Chargers vs Broncos NFL Week 3 – Match Preview & Live Updates Sunday, September 21, 2025

National Football League
Chargers
Home
21/09/2025
4:05pm
Broncos
Away

Chargers vs. Broncos: Detailed Breakdown

Chargers travel to Broncos for Sunday’s game. Books post Point Spread Broncos and Total 45.5 M/L: Broncos -149, Chargers +126 is on offer. Kick time is 4:05 pm ET.

Money Line -150 Fanatics +132 FanDuel
Spread -2.5 -120 DraftKings 2.5 +100 DraftKings
Over/Under -110 DraftKings DraftKings

Matchup Overview

  • Teams: Chargers vs Broncos
  • Date: Sunday, September 21, 2025
  • Time: 04:05 pm ET
  • Venue: SoFi Stadium

Where To Watch Chargers vs Broncos on Sunday

Watch the full match on CBS.

Injuries

Chargers
Broncos
Daiyan Henley
– Groin
Quentin Johnston
– Concussion
Elijah Molden
– Knee
Derwin James Jr.
– Glute
Denzel Perryman
– Ankle
Omarion Hampton
– Ankle
Tre Harris
– Jaw
Justin Herbert
– Hand
Derius Davis
– Knee
Ladd McConkey
– Biceps
Cam Hart
– Hip
Najee Harris
– Eye
Tony Jefferson
– Hamstring
Benjamin St-Juste
– Groin
Junior Colson
– Shoulder
Donte Jackson
– Ankle
RJ Mickens
– Gameday Inactive
Hassan Haskins
– Chest
Tarheeb Still
– Ankle
Kimani Vidal
– Neck
Trikweze Bridges
– Knee
Deane Leonard
– Undisclosed
Raheim Sanders
– Gameday Inactive
Jaylen Jones
– Undisclosed
Ja'Sir Taylor
– Illness
Jordan Oladokun
– Undisclosed
Emany Johnson
– Gameday Inactive
Dalevon Campbell
– Gameday Inactive
Eric Rogers
– Undisclosed
Kendall Williamson
– Achilles
Tucker Fisk
– Gameday Inactive
Troy Dye
– Thumb
Scott Matlock
– Ankle
McCallan Castles
– Undisclosed
Nikko Reed
– Gameday Inactive
Josh Harris
– Undisclosed
Bud Dupree
– Hamstring
Jordan Petaia
– Undisclosed
Caleb Murphy
– Gameday Inactive
Khalil Mack
– Elbow
Del'Shawn Phillips
– Undisclosed
Kyle Kennard
– Gameday Inactive
Kana'i Mauga
– Gameday Inactive
Jamaree Salyer
– Knee
Josh Fuga
– Undisclosed
Rashawn Slater
– Knee
Branson Taylor
– Gameday Inactive
M.Becton
– Illness
Bradley Bozeman
– Back
Joe Alt
– Ankle
Andre James
– Neck
Trey Pipkins III
– Knee
Tyler Conklin
– Gameday Inactive
Keandre Lambert-Smith
– Gameday Inactive
Oronde Gadsden
– Gameday Inactive
Dez Fitzpatrick
– Undisclosed
Jalen Reagor
– Undisclosed
Will Dissly
– Knee
Teair Tart
– Groin
Da'Shawn Hand
– Back
Justin Eboigbe
– Foot
Otito Ogbonnia
– Gameday Inactive
Naquan Jones
– Gameday Inactive
Jamaree Caldwell
– Illness
Johnny Walker Jr.
– Lower Body
Jonathon Cooper
– Quad
Evan Engram
– Calf
Pat Surtain II
– Leg
Wil Lutz
– Illness
Sam Ehlinger
– Gameday Inactive
Trent Sherfield Sr.
– Toe
P.J. Locke
– Neck
Talanoa Hufanga
– Chest
Bo Nix
– Ankle
Troy Franklin
– Hamstring
Pat Bryant
– Concussion
Nik Bonitto
– Foot
Devaughn Vele
– Hip
Marvin Mims Jr.
– Thigh
Michael Burton
– Hamstring
Riley Moss
– Ankle
Brandon Jones
– Foot
Audric Estime
– Gameday Inactive
Blake Watson
– Undisclosed
J.K. Dobbins
– Foot
Damarri Mathis
– Knee
Tyler Badie
– Shoulder
Delarrin Turner-Yell
– Knee
JL Skinner
– Quad
Reese Taylor
– Gameday Inactive
RJ Harvey
– Ribs
Jaleel McLaughlin
– Gameday Inactive
Justin Strnad
– Foot
Drew Sanders
– Foot
Sam Franklin Jr.
– Illness
Nate Adkins
– Ankle
Garret Wallow
– Hamstring
Karene Reid
– Hamstring
Alex Singleton
– Thumb
Que Robinson
– Gameday Inactive
Jonah Elliss
– Hamstring
Alex Forsyth
– Ankle
Dre Greenlaw
– Quad
Luke Wattenberg
– Ankle
Nick Gargiulo
– Knee
Mike McGlinchey
– Ankle/Foot
Xavier Truss
– Gameday Inactive
Frank Crum
– Gameday Inactive
Ben Powers
– Bicep
Kristian Williams
– Undisclosed
Quinn Meinerz
– Illness
Matt Peart
– Knee
Caleb Lohner
– Gameday Inactive
Lucas Krull
– Gameday Inactive
A.T. Perry
– Undisclosed
Matt Henningsen
– Achilles
Dondrea Tillman
– Hamstring
D.J. Jones
– Shoulder
Jordan Jackson
– Gameday Inactive
Sai'vion Jones
– Gameday Inactive
Malcolm Roach
– Calf
John Franklin-Myers
– Knee
Zach Allen
– Calf

