Panthers host 49ers this Monday at Levi's Stadium. Books show point spread (Panthers ) and total sitting at 49. M/L: Panthers -385, 49ers +307. Numbers reflect current sportsbook listings at the time of writing.
Money Line-350+315
Spread
-7.5
-104
7.0
+100
Over/Under
-102
Matchup Overview
Teams: 49ers vs Panthers
Date: Monday, November 24, 2025
Time: 08:15 pm ET
Venue: Levi's Stadium
Where To Watch 49ers vs Panthers on Monday
The match will be broadcast by ESPN.
Injuries
49ers
Panthers
Ameer Abdullah
– Ribs
Isaiah Prince
– Knee
Tre Tomlinson
– Undisclosed
Carter Bradley
– Undisclosed
Renardo Green
– Neck
Ricky Pearsall
– Knee
Deommodore Lenoir
– Hip
Kurtis Rourke
– Knee
Demarcus Robinson
– Suspended
Malik Mustapha
– Knee
Thomas Morstead
– Back
Mac Jones
– Knee
Brandon Aiyuk
– Personal
Brock Purdy
– Left Shoulder/Toe
Tanner Mordecai
– Undisclosed
Jauan Jennings
– Calf
Jordan Watkins
– Gameday Inactive
Jacob Cowing
– Hamstring
Upton Stout
– Calf
Tre Brown
– Heel
Christian McCaffrey
– Calf
Richie Grant
– Knee
Jason Pinnock
– Heel
Chase Lucas
– Undisclosed
Ji'Ayir Brown
– Hamstring
Darrell Luter Jr.
– Achilles
Jordan James
– Gameday Inactive
Eli Apple
– Gameday Inactive
Isaac Guerendo
– Gameday Inactive
Patrick Taylor Jr.
– Shoulder
Siran Neal
– Head
Dallis Flowers
– Undisclosed
Marques Sigle
– Gameday Inactive
Kyle Juszczyk
– Concussion
Nick Martin
– Gameday Inactive
Chazz Surratt
– Ankle
B.Huff
– Ankle
Tatum Bethune
– Thigh
Corey Kiner
– Undisclosed
Jakob Robinson
– Forearm
Robert Beal Jr.
– Gameday Inactive
Dee Winters
– Knee
Fred Warner
– Ankle
Drew Moss
– Gameday Inactive
Sebastian Valdez
– Gameday Inactive
Tarron Jackson
– Neck
Luke Gifford
– Knee
Curtis Robinson
– Knee
Matt Hennessy
– Neck
Austen Pleasants
– Gameday Inactive
Jake Brendel
– Hamstring
A.Dillard
– Undisclosed
Isaac Alarcon
– Suspension
Colton McKivitz
– Calf
Trent Williams
– Knee
Spencer Burford
– Knee
Connor Colby
– Gameday Inactive
Dominick Puni
– Knee
Ben Bartch
– Undisclosed
Trent Taylor
– Undisclosed
George Kittle
– Achilles
Mason Pline
– Undisclosed
Kevin Givens
– Pectoral
Sam Okuayinonu
– Shoulder
Jordan Elliott
– Ankle
Kalia Davis
– Groin
Yetur Gross-Matos
– Undisclosed
Alfred Collins
– Shoulder
Jonathan Garvin
– Undisclosed
Nick Bosa
– Neck
Mykel Williams
– Knee
CJ West
– Knee
Krys Barnes
– Gameday Inactive
Ja'Tavion Sanders
– Ankle
Mike Jackson
– Ribs
Tetairoa McMillan
– Hamstring
Rico Dowdle
– Quad
Sam Martin
– Undisclosed
Tre'von Moehrig
– Suspension
Jaycee Horn
– Thumb
Bryce Young
– Ankle
Nic Scourton
– Knee
Hunter Renfrow
– Rib
Andy Dalton
– Elbow
Jimmy Horn Jr.
– Shoulder
Xavier Legette
– Hamstring
Jalen Coker
– Quad
Adam Thielen
– Gameday Inactive
Nick Scott
– Groin
Lathan Ransom
– Hand
Jonathon Brooks
– Knee
Chau Smith-Wade
– Chest
Akayleb Evans
– Illness
Chuba Hubbard
– Calf
Corey Thornton
– Leg
Trevin Wallace
– Shoulder
Princely Umanmielen
– Shoulder
Demani Richardson
– Gameday Inactive
Trevian Thomas
– Gameday Inactive
Tyler Mabry
– Undisclosed
Robert Hunt
– Foot
Claudin Cherelus
– Concussion
Cam Jackson
– Gameday Inactive
Christian Rozeboom
– Hip/Hamstring
Jarrett Kingston
– Gameday Inactive
Chandler Zavala
– Knee
Austin Corbett
– Knee
Cade Mays
– Knee
Ja'Tyre Carter
– Undisclosed
Damien Lewis
– Shoulder
Brady Christensen
– Achilles
Taylor Moton
– Lung
Sam Roberts
– Gameday Inactive
Jared Harrison-Hunte
– Gameday Inactive
Yosh Nijman
– Gameday Inactive
Popo Aumavae
– Achilles
Ikem Ekwonu
– Illness
Tommy Tremble
– Undisclosed
David Moore
– Elbow
Mitchell Evans
– Hamstring
James Mitchell
– Gameday Inactive
Brycen Tremayne
– Quadricep
Patrick Jones II
– Ankle
Tershawn Wharton
– Neck
LaBryan Ray
– Undisclosed
A'Shawn Robinson
– Groin
Derrick Brown
– Knee
Jaden Crumedy
– Gameday Inactive
Bobby Brown III
– Hamstring
D.J. Wonnum
– Hip
Shy Tuttle
– Gameday Inactive
Current Betting Odds
Spread: Panthers favored at 7
Total (Over/Under): 49
Moneyline Odds: 49ers -385 , Panthers +307
Recent Matches
49ers
Panthers
Date
Vs
Result
Score
11/16/2025
Cardinals
win
22 :
41
11/09/2025
Rams
loss
26
: 42
11/02/2025
Giants
win
24 :
34
10/26/2025
Texans
loss
26 :
15
10/19/2025
Falcons
win
20
: 10
10/12/2025
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loss
30 :
19
10/02/2025
Rams
win
23 :
26
09/28/2025
Jaguars
loss
21
: 26
09/21/2025
Cardinals
win
16
: 15
09/14/2025
Saints
win
21 :
26
W - 6
L - 4
Date
Vs
Result
Score
11/16/2025
Falcons
win
27 :
30
11/09/2025
Saints
loss
7
: 17
11/02/2025
Packers
win
13 :
16
10/26/2025
Bills
loss
9
: 40
10/19/2025
Jets
win
6 :
13
10/12/2025
Cowboys
win
30
: 27
10/05/2025
Dolphins
win
27
: 24
09/28/2025
Patriots
loss
42 :
13
09/21/2025
Falcons
win
30
: 0
09/14/2025
Cardinals
loss
27 :
22
W - 6
L - 4
Who Wins: our Prediction
Based on statistical analysis, we see the 49ers at a win probability of 24%, while the Panthers have a propability of 76% to win.
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