U: 42.5 ML: Colts +210, Titans -253. Lines are available across major sportsbetting sites.

Money Line +225 BetMGM -250 DraftKings
Spread 5.5 -108 FanDuel -6.0 -108 DraftKings
Over/Under -108 FanDuel DraftKings

Matchup Overview

  • Teams: Titans vs Colts
  • Date: Sunday, September 21, 2025
  • Time: 01:00 pm ET
  • Venue: Nissan Stadium

Where To Watch Titans vs Colts on Sunday

The match will be broadcast by CBS.

Injuries

Titans
Colts
Treylon Burks
– Collarbone
Calvin Ridley
– General Soreness
Cam Ward
– Ankle/Calf
Tyjae Spears
– Ankle
Johnny Hekker
– Illness
Tyler Lockett
– Knee
Elic Ayomanor
– Hamstring
Joey Slye
– Right Calf
Oluwafemi Oladejo
– Calf
Will Levis
– Shoulder
Van Jefferson
– Ankle
Mason Kinsey
– Gameday Inactive
James Proche II
– Gameday Inactive
Chimere Dike
– Chest
Tony Pollard
– Neck
Roger McCreary
– Hip
Kevin Winston Jr.
– Hamstring
Julius Wood
– Suspension
Xavier Woods
– Ankle
Marcus Harris
– Calf
Kalel Mullings
– Ankle
Jarvis Brownlee Jr.
– Ankle
Kendell Brooks
– Concussion
Julius Chestnut
– Back
Amani Hooker
– Ribs
L'Jarius Sneed
– Knee/Quad
Darrell Baker Jr.
– Head
Mike Brown
– Knee
Dre'Mont Jones
– Knee
Arden Key
– Pectoral
C.Barton
– Personal
Cedric Gray
– Concussion
James Williams
– Gameday Inactive
Jihad Ward
– Personal
JC Latham
– Hip
Anfernee Orji
– ACL
John Ojukwu
– Gameday Inactive
Corey Levin
– Neck
Jackson Slater
– Gameday Inactive
Chandler Brewer
– Undisclosed
Sebastian Joseph-Day
– Calf
Kevin Zeitler
– Hamstring
Cam Horsley
– Gameday Inactive
Blake Hance
– Shoulder
Dan Moore Jr.
– Ankle
Brandon Crenshaw-Dickson
– Gameday Inactive
Lloyd Cushenberry III
– Achilles
Bryce Oliver
– Knee
Josh Whyle
– Concussion
Matt Landers
– Undisclosed
Gunnar Helm
– Toe
Chig Okonkwo
– Foot
Xavier Restrepo
– Ankle
Thomas Odukoya
– Gameday Inactive
T'Vondre Sweat
– Mouth
James Lynch
– Shoulder
Jeffery Simmons
– Ankle
Ali Gaye
– Knee
Josh Downs
– Hamstring
D.J. Montgomery
– Undisclosed
Spencer Shrader
– Knee
Anthony Richardson Sr.
– Eye
Anthony Gould
– Illness
Charvarius Ward
– Concussion
Rigoberto Sanchez
– Personal
Adonai Mitchell
– Gameday Inactive
Michael Pittman Jr.
– Glute
Alec Pierce
– Knee
Riley Leonard
– Gameday Inactive
Ashton Dulin
– Concussion
Daniel Jones
– Fibula
Nick Cross
– Hip
DJ Giddens
– Gameday Inactive
Kenny Moore II
– Calf
Khalil Herbert
– Gameday Inactive
Justin Walley
– Knee
JuJu Brents
– Gameday Inactive
Hunter Wohler
– Foot
Tyler Goodson
– Elbow
Samuel Womack III
– Gameday Inactive
Johnathan Edwards
– Gameday Inactive
Salvon Ahmed
– Ankle
Daniel Scott
– Knee
Chris Lammons
– Foot
Jaylon Jones
– Hamstring
Zaire Franklin
– Ankle
Liam Anderson
– Undisclosed
Joe Bachie
– Quadricep
Maddux Trujillo
– Undisclosed
Kwity Paye
– Groin
Samson Ebukam
– Back
Jacob Phillips
– Bicep
Quenton Nelson
– Wrist
Jaylon Carlies
– Ankle
Austin Ajiake
– Throat
Cameron McGrone
– Achilles
Tanor Bortolini
– Concussion
Danny Pinter
– Rib
Luke Tenuta
– Gameday Inactive
Dalton Tucker
– Shoulder
Matt Goncalves
– Personal
Braden Smith
– Groin
Blake Freeland
– Leg
Jack Wilson
– Undisclosed
Bernhard Raimann
– Illness
Jelani Woods
– Gameday Inactive
Tyler Warren
– Toe
Drew Ogletree
– Neck
Will Mallory
– Gameday Inactive
Grover Stewart
– Biceps
JT Tuimoloau
– Gameday Inactive
Neville Gallimore
– Knee
Tyquan Lewis
– Oblique
Laiatu Latu
– Hamstring
Eric Johnson II
– Gameday Inactive
DeForest Buckner
– Back