Current Betting Odds

  • Spread: Broncos favored at 2.5
  • Total (Over/Under): 45.5
  • Moneyline Odds: Chargers -149 , Broncos +126

Recent Matches

Chargers
Broncos
Date Vs Result Score
09/15/2025 Raiders win 9 : 20
09/05/2025 Chiefs win 27 : 21
08/23/2025 49ers loss 30 : 23
08/16/2025 Rams loss 23 : 22
08/10/2025 Saints win 27 : 13
07/31/2025 Lions win 7 : 34
01/11/2025 Texans loss 32 : 12
01/05/2025 Raiders win 20 : 34
12/28/2024 Patriots win 7 : 40
12/19/2024 Broncos win 34 : 27
W - 7
L - 3
Date Vs Result Score
09/14/2025 Colts loss 29 : 28
09/07/2025 Titans win 20 : 12
08/23/2025 Saints win 19 : 28
08/16/2025 Cardinals win 27 : 7
08/09/2025 49ers win 9 : 30
01/12/2025 Bills loss 31 : 7
01/05/2025 Chiefs win 38 : 0
12/28/2024 Bengals loss 30 : 24
12/19/2024 Chargers loss 34 : 27
12/15/2024 Colts win 31 : 13
W - 6
L - 4

Who Wins: our Prediction

Based on statistical analysis, we see the Chargers at a win probability of 43%, while the Broncos have a propability of 57% to win.

Find the best Futures for Chargers vs Broncos

Statistics

Want Even More Picks To Profit From?
Money Line -116 FanDuel +100 BetMGM
Spread -1.5 -105 DraftKings 1.0 -110 BetMGM
Over/Under -102 FanDuel DraftKings
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Spread 3.5 -102 FanDuel -3.5 -105 BetMGM
Over/Under -108 DraftKings DraftKings
Money Line +130 DraftKings -152 FanDuel
Spread 3.0 -115 BetMGM -3.0 -102 DraftKings
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Money Line +455 DraftKings -592 FanDuel
Spread 10.0 -105 BetMGM -10.5 -104 FanDuel
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Spread -1.5 -105 BetMGM 1.5 -110 FanDuel
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Money Line -180 DraftKings +154 BetMGM
Spread -3.5 +100 DraftKings 3.5 -115 BetMGM
Over/Under -110 FanDuel DraftKings
Money Line +135 BetMGM -150 Fanatics
Spread 2.5 -102 FanDuel -3.0 -102 BetMGM
Over/Under -108 FanDuel DraftKings
Money Line -1299 Fanatics +950 DraftKings
Spread -14.5 +100 FanDuel 14.0 -105 Fanatics
Over/Under -105 Fanatics DraftKings
Money Line -375 BetMGM +320 DraftKings
Spread -7.5 -105 BetMGM 7.5 -105 BetMGM
Over/Under -105 DraftKings DraftKings
Money Line -190 BetMGM +164 DraftKings
Spread -3.5 -105 DraftKings 3.5 -110 Fanatics
Over/Under -105 FanDuel DraftKings
Money Line +187.5 FanDuel -218 DraftKings
Spread 4.5 -114 FanDuel -4.5 -105 DraftKings
Over/Under -102 DraftKings DraftKings
Money Line +370 DraftKings -450 Fanatics
Spread 8.5 -105 FanDuel -8.5 -108 DraftKings
Over/Under -108 FanDuel DraftKings
Money Line +300 BetMGM -350 FanDuel
Spread 7.0 -102 FanDuel -7.5 +100 DraftKings
Over/Under -108 DraftKings DraftKings
Money Line +810 FanDuel -1000 BetMGM
Spread 13.5 -106 FanDuel -13.5 -105 DraftKings
Over/Under -105 DraftKings DraftKings
Money Line -115 Fanatics +102 FanDuel
Spread -1.5 -105 DraftKings 1.5 -110 FanDuel
Over/Under -110 FanDuel DraftKings
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