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    Panthers vs 49ers NFL Week 12 – Match Preview & Live Updates Monday, November 24, 2025

    National Football League
    49ers
    Home
    24/11/2025
    8:15pm
    Panthers
    Away
    Where To Watch Injuries Recent Matches Predicted Winner Futures Statistics

    49ers vs. Panthers: Detailed Breakdown

    Panthers host 49ers this Monday at Levi's Stadium. Books show point spread (Panthers ) and total sitting at 49. M/L: Panthers -385, 49ers +307. Numbers reflect current sportsbook listings at the time of writing.

    Money Line -350 BetMGM +315 Fanatics
    Spread -7.5 -104 FanDuel 7.0 +100 DraftKings
    Over/Under -102 FanDuel DraftKings

    Matchup Overview

    • Teams: 49ers vs Panthers
    • Date: Monday, November 24, 2025
    • Time: 08:15 pm ET
    • Venue: Levi's Stadium

    Where To Watch 49ers vs Panthers on Monday

    The match will be broadcast by ESPN.

    Injuries

    49ers
    Panthers
    Ameer Abdullah
    – Ribs
    Isaiah Prince
    – Knee
    Tre Tomlinson
    – Undisclosed
    Carter Bradley
    – Undisclosed
    Renardo Green
    – Neck
    Ricky Pearsall
    – Knee
    Deommodore Lenoir
    – Hip
    Kurtis Rourke
    – Knee
    Demarcus Robinson
    – Suspended
    Malik Mustapha
    – Knee
    Thomas Morstead
    – Back
    Mac Jones
    – Knee
    Brandon Aiyuk
    – Knee
    Brock Purdy
    – Left Shoulder/Toe
    Tanner Mordecai
    – Undisclosed
    Jauan Jennings
    – Calf
    Jordan Watkins
    – Gameday Inactive
    Jacob Cowing
    – Hamstring
    Upton Stout
    – Calf
    Tre Brown
    – Heel
    Christian McCaffrey
    – Calf
    Richie Grant
    – Knee
    Jason Pinnock
    – Heel
    Chase Lucas
    – Gameday Inactive
    Ji'Ayir Brown
    – Hamstring
    Darrell Luter Jr.
    – Achilles
    Jordan James
    – Gameday Inactive
    Eli Apple
    – Gameday Inactive
    Isaac Guerendo
    – Gameday Inactive
    Patrick Taylor Jr.
    – Shoulder
    Siran Neal
    – Head
    Dallis Flowers
    – Gameday Inactive
    Marques Sigle
    – Gameday Inactive
    Kyle Juszczyk
    – Concussion
    Nick Martin
    – Gameday Inactive
    Chazz Surratt
    – Ankle
    B.Huff
    – Ankle
    Tatum Bethune
    – Thigh
    Corey Kiner
    – Undisclosed
    Jakob Robinson
    – Forearm
    Robert Beal Jr.
    – Gameday Inactive
    Dee Winters
    – Knee
    Fred Warner
    – Ankle
    Drew Moss
    – Gameday Inactive
    Sebastian Valdez
    – Gameday Inactive
    Tarron Jackson
    – Neck
    Luke Gifford
    – Knee
    Curtis Robinson
    – Knee
    Austen Pleasants
    – Gameday Inactive
    Jake Brendel
    – Hamstring
    A.Dillard
    – Undisclosed
    Isaac Alarcon
    – Suspension
    Colton McKivitz
    – Calf
    Trent Williams
    – Knee
    Spencer Burford
    – Knee
    Connor Colby
    – Gameday Inactive
    Dominick Puni
    – Knee
    Ben Bartch
    – Undisclosed
    Trent Taylor
    – Undisclosed
    George Kittle
    – Hamstring
    Mason Pline
    – Undisclosed
    Kevin Givens
    – Pectoral
    Sam Okuayinonu
    – Shoulder
    Jordan Elliott
    – Ankle
    Kalia Davis
    – Groin
    Yetur Gross-Matos
    – Undisclosed
    Alfred Collins
    – Knee
    Nick Bosa
    – Neck
    Mykel Williams
    – Knee
    CJ West
    – Knee
    Krys Barnes
    – Gameday Inactive
    Ja'Tavion Sanders
    – Ankle
    Mike Jackson
    – Ribs
    Tetairoa McMillan
    – Hamstring
    Rico Dowdle
    – Quad
    Sam Martin
    – Undisclosed
    Tre'von Moehrig
    – Suspension
    Jaycee Horn
    – Thumb
    Bryce Young
    – Ankle
    Hunter Renfrow
    – Rib
    Andy Dalton
    – Elbow
    Jimmy Horn Jr.
    – Shoulder
    Xavier Legette
    – Hamstring
    Jalen Coker
    – Quad
    Adam Thielen
    – Gameday Inactive
    Nick Scott
    – Groin
    Lathan Ransom
    – Hand
    Jonathon Brooks
    – Knee
    Chau Smith-Wade
    – Chest
    Akayleb Evans
    – Illness
    Chuba Hubbard
    – Calf
    Corey Thornton
    – Leg
    Trevin Wallace
    – Shoulder
    Princely Umanmielen
    – Shoulder
    Demani Richardson
    – Gameday Inactive
    Trevian Thomas
    – Gameday Inactive
    Tyler Mabry
    – Undisclosed
    Robert Hunt
    – Foot
    Claudin Cherelus
    – Concussion
    Cam Jackson
    – Gameday Inactive
    Christian Rozeboom
    – Hip/Hamstring
    Jarrett Kingston
    – Gameday Inactive
    Chandler Zavala
    – Knee
    Austin Corbett
    – Knee
    Cade Mays
    – Knee
    Ja'Tyre Carter
    – Undisclosed
    Damien Lewis
    – Shoulder
    Brady Christensen
    – Achilles
    Taylor Moton
    – Elbow
    Sam Roberts
    – Gameday Inactive
    Jared Harrison-Hunte
    – Gameday Inactive
    Yosh Nijman
    – Gameday Inactive
    Popo Aumavae
    – Achilles
    Ikem Ekwonu
    – Illness
    Tommy Tremble
    – Undisclosed
    David Moore
    – Elbow
    Mitchell Evans
    – Hamstring
    James Mitchell
    – Gameday Inactive
    Brycen Tremayne
    – Quadricep
    Patrick Jones II
    – Ankle
    Tershawn Wharton
    – Hamstring
    LaBryan Ray
    – Undisclosed
    A'Shawn Robinson
    – Groin
    Derrick Brown
    – Knee
    Jaden Crumedy
    – Gameday Inactive
    Bobby Brown III
    – Hamstring
    D.J. Wonnum
    – Hip
    Shy Tuttle
    – Gameday Inactive

