Colts vs Rams NFL Week 4 – Match Preview & Live Updates Sunday, September 28, 2025

National Football League
Rams
Home
28/09/2025
4:05pm
Colts
Away

Rams vs. Colts: Detailed Breakdown

Rams travel to Colts for Sunday’s game. Books post Point Spread Colts and Total 49.5 M/L: Colts -189, Rams +159 is on offer. Kick time is 4:05 pm ET.

Money Line -184 FanDuel +160 Fanatics
Spread -3.5 -105 FanDuel 3.5 -105 DraftKings
Over/Under -110 BetMGM DraftKings

Matchup Overview

  • Teams: Rams vs Colts
  • Date: Sunday, September 28, 2025
  • Time: 04:05 pm ET
  • Venue: SoFi Stadium

Where To Watch Rams vs Colts on Sunday

The match will be broadcast by FOX.

Injuries

Rams
Colts
Byron Young
– Knee
Derion Kendrick
– Gameday Inactive
Jaylen McCollough
– Illness
Ahkello Witherspoon
– Knee
Tutu Atwell
– Gameday Inactive
Drake Stoops
– Suspension
Jared Verse
– Knee
Jimmy Garoppolo
– Back
Puka Nacua
– Ankle
Stetson Bennett
– Gameday Inactive
Konata Mumpfield
– Calf
Joshua Karty
– Gameday Inactive
Davante Adams
– Hamstring
Terrance Ferguson
– Gameday Inactive
Xavier Smith
– Concussion
Charles Woods
– Concussion/Groin
Blake Corum
– Ankle
Kyren Williams
– Ankle
Darious Williams
– Personal
Emmanuel Forbes Jr.
– Shoulder
Kamren Kinchens
– Shoulder
A.J. Green
– Gameday Inactive
Josh Wallace
– Knee
Nick Hampton
– Illness
Cody Schrader
– Gameday Inactive
Tanner Ingle
– Gameday Inactive
Jarquez Hunter
– Gameday Inactive
Quentin Lake
– Illness
Shaun Jolly
– Undisclosed
Josaiah Stewart
– Concussion
Brennan Jackson
– Gameday Inactive
Alex Ward
– Gameday Inactive
Omar Speights
– Ankle
Beaux Limmer
– Gameday Inactive
Nate Landman
– Calf
Braden Fiske
– Oblique
Shaun Dolac
– Knee
Ty Hamilton
– Gameday Inactive
Willie Lampkin
– Knee
Justin Dedich
– Gameday Inactive
David Quessenberry
– Gameday Inactive
Kevin Dotson
– Ankle
KT Leveston
– Gameday Inactive
D.J. Humphries
– Gameday Inactive
Steve Avila
– Ankle
Alaric Jackson
– Illness
Rob Havenstein
– Ankle
Colby Parkinson
– Shoulder
Davis Allen
– Knee
Jordan Whittington
– Knee
Tyler Higbee
– Hip
Kobie Turner
– Back
Desjuan Johnson
– Gameday Inactive
Poona Ford
– Elbow
Keir Thomas
– Undisclosed
Josh Downs
– Hamstring
D.J. Montgomery
– Undisclosed
Spencer Shrader
– Knee
Anthony Richardson Sr.
– Eye
Anthony Gould
– Illness
Charvarius Ward
– Concussion
Rigoberto Sanchez
– Personal
Adonai Mitchell
– Gameday Inactive
Michael Pittman Jr.
– Glute
Alec Pierce
– Knee
Riley Leonard
– Gameday Inactive
Ashton Dulin
– Concussion
Daniel Jones
– Fibula
Nick Cross
– Hip
DJ Giddens
– Gameday Inactive
Kenny Moore II
– Calf
Khalil Herbert
– Gameday Inactive
Justin Walley
– Knee
JuJu Brents
– Gameday Inactive
Hunter Wohler
– Foot
Tyler Goodson
– Elbow
Samuel Womack III
– Gameday Inactive
Johnathan Edwards
– Gameday Inactive
Salvon Ahmed
– Ankle
Daniel Scott
– Knee
Chris Lammons
– Foot
Jaylon Jones
– Hamstring
Zaire Franklin
– Ankle
Liam Anderson
– Undisclosed
Joe Bachie
– Quadricep
Maddux Trujillo
– Undisclosed
Kwity Paye
– Groin
Samson Ebukam
– Back
Jacob Phillips
– Bicep
Quenton Nelson
– Wrist
Jaylon Carlies
– Ankle
Austin Ajiake
– Throat
Cameron McGrone
– Achilles
Tanor Bortolini
– Concussion
Danny Pinter
– Rib
Luke Tenuta
– Gameday Inactive
Dalton Tucker
– Shoulder
Matt Goncalves
– Personal
Braden Smith
– Groin
Blake Freeland
– Leg
Jack Wilson
– Undisclosed
Bernhard Raimann
– Illness
Jelani Woods
– Gameday Inactive
Tyler Warren
– Toe
Drew Ogletree
– Neck
Will Mallory
– Gameday Inactive
Grover Stewart
– Biceps
JT Tuimoloau
– Gameday Inactive
Neville Gallimore
– Knee
Tyquan Lewis
– Oblique
Laiatu Latu
– Hamstring
Eric Johnson II
– Gameday Inactive
DeForest Buckner
– Back

