Bears host 49ers on Sunday, December 28, 2025. Books show Point Spread Bears and O/U 51.5 ML: Bears -195, 49ers +164 is also posted. Numbers reflect current listings from sportsbooks.
Money Line-190+176
Spread
-3.5
-110
3.5
-105
Over/Under
-105
Matchup Overview
Teams: 49ers vs Bears
Date: Sunday, December 28, 2025
Time: 08:20 pm ET
Venue: Levi's Stadium
Where To Watch 49ers vs Bears on Sunday
Watch the full match on NBC.
Injuries
49ers
Bears
Ameer Abdullah
– Ribs
Isaiah Prince
– Knee
Tre Tomlinson
– Undisclosed
Carter Bradley
– Undisclosed
Renardo Green
– Neck
Ricky Pearsall
– Knee
Deommodore Lenoir
– Hip
Kurtis Rourke
– Knee
Demarcus Robinson
– Suspended
Malik Mustapha
– Knee
Thomas Morstead
– Back
Mac Jones
– Knee
Brandon Aiyuk
– Personal
Brock Purdy
– Left Shoulder/Toe
Tanner Mordecai
– Undisclosed
Jauan Jennings
– Calf
Jordan Watkins
– Gameday Inactive
Jacob Cowing
– Hamstring
Upton Stout
– Calf
Tre Brown
– Heel
Christian McCaffrey
– Calf
Richie Grant
– Knee
Jason Pinnock
– Heel
Chase Lucas
– Undisclosed
Ji'Ayir Brown
– Hamstring
Darrell Luter Jr.
– Achilles
Jordan James
– Gameday Inactive
Eli Apple
– Gameday Inactive
Isaac Guerendo
– Gameday Inactive
Patrick Taylor Jr.
– Shoulder
Siran Neal
– Head
Dallis Flowers
– Undisclosed
Marques Sigle
– Gameday Inactive
Kyle Juszczyk
– Concussion
Nick Martin
– Gameday Inactive
Chazz Surratt
– Ankle
B.Huff
– Ankle
Tatum Bethune
– Thigh
Corey Kiner
– Undisclosed
Jakob Robinson
– Forearm
Robert Beal Jr.
– Gameday Inactive
Dee Winters
– Knee
Fred Warner
– Ankle
Drew Moss
– Gameday Inactive
Sebastian Valdez
– Gameday Inactive
Tarron Jackson
– Neck
Luke Gifford
– Knee
Curtis Robinson
– Knee
Matt Hennessy
– Neck
Austen Pleasants
– Gameday Inactive
Jake Brendel
– Hamstring
A.Dillard
– Undisclosed
Isaac Alarcon
– Suspension
Colton McKivitz
– Calf
Trent Williams
– Knee
Spencer Burford
– Knee
Connor Colby
– Gameday Inactive
Dominick Puni
– Knee
Ben Bartch
– Undisclosed
Trent Taylor
– Undisclosed
George Kittle
– Achilles
Mason Pline
– Undisclosed
Kevin Givens
– Pectoral
Sam Okuayinonu
– Shoulder
Jordan Elliott
– Ankle
Kalia Davis
– Groin
Yetur Gross-Matos
– Undisclosed
Alfred Collins
– Shoulder
Jonathan Garvin
– Undisclosed
Nick Bosa
– Neck
Mykel Williams
– Knee
CJ West
– Knee
Jaylon Johnson
– Undisclosed
DJ Moore
– Abdomen/Groin
D'Andre Swift
– Quad
Kyler Gordon
– Hamstring
Cairo Santos
– Right Thigh
Jaquan Brisker
– Quad
Case Keenum
– Leg
Devin Duvernay
– Hamstring
Olamide Zaccheaus
– Knee
Rome Odunze
– Ankle/Heel
Tyson Bagent
– Illness
Zah Frazier
– Personal
Jahdae Walker
– Ankle
Travis Homer
– Calf
Elijah Hicks
– Shin
Roschon Johnson
– Foot
Nick McCloud
– Illness
Nahshon Wright
– Hip
Kyle Monangai
– Ankle
Shaun Wade
– Undisclosed
Swayze Bozeman
– Ankle
Tyrique Stevenson
– Hip/Calf
Kevin Byard III
– Back/Ankle
Terell Smith
– Knee
Tysheem Johnson
– Undisclosed
Major Burns
– Knee
Deion Hankins
– Knee
Ameer Speed
– Undisclosed
Josh Blackwell
– Groin
Noah Sewell
– Concussion
Amen Ogbongbemiga
– Shoulder
Ruben Hyppolite II
– Gameday Inactive
Tremaine Edmunds
– Groin
Grady Jarrett
– Knee
Drew Dalman
– Knee
T.J. Edwards
– Hamstring
Dayo Odeyingbo
– Achilles
Darnell Wright
– Elbow
Bill Murray
– Undisclosed
Jonathan Ford
– Gameday Inactive
Luke Newman
– Gameday Inactive
Ricky Stromberg
– Undisclosed
Doug Kramer Jr.
– Undisclosed
Tanoh Kpassagnon
– Gameday Inactive
Braxton Jones
– Gameday Inactive
Kiran Amegadjie
– Gameday Inactive
Jonah Jackson
– Ankle
Ozzy Trapilo
– Gameday Inactive
Theo Benedet
– Quad
Durham Smythe
– Illness
Colston Loveland
– Hip
Cole Kmet
– Groin
Joel Wilson
– Undisclosed
Jordan Murray
– Undisclosed
Luther Burden III
– Concussion
Stephen Carlson
– Gameday Inactive
Dominique Robinson
– Oblique
Chris Williams
– Gameday Inactive
Xavier Carlton
– Undisclosed
Austin Booker
– Knee
Shemar Turner
– Gameday Inactive
Zacch Pickens
– Gameday Inactive
Andrew Billings
– Concussion
Montez Sweat
– Undisclosed
Gervon Dexter Sr.
– Hand
Current Betting Odds
Spread: Bears favored at 3.5
Total (Over/Under): 51.5
Moneyline Odds: 49ers -195 , Bears +164
Recent Matches
49ers
Bears
Date
Vs
Result
Score
12/22/2025
Colts
win
27 :
48
12/14/2025
Titans
win
37
: 24
11/30/2025
Browns
win
8 :
26
11/24/2025
Panthers
win
20
: 9
11/16/2025
Cardinals
win
22 :
41
11/09/2025
Rams
loss
26
: 42
11/02/2025
Giants
win
24 :
34
10/26/2025
Texans
loss
26 :
15
10/19/2025
Falcons
win
20
: 10
10/12/2025
Buccaneers
loss
30 :
19
W - 7
L - 3
Date
Vs
Result
Score
12/20/2025
Packers
win
22
: 16
12/14/2025
Browns
win
31
: 3
12/07/2025
Packers
loss
28 :
21
11/28/2025
Eagles
win
15 :
24
11/23/2025
Steelers
win
31
: 28
11/16/2025
Vikings
win
17 :
19
11/09/2025
Giants
win
24
: 20
11/02/2025
Bengals
win
42 :
47
10/26/2025
Ravens
loss
30 :
16
10/19/2025
Saints
win
26
: 14
W - 8
L - 2
Who Wins: our Prediction
Based on statistical analysis, we see the 49ers at a win probability of 36%, while the Bears have a propability of 64% to win.
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