Browns and Packers meet Sunday, September 21, 2025, 1:00 pm ET. Vegas lists Point Spread Browns ; O/U 41 ML: Packers +332, Browns -427 is posted. Pricing is consistent across leading sportsbooks.
Money Line+350-380
Spread
7.0
-105
-7.5
-105
Over/Under
-110
Matchup Overview
Teams: Browns vs Packers
Date: Sunday, September 21, 2025
Time: 01:00 pm ET
Venue: Huntington Bank Field
Where To Watch Browns vs Packers on Sunday
The match will be broadcast by FOX.
Injuries
Browns
Packers
Greg Newsome II
– Shoulder
Martin Emerson Jr.
– Achilles
DeAndre Carter
– Knee
Jerry Jeudy
– Knee
Deshaun Watson
– Achilles
Dillon Gabriel
– Concussion
Jeremiah Owusu-Koramoah
– Neck
K.Pickett
– Hamstring
Grant Delpit
– Back
Quinshon Judkins
– Not Injury Related
Shedeur Sanders
– Gameday Inactive
Corey Bojorquez
– Right Ankle
Joe Flacco
– Right Shoulder/Right Finger
Jerome Baker
– Achilles
David Bell
– Undisclosed
Cedric Tillman
– Thumb
Pierre Strong Jr.
– Undisclosed
Denzel Ward
– Shoulder
Dylan Sampson
– Calf
Damontae Kazee
– Gameday Inactive
Myles Harden
– Ankle
Rayshawn Jenkins
– Wrist
Cameron Mitchell
– Gameday Inactive
Devin Bush
– Foot
Cade McDonald
– Undisclosed
Jerome Ford
– Shoulder
Dom Jones
– Knee
Nathaniel Watson
– Biceps
Easton Mascarenas-Arnold
– Achilles
Mohamoud Diabate
– Quad
Anthony Kendall
– Undisclosed
Andre Szmyt
– Left Calf
Carson Schwesinger
– Ankle
Mike Hall Jr.
– Undisclosed
Julian Okwara
– Undisclosed
Ethan Pocic
– Knee
Isaiah McGuire
– Knee
Winston Reid
– Back
Adin Huntington
– Concussion
Lorenzo Thompson
– Undisclosed
Zak Zinter
– Gameday Inactive
Cornelius Lucas
– Ankle
Teven Jenkins
– Shoulder
Joel Bitonio
– Back
Wyatt Teller
– Calf
Jack Conklin
– Elbow
Dawand Jones
– Knee
Jamari Thrash
– Gameday Inactive
Brenden Bates
– Gameday Inactive
Gage Larvadain
– Gameday Inactive
David Njoku
– Knee
Blake Whiteheart
– Knee
Harold Fannin Jr.
– Hamstring
Joe Tryon-Shoyinka
– Gameday Inactive
Alex Wright
– Quad
Sam Kamara
– Gameday Inactive
Shelby Harris
– Illness
Mason Graham
– Shoulder
Myles Garrett
– Ankle
Maliek Collins
– Quadricep
Malik Willis
– Calf
Mecole Hardman
– Calf
Quay Walker
– Quadricep
Josh Jacobs
– Ankle
Christian Watson
– Knee
Jordan Love
– Thumb
Jayden Reed
– Foot
Dontayvion Wicks
– Calf
Bo Melton
– Shoulder
Sean Clifford
– Gameday Inactive
Brandon McManus
– Right Quadriceps
Sam Brown Jr.
– Ankle
Malik Heath
– Hip
Daniel Whelan
– Right Knee
Javon Bullard
– Concussion
Nate Hobbs
– Knee
Matthew Golden
– Ankle
Keisean Nixon
– Illness
Micah Robinson
– Illness
Xavier McKinney
– Calf
Chris Brooks
– Hamstring
Emanuel Wilson
– Illness
MarShawn Lloyd
– Hamstring
Evan Williams
– Back
Kalen King
– Gameday Inactive
Jalen White
– Foot
Kamal Hadden
– Gameday Inactive
Gregory Junior
– Undisclosed
Zayne Anderson
– Knee
Omar Brown
– Lung
Matt Orzech
– Calf
Collin Oliver
– Undisclosed
Tyron Herring
– Undisclosed
Isaiah Dunn
– Undisclosed
Jamon Johnson
– Gameday Inactive
Zach Tom
– Oblique
Jared Bartlett
– Undisclosed
Arron Mosby
– Ankle
Kristian Welch
– Concussion
Kingsley Enagbare
– Ankle
Edgerrin Cooper
– Shoulder
Brenton Cox Jr.
– Groin
Keith Randolph
– Undisclosed
Jacob Monk
– Hamstring
Rasheed Walker
– Quad
Aaron Banks
– Back
Donovan Jennings
– Gameday Inactive
Anthony Belton
– Ankle
Brant Banks
– Gameday Inactive
John Williams
– Undisclosed
Elgton Jenkins
– Undisclosed
Sean Rhyan
– Knee
Jordan Morgan
– Knee
Travis Glover
– Shoulder
Savion Williams
– Hamstring
Tucker Kraft
– Elbow/Knee
John FitzPatrick
– Groin
Romeo Doubs
– Chest
Luke Musgrave
– Neck
Ben Sims
– Gameday Inactive
Lukas Van Ness
– Foot
Warren Brinson
– Gameday Inactive
Nazir Stackhouse
– Undisclosed
Karl Brooks
– Foot
Devonte Wyatt
– Knee
Colby Wooden
– Shoulder
Kenny Clark
– Ankle
Barryn Sorrell
– Knee
Current Betting Odds
Spread: Browns favored at 7.5
Total (Over/Under): 41
Moneyline Odds: Browns +332 , Packers -427
Recent Matches
Browns
Packers
Date
Vs
Result
Score
09/14/2025
Ravens
loss
41 :
17
09/07/2025
Bengals
loss
16
: 17
08/23/2025
Rams
win
19
: 17
08/16/2025
Eagles
win
13 :
22
08/08/2025
Panthers
win
10 :
30
01/04/2025
Ravens
loss
35 :
10
12/29/2024
Dolphins
loss
3
: 20
12/22/2024
Bengals
loss
24 :
6
12/15/2024
Chiefs
loss
7
: 21
12/08/2024
Steelers
loss
27 :
14
W - 3
L - 7
Date
Vs
Result
Score
09/11/2025
Commanders
win
27
: 18
09/07/2025
Lions
win
27
: 13
08/23/2025
Seahawks
win
20
: 7
08/16/2025
Colts
win
19 :
23
08/09/2025
Jets
loss
10
: 30
01/12/2025
Eagles
loss
22 :
10
01/05/2025
Bears
loss
22
: 24
12/29/2024
Vikings
loss
27 :
25
12/23/2024
Saints
win
34
: 0
12/15/2024
Seahawks
win
13 :
30
W - 6
L - 4
Who Wins: our Prediction
Based on statistical analysis, we see the Browns at a win probability of 78%, while the Packers have a propability of 22% to win.
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