Colts– is set for Sunday, October 19, 2025 at 4:05 pm ET. Sportsbooks list Point Spread Colts and Total 48.5 M/L: Colts -141, Chargers +120 is available. Lines are posted across books.
Money Line-135+120
Spread
-2.5
-110
2.5
-105
Over/Under
-105
Matchup Overview
Teams: Chargers vs Colts
Date: Sunday, October 19, 2025
Time: 04:05 pm ET
Venue: SoFi Stadium
Where To Watch Chargers vs Colts on Sunday
Watch the full match on CBS.
Injuries
Chargers
Colts
Daiyan Henley
– Groin
Quentin Johnston
– Concussion
Elijah Molden
– Knee
Derwin James Jr.
– Glute
Denzel Perryman
– Ankle
Omarion Hampton
– Ankle
Tre Harris
– Jaw
Justin Herbert
– Hand
Derius Davis
– Knee
Ladd McConkey
– Biceps
Cam Hart
– Hip
Najee Harris
– Eye
Tony Jefferson
– Hamstring
Benjamin St-Juste
– Groin
Junior Colson
– Shoulder
Donte Jackson
– Ankle
RJ Mickens
– Gameday Inactive
Hassan Haskins
– Chest
Tarheeb Still
– Ankle
Kimani Vidal
– Neck
Trikweze Bridges
– Knee
Deane Leonard
– Undisclosed
Raheim Sanders
– Gameday Inactive
Jaylen Jones
– Undisclosed
Ja'Sir Taylor
– Illness
Jordan Oladokun
– Undisclosed
Emany Johnson
– Gameday Inactive
Dalevon Campbell
– Gameday Inactive
Eric Rogers
– Undisclosed
Kendall Williamson
– Achilles
Tucker Fisk
– Gameday Inactive
Troy Dye
– Thumb
Scott Matlock
– Ankle
McCallan Castles
– Undisclosed
Nikko Reed
– Gameday Inactive
Josh Harris
– Undisclosed
Bud Dupree
– Hamstring
Jordan Petaia
– Undisclosed
Caleb Murphy
– Gameday Inactive
Khalil Mack
– Elbow
Del'Shawn Phillips
– Undisclosed
Kyle Kennard
– Gameday Inactive
Kana'i Mauga
– Gameday Inactive
Jamaree Salyer
– Knee
Josh Fuga
– Undisclosed
Rashawn Slater
– Knee
Branson Taylor
– Gameday Inactive
M.Becton
– Illness
Bradley Bozeman
– Back
Joe Alt
– Ankle
Andre James
– Neck
Trey Pipkins III
– Knee
Brenden Rice
– Undisclosed
Tyler Conklin
– Calf
Keandre Lambert-Smith
– Gameday Inactive
Oronde Gadsden
– Gameday Inactive
Dez Fitzpatrick
– Undisclosed
Jalen Reagor
– Undisclosed
Will Dissly
– Knee
Teair Tart
– Groin
Da'Shawn Hand
– Back
Justin Eboigbe
– Foot
Otito Ogbonnia
– Gameday Inactive
Naquan Jones
– Gameday Inactive
Jamaree Caldwell
– Illness
Josh Downs
– Hamstring
D.J. Montgomery
– Undisclosed
Spencer Shrader
– Knee
Anthony Richardson Sr.
– Eye
Anthony Gould
– Illness
Charvarius Ward
– Concussion
Rigoberto Sanchez
– Personal
Adonai Mitchell
– Gameday Inactive
Michael Pittman Jr.
– Glute
Alec Pierce
– Knee
Riley Leonard
– Gameday Inactive
Ashton Dulin
– Concussion
Daniel Jones
– Fibula
Nick Cross
– Hip
DJ Giddens
– Gameday Inactive
Kenny Moore II
– Calf
Khalil Herbert
– Gameday Inactive
Justin Walley
– Knee
JuJu Brents
– Gameday Inactive
Hunter Wohler
– Foot
Tyler Goodson
– Elbow
Samuel Womack III
– Gameday Inactive
Johnathan Edwards
– Gameday Inactive
Salvon Ahmed
– Ankle
Daniel Scott
– Knee
Chris Lammons
– Foot
Jaylon Jones
– Hamstring
Zaire Franklin
– Ankle
Liam Anderson
– Undisclosed
Joe Bachie
– Quadricep
Maddux Trujillo
– Undisclosed
Sean McKeon
– Shoulder
Kwity Paye
– Groin
Samson Ebukam
– Back
Jacob Phillips
– Bicep
Quenton Nelson
– Wrist
Jaylon Carlies
– Ankle
Austin Ajiake
– Throat
Cameron McGrone
– Achilles
Tanor Bortolini
– Concussion
Danny Pinter
– Rib
Luke Tenuta
– Gameday Inactive
Dalton Tucker
– Shoulder
Matt Goncalves
– Personal
Braden Smith
– Groin
Blake Freeland
– Leg
Jack Wilson
– Undisclosed
Bernhard Raimann
– Illness
Jelani Woods
– Gameday Inactive
Tyler Warren
– Toe
Drew Ogletree
– Neck
Will Mallory
– Gameday Inactive
Grover Stewart
– Biceps
JT Tuimoloau
– Gameday Inactive
Neville Gallimore
– Knee
Tyquan Lewis
– Oblique
Laiatu Latu
– Hamstring
Eric Johnson II
– Gameday Inactive
DeForest Buckner
– Back
Current Betting Odds
Spread: Colts favored at 2.5
Total (Over/Under): 48.5
Moneyline Odds: Chargers -141 , Colts +120
Recent Matches
Chargers
Colts
Date
Vs
Result
Score
10/12/2025
Dolphins
win
27 :
29
10/05/2025
Commanders
loss
10
: 27
09/28/2025
Giants
loss
21 :
18
09/21/2025
Broncos
win
23
: 20
09/15/2025
Raiders
win
9 :
20
09/05/2025
Chiefs
win
27
: 21
08/23/2025
49ers
loss
30 :
23
08/16/2025
Rams
loss
23 :
22
08/10/2025
Saints
win
27
: 13
07/31/2025
Lions
win
7 :
34
W - 6
L - 4
Date
Vs
Result
Score
10/12/2025
Cardinals
win
31
: 27
10/05/2025
Raiders
win
40
: 6
09/28/2025
Rams
loss
27 :
20
09/21/2025
Titans
win
20 :
41
09/14/2025
Broncos
win
29
: 28
09/07/2025
Dolphins
win
33
: 8
08/23/2025
Bengals
win
14 :
41
08/16/2025
Packers
loss
19
: 23
08/07/2025
Ravens
loss
24 :
16
01/05/2025
Jaguars
win
26
: 23
W - 7
L - 3
Who Wins: our Prediction
Based on statistical analysis, we see the Chargers at a win probability of 44%, while the Colts have a propability of 56% to win.
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