    Current Betting Odds

    • Spread: Panthers favored at 7
    • Total (Over/Under): 49
    • Moneyline Odds: 49ers -385 , Panthers +307

    Recent Matches

    49ers
    Panthers
    Date Vs Result Score
    11/16/2025 Cardinals win 22 : 41
    11/09/2025 Rams loss 26 : 42
    11/02/2025 Giants win 24 : 34
    10/26/2025 Texans loss 26 : 15
    10/19/2025 Falcons win 20 : 10
    10/12/2025 Buccaneers loss 30 : 19
    10/02/2025 Rams win 23 : 26
    09/28/2025 Jaguars loss 21 : 26
    09/21/2025 Cardinals win 16 : 15
    09/14/2025 Saints win 21 : 26
    W - 6
    L - 4
    Date Vs Result Score
    11/16/2025 Falcons win 27 : 30
    11/09/2025 Saints loss 7 : 17
    11/02/2025 Packers win 13 : 16
    10/26/2025 Bills loss 9 : 40
    10/19/2025 Jets win 6 : 13
    10/12/2025 Cowboys win 30 : 27
    10/05/2025 Dolphins win 27 : 24
    09/28/2025 Patriots loss 42 : 13
    09/21/2025 Falcons win 30 : 0
    09/14/2025 Cardinals loss 27 : 22
    W - 6
    L - 4

    Who Wins: our Prediction

    Based on statistical analysis, we see the 49ers at a win probability of 24%, while the Panthers have a propability of 76% to win.

    Find the best Futures for 49ers vs Panthers

    Statistics

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