Current Betting Odds

  • Spread: Titans favored at 6
  • Total (Over/Under): 42.5
  • Moneyline Odds: Titans +210 , Colts -253

Recent Matches

Titans
Colts
Date Vs Result Score
09/14/2025 Rams loss 19 : 33
09/07/2025 Broncos loss 20 : 12
08/22/2025 Vikings win 23 : 13
08/15/2025 Falcons win 20 : 23
08/09/2025 Buccaneers loss 29 : 7
01/05/2025 Texans loss 14 : 23
12/29/2024 Jaguars loss 20 : 13
12/22/2024 Colts loss 38 : 30
12/15/2024 Bengals loss 27 : 37
12/08/2024 Jaguars loss 6 : 10
W - 2
L - 8
Date Vs Result Score
09/14/2025 Broncos win 29 : 28
09/07/2025 Dolphins win 33 : 8
08/23/2025 Bengals win 14 : 41
08/16/2025 Packers loss 19 : 23
08/07/2025 Ravens loss 24 : 16
01/05/2025 Jaguars win 26 : 23
12/29/2024 Giants loss 45 : 33
12/22/2024 Titans win 38 : 30
12/15/2024 Broncos loss 31 : 13
12/01/2024 Patriots win 24 : 25
W - 6
L - 4

Who Wins: our Prediction

Based on statistical analysis, we see the Titans at a win probability of 69%, while the Colts have a propability of 31% to win.

Find the best Futures for Titans vs Colts

Statistics

Want Even More Picks To Profit From?
Money Line -116 FanDuel +100 BetMGM
Spread -1.5 -105 DraftKings 1.0 -110 BetMGM
Over/Under -102 FanDuel DraftKings
Money Line +176 FanDuel -200 BetMGM
Spread 3.5 -102 FanDuel -3.5 -105 BetMGM
Over/Under -108 DraftKings DraftKings
Money Line +130 DraftKings -152 FanDuel
Spread 3.0 -115 BetMGM -3.0 -102 DraftKings
Over/Under -108 DraftKings DraftKings
Money Line +455 DraftKings -592 FanDuel
Spread 10.0 -105 BetMGM -10.5 -104 FanDuel
Over/Under -110 BetMGM DraftKings
Money Line -120 BetMGM +106 FanDuel
Spread -1.5 -105 BetMGM 1.5 -110 FanDuel
Over/Under -108 FanDuel DraftKings
Money Line -180 DraftKings +154 BetMGM
Spread -3.5 +100 DraftKings 3.5 -115 BetMGM
Over/Under -110 FanDuel DraftKings
Money Line +135 BetMGM -150 Fanatics
Spread 2.5 -102 FanDuel -3.0 -102 BetMGM
Over/Under -108 FanDuel DraftKings
Money Line -1299 Fanatics +950 DraftKings
Spread -14.5 +100 FanDuel 14.0 -105 Fanatics
Over/Under -105 Fanatics DraftKings
Money Line -375 BetMGM +320 DraftKings
Spread -7.5 -105 BetMGM 7.5 -105 BetMGM
Over/Under -105 DraftKings DraftKings
Money Line -190 BetMGM +164 DraftKings
Spread -3.5 -105 DraftKings 3.5 -110 Fanatics
Over/Under -105 FanDuel DraftKings
Money Line +187.5 FanDuel -218 DraftKings
Spread 4.5 -114 FanDuel -4.5 -105 DraftKings
Over/Under -102 DraftKings DraftKings
Money Line +370 DraftKings -450 Fanatics
Spread 8.5 -105 FanDuel -8.5 -108 DraftKings
Over/Under -108 FanDuel DraftKings
Money Line +300 BetMGM -350 FanDuel
Spread 7.0 -102 FanDuel -7.5 +100 DraftKings
Over/Under -108 DraftKings DraftKings
Money Line +810 FanDuel -1000 BetMGM
Spread 13.5 -106 FanDuel -13.5 -105 DraftKings
Over/Under -105 DraftKings DraftKings
Money Line -115 Fanatics +102 FanDuel
Spread -1.5 -105 DraftKings 1.5 -110 FanDuel
Over/Under -110 FanDuel DraftKings
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