Bills vs Lions NFL Week 2 – Match Preview & Live Updates Thursday, September 17, 2026

National Football League
Bills
Home
17/09/2026
8:15pm
Lions
Away

Bills vs. Lions: Detailed Breakdown

Lions host Bills this Thursday at Highmark Stadium. Books show point spread (Lions ) and total sitting at 54.5. M/L: Lions -244, Bills +200. Numbers reflect current sportsbook listings at the time of writing.

Money Line -240 FanDuel +200 BetMGM
Spread -5.5 -105 FanDuel 5.0 -102 BetMGM
Over/Under -112 BetMGM BetMGM

Matchup Overview

  • Teams: Bills vs Lions
  • Date: Thursday, September 17, 2026
  • Time: 08:15 pm ET
  • Venue: Highmark Stadium

Where To Watch Bills vs Lions on Thursday

Watch the full match on AMZN.

Injuries

Bills
Lions

Current Betting Odds

  • Spread: Lions favored at 5.5
  • Total (Over/Under): 54.5
  • Moneyline Odds: Bills -244 , Lions +200

Recent Matches

Bills
Lions
Date Vs Result Score
09/13/2026 Texans win 31 : 36
08/27/2026 Steelers win 28 : 27
08/22/2026 Browns win 7 : 31
08/15/2026 Panthers win 29 : 14
01/17/2026 Broncos loss 33 : 30
01/11/2026 Jaguars win 24 : 27
01/04/2026 Jets win 35 : 8
12/28/2025 Eagles loss 12 : 13
12/21/2025 Browns win 20 : 23
12/14/2025 Patriots win 31 : 35
W - 8
L - 2
Date Vs Result Score
09/13/2026 Saints win 31 : 30
08/29/2026 Colts win 16 : 25
08/22/2026 Commanders win 17 : 13
08/13/2026 Bengals loss 16 : 14
01/04/2026 Bears win 16 : 19
12/25/2025 Vikings loss 23 : 10
12/21/2025 Steelers loss 24 : 29
12/14/2025 Rams loss 41 : 34
12/04/2025 Cowboys win 44 : 30
11/27/2025 Packers loss 24 : 31
W - 5
L - 5

Who Wins: our Prediction

Based on statistical analysis, we see the Bills at a win probability of 32%, while the Lions have a propability of 68% to win.

Find the best Futures for Bills vs Lions

Statistics

Want Even More Picks To Profit From?
Money Line -400 FanDuel +320 BetMGM
Spread -8.0 -108 BetMGM 7.5 -110 FanDuel
Over/Under -108 BetMGM FanDuel
Money Line +102 FanDuel -120 BetMGM
Spread 1.5 -110 BetMGM -1.5 -108 BetMGM
Over/Under -105 BetMGM BetMGM
Money Line -190 BetMGM +160 FanDuel
Spread -3.5 -108 BetMGM 3.5 -108 FanDuel
Over/Under -110 BetMGM BetMGM
Money Line +295 FanDuel -370 FanDuel
Spread 7.0 -105 FanDuel -7.0 -110 BetMGM
Over/Under -108 BetMGM BetMGM
Money Line +275 BetMGM -340 FanDuel
Spread 7.0 -110 BetMGM -7.0 -108 BetMGM
Over/Under -112 BetMGM BetMGM
Money Line +116 FanDuel -130 Fanatics
Spread 1.5 -102 FanDuel -2.0 -110 BetMGM
Over/Under -104 FanDuel BetMGM
Money Line -145 BetMGM +125 BetMGM
Spread -3.0 -102 BetMGM 2.5 +100 Fanatics
Over/Under -108 BetMGM BetMGM
Money Line -134 FanDuel +115 BetMGM
Spread -2.0 -110 BetMGM 1.5 -102 FanDuel
Over/Under -110 BetMGM BetMGM
Money Line -184 FanDuel +155 BetMGM
Spread -3.5 -108 BetMGM 3.5 -110 BetMGM
Over/Under -110 BetMGM BetMGM
Money Line +160 Fanatics -186 FanDuel
Spread 3.5 -110 BetMGM -3.5 -108 BetMGM
Over/Under -105 FanDuel BetMGM
Money Line -165 BetMGM +146 FanDuel
Spread -3.0 -112 BetMGM 3.0 -104 FanDuel
Over/Under -105 FanDuel BetMGM
Money Line +200 BetMGM -245 FanDuel
Spread 5.0 -108 BetMGM -5.5 -105 FanDuel
Over/Under -108 FanDuel FanDuel
Money Line -168 FanDuel +145 BetMGM
Spread -3.5 +100 Fanatics 3.0 -102 BetMGM
Over/Under -110 BetMGM BetMGM
Money Line -175 BetMGM +150 Fanatics
Spread -3.5 +100 Fanatics 3.5 -115 BetMGM
Over/Under -108 BetMGM Fanatics
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