Current Betting Odds

  • Spread: Colts favored at 3.5
  • Total (Over/Under): 49.5
  • Moneyline Odds: Rams -189 , Colts +159

Recent Matches

Rams
Colts
Date Vs Result Score
09/21/2025 Eagles loss 33 : 26
09/14/2025 Titans win 19 : 33
09/07/2025 Texans win 14 : 9
08/23/2025 Browns loss 19 : 17
08/16/2025 Chargers win 23 : 22
08/09/2025 Cowboys win 31 : 21
01/19/2025 Eagles loss 28 : 22
01/13/2025 Vikings win 27 : 9
01/05/2025 Seahawks loss 25 : 30
12/28/2024 Cardinals win 13 : 9
W - 6
L - 4
Date Vs Result Score
09/21/2025 Titans win 20 : 41
09/14/2025 Broncos win 29 : 28
09/07/2025 Dolphins win 33 : 8
08/23/2025 Bengals win 14 : 41
08/16/2025 Packers loss 19 : 23
08/07/2025 Ravens loss 24 : 16
01/05/2025 Jaguars win 26 : 23
12/29/2024 Giants loss 45 : 33
12/22/2024 Titans win 38 : 30
12/15/2024 Broncos loss 31 : 13
W - 6
L - 4

Who Wins: our Prediction

Based on statistical analysis, we see the Rams at a win probability of 37%, while the Colts have a propability of 63% to win.

Find the best Futures for Rams vs Colts

Statistics

Want Even More Picks To Profit From?
Money Line -116 FanDuel +100 BetMGM
Spread -1.5 -105 DraftKings 1.0 -110 BetMGM
Over/Under -102 FanDuel DraftKings
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Spread 3.5 -102 FanDuel -3.5 -105 BetMGM
Over/Under -108 DraftKings DraftKings
Money Line +130 DraftKings -152 FanDuel
Spread 3.0 -115 BetMGM -3.0 -102 DraftKings
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Spread 10.0 -105 BetMGM -10.5 -104 FanDuel
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Spread -1.5 -105 BetMGM 1.5 -110 FanDuel
Over/Under -108 FanDuel DraftKings
Money Line -180 DraftKings +154 BetMGM
Spread -3.5 +100 DraftKings 3.5 -115 BetMGM
Over/Under -110 FanDuel DraftKings
Money Line +135 BetMGM -150 Fanatics
Spread 2.5 -102 FanDuel -3.0 -102 BetMGM
Over/Under -108 FanDuel DraftKings
Money Line -1299 Fanatics +950 DraftKings
Spread -14.5 +100 FanDuel 14.0 -105 Fanatics
Over/Under -105 Fanatics DraftKings
Money Line -375 BetMGM +320 DraftKings
Spread -7.5 -105 BetMGM 7.5 -105 BetMGM
Over/Under -105 DraftKings DraftKings
Money Line -190 BetMGM +164 DraftKings
Spread -3.5 -105 DraftKings 3.5 -110 Fanatics
Over/Under -105 FanDuel DraftKings
Money Line +187.5 FanDuel -218 DraftKings
Spread 4.5 -114 FanDuel -4.5 -105 DraftKings
Over/Under -102 DraftKings DraftKings
Money Line +370 DraftKings -450 Fanatics
Spread 8.5 -105 FanDuel -8.5 -108 DraftKings
Over/Under -108 FanDuel DraftKings
Money Line +300 BetMGM -350 FanDuel
Spread 7.0 -102 FanDuel -7.5 +100 DraftKings
Over/Under -108 DraftKings DraftKings
Money Line +810 FanDuel -1000 BetMGM
Spread 13.5 -106 FanDuel -13.5 -105 DraftKings
Over/Under -105 DraftKings DraftKings
Money Line -115 Fanatics +102 FanDuel
Spread -1.5 -105 DraftKings 1.5 -110 FanDuel
Over/Under -110 FanDuel DraftKings
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