For Steelers at Bills on Sunday, November 30, 2025, sportsbooks post Point Spread Steelers with O/U 44.5 ML: Bills +143, Steelers -170 appears on boards. Kickoff is 4:25 pm ET. Lines are live at books.
Money Line+146-165
Spread
3.0
-105
-3.0
-110
Over/Under
-108
Matchup Overview
Teams: Steelers vs Bills
Date: Sunday, November 30, 2025
Time: 04:25 pm ET
Venue: Acrisure Stadium
Where To Watch Steelers vs Bills on Sunday
Watch the full match on CBS.
Injuries
Steelers
Bills
Donald Parham Jr.
– Achilles
Jacob Slade
– Undisclosed
DK Metcalf
– Ankle
Jalen Ramsey
– Hamstring
Cameron Johnston
– Leg
Patrick Queen
– Hip
Aaron Rodgers
– Left Wrist
Roman Wilson
– Gameday Inactive
Brandon Johnson
– Undisclosed
Scotty Miller
– Gameday Inactive
Ben Skowronek
– Illness
Skylar Thompson
– Hamstring
Will Howard
– Hand
Calvin Austin III
– Abdomen
Kaleb Johnson
– Gameday Inactive
Chuck Clark
– Gameday Inactive
D.Slay Jr.
– Gameday Inactive
Joey Porter Jr.
– Hamstring
DeShon Elliott
– Personal
Brandin Echols
– Ankle
Cory Trice Jr.
– Hamstring
Miles Killebrew
– Knee
Sebastian Castro
– Gameday Inactive
Jaylen Warren
– Knee
Donte Kent
– Ankle/Knee
Devin Harper
– Undisclosed
James Pierre
– Concussion
Christian Kuntz
– Chest
Malik Harrison
– Knee
Nick Herbig
– Hamstring
Zach Frazier
– Calf
Cole Holcomb
– Illness
Alex Highsmith
– Ankle
Max Scharping
– Gameday Inactive
Calvin Anderson
– Illness
Domenique Davis
– Undisclosed
Gareth Warren
– Concussion
Esezi Otomewo
– Gameday Inactive
Isaac Seumalo
– Pectoral
Troy Fautanu
– Personal
Broderick Jones
– Groin
Yahya Black
– Shoulder
Darnell Washington
– Foot
Jonnu Smith
– Knee
Connor Heyward
– Knee
Ke'Shawn Williams
– Concussion
Pat Freiermuth
– Quadricep
T.J. Watt
– Hip
Logan Lee
– Gameday Inactive
Isaiahh Loudermilk
– Ankle
Dean Lowry
– Knee
Keeanu Benton
– Upper Body
Daniel Ekuale
– Knee
Cameron Heyward
– Knee
DeMarvin Leal
– Gameday Inactive
Derrick Harmon
– Knee
Hayden Harris
– Hamstring
Keon Coleman
– Groin
Curtis Samuel
– Elbow
Tyler Bass
– Left Hip/Groin
Damar Hamlin
– Pectoral
James Cook
– Hamstring
Joshua Palmer
– Ankle
Taron Johnson
– Groin
Terrel Bernard
– Hamstring
Taylor Rapp
– Nose
Khalil Shakir
– Ankle
Mitchell Trubisky
– Illness
Jalen Virgil
– Undisclosed
Mike White
– Gameday Inactive
Josh Allen
– Right Elbow
Elijah Moore
– Personal
Darrynton Evans
– Undisclosed
Ray Davis
– Illness
Cole Bishop
– Cramping
Ty Johnson
– Ankle
Tre'Davious White
– Leg
Brandon Codrington
– Knee
Wande Owens
– Undisclosed
Maxwell Hairston
– Knee
Te'Cory Couch
– Hamstring
Jordan Hancock
– Shoulder
Cam Lewis
– Shoulder
Reggie Gilliam
– Knee
Dorian Williams
– Knee
Dorian Strong
– Neck
Shaq Thompson
– Hamstring/Hand
Ja'Marcus Ingram
– Gameday Inactive
Christian Benford
– Groin
Greg Rousseau
– Knee
Kendrick Green
– Gameday Inactive
Baylon Spector
– Undisclosed
Michael Hoecht
– Suspension
A.J. Epenesa
– Pectoral
Matt Milano
– Pectoral
Sedrick Van Pran-Granger
– Undisclosed
Connor McGovern
– Hamstring
Tylan Grable
– Undisclosed
Reid Ferguson
– Neck
Alec Anderson
– Knee
Marcus Harris
– Knee
Dion Dawkins
– Thumb
Chase Lundt
– Gameday Inactive
Spencer Brown
– Undisclosed
Tyrell Shavers
– Knee
Kaden Prather
– Hamstring
Jackson Hawes
– Ankle
Dalton Kincaid
– Hamstring
Dawson Knox
– Hip
DeWayne Carter
– Achilles
Ed Oliver
– Bicep
DaQuan Jones
– Calf
Landon Jackson
– Gameday Inactive
Deone Walker
– Ilness
Joey Bosa
– Hamstring
T.J. Sanders
– Knee
Larry Ogunjobi
– Gameday Inactive
Current Betting Odds
Spread: Steelers favored at 3
Total (Over/Under): 44.5
Moneyline Odds: Steelers +143 , Bills -170
Recent Matches
Steelers
Bills
Date
Vs
Result
Score
11/23/2025
Bears
loss
31 :
28
11/16/2025
Bengals
win
34
: 12
11/09/2025
Chargers
loss
25 :
10
11/02/2025
Colts
win
27
: 20
10/26/2025
Packers
loss
25
: 35
10/16/2025
Bengals
loss
33 :
31
10/12/2025
Browns
win
23
: 9
09/28/2025
Vikings
win
24
: 21
09/21/2025
Patriots
win
14 :
21
09/14/2025
Seahawks
loss
17
: 31
W - 5
L - 5
Date
Vs
Result
Score
11/20/2025
Texans
loss
23 :
19
11/16/2025
Buccaneers
win
44
: 32
11/09/2025
Dolphins
loss
30 :
13
11/02/2025
Chiefs
win
28
: 21
10/26/2025
Panthers
win
9 :
40
10/13/2025
Falcons
loss
24 :
14
10/05/2025
Patriots
loss
20
: 23
09/28/2025
Saints
win
31
: 19
09/18/2025
Dolphins
win
31
: 21
09/14/2025
Jets
win
10 :
30
W - 6
L - 4
Who Wins: our Prediction
Based on statistical analysis, we see the Steelers at a win probability of 60%, while the Bills have a propability of 40% to win.
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