For Patriots at Panthers on Sunday, September 28, 2025, sportsbooks post Point Spread Panthers with O/U 42.5 ML: Panthers -245, Patriots +203 appears on boards. Kickoff is 1:00 pm ET. Lines are live at books.
Money Line-240+220
Spread
-5.5
-110
5.5
-108
Over/Under
-105
Matchup Overview
Teams: Patriots vs Panthers
Date: Sunday, September 28, 2025
Time: 01:00 pm ET
Venue: Gillette Stadium
Where To Watch Patriots vs Panthers on Sunday
Watch the full match on FOX.
Injuries
Patriots
Panthers
Yasir Durant
– Undisclosed
Christian Gonzalez
– Concussion
Ja'Lynn Polk
– Shoulder
Harold Landry III
– Foot
DeMario Douglas
– Hamstring
Antonio Gibson
– Knee
Jabrill Peppers
– Quadricep
Carlton Davis III
– Achilles
Stefon Diggs
– Knee
Kayshon Boutte
– Shoulder
Drake Maye
– Right Shoulder
Mack Hollins
– Hand
Robert Spillane
– Hand
Marte Mapu
– Neck
Kobee Minor
– Gameday Inactive
Jaylinn Hawkins
– Hamstring
Marcus Epps
– Shoulder
Kyle Dugger
– Knee
Marcus Jones
– Elbow
Terrell Jennings
– Head
Marcellas Dial Jr.
– ACL
Alex Austin
– Undisclosed
Jeremiah Webb
– Undisclosed
Craig Woodson
– Ankle
TreVeyon Henderson
– Shoulder
Anfernee Jennings
– Knee
Lan Larison
– Undisclosed
Rhamondre Stevenson
– Toe
Brenden Schooler
– Ankle
Bradyn Swinson
– Gameday Inactive
K'Lavon Chaisson
– Knee
Brock Lampe
– Undisclosed
Jahlani Tavai
– Calf
Jack Gibbens
– Hamstring
Marcus Bryant
– Gameday Inactive
Christian Elliss
– Shoulder
Jared Wilson
– Thigh
Vederian Lowe
– Undisclosed
Layden Robinson
– Undisclosed
Garrett Bradbury
– Illness
Will Campbell
– Ankle
Isaiah Iton
– Hip
Caedan Wallace
– Gameday Inactive
Mike Onwenu
– Shoulder
Demontrey Jacobs
– Gameday Inactive
Morgan Moses
– Knee
Austin Hooper
– Undisclosed
CJ Dippre
– Illness
Kendrick Bourne
– Rib
Hunter Henry
– Knee
Efton Chism III
– Knee
Jack Westover
– Hamstring
Christian Barmore
– Personal
Elijah Ponder
– Gameday Inactive
Joshua Farmer
– Ankle
Jaquelin Roy
– Undisclosed
Khyiris Tonga
– Knee
M.Williams
– Ankle
Keion White
– Illness
Krys Barnes
– Gameday Inactive
Ja'Tavion Sanders
– Ankle
Mike Jackson
– Ribs
Tetairoa McMillan
– Hamstring
Rico Dowdle
– Quad
Sam Martin
– Undisclosed
Tre'von Moehrig
– Suspension
Jaycee Horn
– Thumb
Bryce Young
– Ankle
Hunter Renfrow
– Rib
Andy Dalton
– Elbow
Jimmy Horn Jr.
– Shoulder
Xavier Legette
– Hamstring
Jalen Coker
– Quad
Adam Thielen
– Gameday Inactive
Nick Scott
– Groin
Lathan Ransom
– Hand
Jonathon Brooks
– Knee
Chau Smith-Wade
– Chest
Akayleb Evans
– Illness
Chuba Hubbard
– Calf
Corey Thornton
– Leg
Trevin Wallace
– Shoulder
Princely Umanmielen
– Shoulder
Demani Richardson
– Gameday Inactive
Trevian Thomas
– Gameday Inactive
Tyler Mabry
– Undisclosed
Robert Hunt
– Foot
Claudin Cherelus
– Concussion
Cam Jackson
– Gameday Inactive
Christian Rozeboom
– Hip/Hamstring
Jarrett Kingston
– Gameday Inactive
Chandler Zavala
– Knee
Austin Corbett
– Knee
Cade Mays
– Knee
Ja'Tyre Carter
– Undisclosed
Damien Lewis
– Shoulder
Brady Christensen
– Achilles
Taylor Moton
– Elbow
Sam Roberts
– Gameday Inactive
Jared Harrison-Hunte
– Gameday Inactive
Yosh Nijman
– Gameday Inactive
Popo Aumavae
– Achilles
Ikem Ekwonu
– Illness
Tommy Tremble
– Undisclosed
David Moore
– Elbow
Mitchell Evans
– Hamstring
James Mitchell
– Gameday Inactive
Brycen Tremayne
– Quadricep
Patrick Jones II
– Ankle
Tershawn Wharton
– Hamstring
LaBryan Ray
– Undisclosed
A'Shawn Robinson
– Groin
Derrick Brown
– Knee
Jaden Crumedy
– Gameday Inactive
Bobby Brown III
– Hamstring
D.J. Wonnum
– Hip
Shy Tuttle
– Gameday Inactive
Current Betting Odds
Spread: Panthers favored at 5.5
Total (Over/Under): 42.5
Moneyline Odds: Patriots -245 , Panthers +203
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Panthers
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W - 4
L - 6
Date
Vs
Result
Score
09/21/2025
Falcons
win
30
: 0
09/14/2025
Cardinals
loss
27 :
22
09/07/2025
Jaguars
loss
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loss
10
: 19
08/16/2025
Texans
loss
20 :
3
08/08/2025
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loss
10
: 30
01/05/2025
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win
38 :
44
12/29/2024
Buccaneers
loss
48 :
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Cardinals
win
36
: 30
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Cowboys
loss
14
: 30
W - 3
L - 7
Who Wins: our Prediction
Based on statistical analysis, we see the Patriots at a win probability of 32%, while the Panthers have a propability of 68% to win.
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