Chargers travel to Broncos for Sunday’s game. Books post Point Spread Broncos and Total 45.5 M/L: Broncos -149, Chargers +126 is on offer. Kick time is 4:05 pm ET.
Money Line-150+132
Spread
-2.5
-120
2.5
+100
Over/Under
-110
Matchup Overview
Teams: Chargers vs Broncos
Date: Sunday, September 21, 2025
Time: 04:05 pm ET
Venue: SoFi Stadium
Where To Watch Chargers vs Broncos on Sunday
Watch the full match on CBS.
Injuries
Chargers
Broncos
Daiyan Henley
– Groin
Quentin Johnston
– Concussion
Elijah Molden
– Knee
Derwin James Jr.
– Glute
Denzel Perryman
– Ankle
Omarion Hampton
– Ankle
Tre Harris
– Jaw
Justin Herbert
– Hand
Derius Davis
– Knee
Ladd McConkey
– Biceps
Cam Hart
– Hip
Najee Harris
– Eye
Tony Jefferson
– Hamstring
Benjamin St-Juste
– Groin
Junior Colson
– Shoulder
Donte Jackson
– Ankle
RJ Mickens
– Gameday Inactive
Hassan Haskins
– Chest
Tarheeb Still
– Ankle
Kimani Vidal
– Neck
Trikweze Bridges
– Knee
Deane Leonard
– Undisclosed
Raheim Sanders
– Gameday Inactive
Jaylen Jones
– Undisclosed
Ja'Sir Taylor
– Illness
Jordan Oladokun
– Undisclosed
Emany Johnson
– Gameday Inactive
Dalevon Campbell
– Gameday Inactive
Eric Rogers
– Undisclosed
Kendall Williamson
– Achilles
Tucker Fisk
– Gameday Inactive
Troy Dye
– Thumb
Scott Matlock
– Ankle
McCallan Castles
– Undisclosed
Nikko Reed
– Gameday Inactive
Josh Harris
– Undisclosed
Bud Dupree
– Hamstring
Jordan Petaia
– Undisclosed
Caleb Murphy
– Gameday Inactive
Khalil Mack
– Elbow
Del'Shawn Phillips
– Undisclosed
Kyle Kennard
– Gameday Inactive
Kana'i Mauga
– Gameday Inactive
Jamaree Salyer
– Knee
Josh Fuga
– Undisclosed
Rashawn Slater
– Knee
Branson Taylor
– Gameday Inactive
M.Becton
– Illness
Bradley Bozeman
– Back
Joe Alt
– Ankle
Andre James
– Neck
Trey Pipkins III
– Knee
Tyler Conklin
– Gameday Inactive
Keandre Lambert-Smith
– Gameday Inactive
Oronde Gadsden
– Gameday Inactive
Dez Fitzpatrick
– Undisclosed
Jalen Reagor
– Undisclosed
Will Dissly
– Knee
Teair Tart
– Groin
Da'Shawn Hand
– Back
Justin Eboigbe
– Foot
Otito Ogbonnia
– Gameday Inactive
Naquan Jones
– Gameday Inactive
Jamaree Caldwell
– Illness
Johnny Walker Jr.
– Lower Body
Jonathon Cooper
– Quad
Evan Engram
– Calf
Pat Surtain II
– Leg
Wil Lutz
– Illness
Sam Ehlinger
– Gameday Inactive
Trent Sherfield Sr.
– Toe
P.J. Locke
– Neck
Talanoa Hufanga
– Chest
Bo Nix
– Ankle
Troy Franklin
– Hamstring
Pat Bryant
– Concussion
Nik Bonitto
– Foot
Devaughn Vele
– Hip
Marvin Mims Jr.
– Thigh
Michael Burton
– Hamstring
Riley Moss
– Ankle
Brandon Jones
– Foot
Audric Estime
– Gameday Inactive
Blake Watson
– Undisclosed
J.K. Dobbins
– Foot
Damarri Mathis
– Knee
Tyler Badie
– Shoulder
Delarrin Turner-Yell
– Knee
JL Skinner
– Quad
Reese Taylor
– Gameday Inactive
RJ Harvey
– Ribs
Jaleel McLaughlin
– Gameday Inactive
Justin Strnad
– Foot
Drew Sanders
– Foot
Sam Franklin Jr.
– Illness
Nate Adkins
– Ankle
Garret Wallow
– Hamstring
Karene Reid
– Hamstring
Alex Singleton
– Thumb
Que Robinson
– Gameday Inactive
Jonah Elliss
– Hamstring
Alex Forsyth
– Ankle
Dre Greenlaw
– Quad
Luke Wattenberg
– Ankle
Nick Gargiulo
– Knee
Mike McGlinchey
– Ankle/Foot
Xavier Truss
– Gameday Inactive
Frank Crum
– Gameday Inactive
Ben Powers
– Bicep
Kristian Williams
– Undisclosed
Quinn Meinerz
– Illness
Matt Peart
– Knee
Caleb Lohner
– Gameday Inactive
Lucas Krull
– Gameday Inactive
A.T. Perry
– Undisclosed
Matt Henningsen
– Achilles
Dondrea Tillman
– Hamstring
D.J. Jones
– Shoulder
Jordan Jackson
– Gameday Inactive
Sai'vion Jones
– Gameday Inactive
Malcolm Roach
– Calf
John Franklin-Myers
– Knee
Zach Allen
– Calf
Current Betting Odds
Spread: Broncos favored at 2.5
Total (Over/Under): 45.5
Moneyline Odds: Chargers -149 , Broncos +126
Recent Matches
Chargers
Broncos
Date
Vs
Result
Score
09/15/2025
Raiders
win
9 :
20
09/05/2025
Chiefs
win
27
: 21
08/23/2025
49ers
loss
30 :
23
08/16/2025
Rams
loss
23 :
22
08/10/2025
Saints
win
27
: 13
07/31/2025
Lions
win
7 :
34
01/11/2025
Texans
loss
32 :
12
01/05/2025
Raiders
win
20 :
34
12/28/2024
Patriots
win
7 :
40
12/19/2024
Broncos
win
34
: 27
W - 7
L - 3
Date
Vs
Result
Score
09/14/2025
Colts
loss
29 :
28
09/07/2025
Titans
win
20
: 12
08/23/2025
Saints
win
19 :
28
08/16/2025
Cardinals
win
27
: 7
08/09/2025
49ers
win
9 :
30
01/12/2025
Bills
loss
31 :
7
01/05/2025
Chiefs
win
38
: 0
12/28/2024
Bengals
loss
30 :
24
12/19/2024
Chargers
loss
34 :
27
12/15/2024
Colts
win
31
: 13
W - 6
L - 4
Who Wins: our Prediction
Based on statistical analysis, we see the Chargers at a win probability of 43%, while the Broncos have a propability of 57% to win.
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