The slate moves into Thursday with Texans at Bills. Current point spread: Texans ; O/U: 44.5 ML: Bills +220, Texans -268. Books list full pricing ahead of kickoff at 8:15 pm ET.
Money Line+225-245
Spread
5.0
-105
-5.5
-105
Over/Under
-105
Matchup Overview
Teams: Texans vs Bills
Date: Thursday, November 20, 2025
Time: 08:15 pm ET
Venue: NRG Stadium
Where To Watch Texans vs Bills on Thursday
Watch the full match on AMZN.
Injuries
Texans
Bills
Azeez Al-Shaair
– Knee/Illness
Tank Dell
– Knee
Kamari Lassiter
– Knee
Jalen Pitre
– Rib
C.J. Stroud
– Concussion
Brevin Jordan
– Knee
Davis Mills
– Elbow
T.Smith
– Personal
Nico Collins
– Concussion
Christian Kirk
– Hamstring
Ka'imi Fairbairn
– Right Quad
Braxton Berrios
– Chest
Graham Mertz
– Gameday Inactive
Jimmie Ward
– Foot
Nick Chubb
– Foot
Jawhar Jordan
– Ankle
C.Gardner-Johnson
– Knee
Derek Stingley Jr.
– Abdomen
Myles Bryant
– Ankle
Woody Marks
– Calf
Joe Mixon
– Foot
M.J. Stewart
– Knee
Jaylin Smith
– Hamstring
Dameon Pierce
– Quad
Nick Niemann
– Pectoral
Jaylen Reed
– Undisclosed
Jake Hansen
– Elbow
Alijah Huzzie
– Knee
Austin Brinkman
– Knee
Damon Arnette
– Ankle
Jakob Johnson
– Hamstring
British Brooks
– Gameday Inactive
E.J. Speed
– Knee
K.C. Ossai
– Undisclosed
Christian Harris
– Gameday Inactive
Solomon Byrd
– Gameday Inactive
Will Anderson Jr.
– Quad
Darrell Taylor
– Hip
Jamal Hill
– Hamstring
Blake Fisher
– Ankle
Kyonte Hamilton
– Ankle
Jake Andrews
– Foot
Marlon Davidson
– Undisclosed
Ed Ingram
– Abdomen
Tytus Howard
– Ankle/Knee
Tommy Togiai
– Gameday Inactive
Cam Robinson
– Illness
Laken Tomlinson
– Gameday Inactive
Austin Deculus
– Gameday Inactive
Trent Brown
– Knee
Aireontae Ersery
– Thumb
Irv Smith Jr.
– Ankle
Justin Watson
– Undisclosed
Dalton Schultz
– Knee/Shoulder
Cade Stover
– Foot
Johnny Johnson III
– Undisclosed
Xavier Johnson
– Undisclosed
Sheldon Rankins
– Knee
Folorunso Fatukasi
– Undisclosed
Dylan Horton
– Knee
Kurt Hinish
– Shoulder
Derek Barnett
– Undisclosed
Denico Autry
– Knee
Mario Edwards Jr.
– Pectoral
Tim Settle Jr.
– Foot
Hayden Harris
– Hamstring
Keon Coleman
– Groin
Curtis Samuel
– Elbow
Tyler Bass
– Left Hip/Groin
Damar Hamlin
– Pectoral
James Cook
– Hamstring
Joshua Palmer
– Ankle
Taron Johnson
– Groin
Terrel Bernard
– Hamstring
Taylor Rapp
– Nose
Khalil Shakir
– Ankle
Mitchell Trubisky
– Illness
Jalen Virgil
– Undisclosed
Mike White
– Gameday Inactive
Josh Allen
– Right Elbow
Elijah Moore
– Personal
Darrynton Evans
– Undisclosed
Ray Davis
– Illness
Cole Bishop
– Cramping
Ty Johnson
– Ankle
Tre'Davious White
– Leg
Brandon Codrington
– Knee
Wande Owens
– Undisclosed
Maxwell Hairston
– Knee
Te'Cory Couch
– Hamstring
Jordan Hancock
– Shoulder
Cam Lewis
– Shoulder
Reggie Gilliam
– Knee
Dorian Williams
– Knee
Dorian Strong
– Neck
Shaq Thompson
– Hamstring/Hand
Ja'Marcus Ingram
– Gameday Inactive
Christian Benford
– Groin
Greg Rousseau
– Knee
Kendrick Green
– Gameday Inactive
Baylon Spector
– Undisclosed
Michael Hoecht
– Suspension
A.J. Epenesa
– Pectoral
Matt Milano
– Pectoral
Sedrick Van Pran-Granger
– Undisclosed
Connor McGovern
– Hamstring
Tylan Grable
– Undisclosed
Reid Ferguson
– Neck
Alec Anderson
– Knee
Marcus Harris
– Knee
Dion Dawkins
– Thumb
Chase Lundt
– Gameday Inactive
Spencer Brown
– Undisclosed
Tyrell Shavers
– Knee
Kaden Prather
– Hamstring
Jackson Hawes
– Ankle
Dalton Kincaid
– Hamstring
Dawson Knox
– Hip
DeWayne Carter
– Achilles
Ed Oliver
– Bicep
DaQuan Jones
– Calf
Landon Jackson
– Gameday Inactive
Deone Walker
– Ilness
Joey Bosa
– Hamstring
T.J. Sanders
– Knee
Larry Ogunjobi
– Gameday Inactive
Current Betting Odds
Spread: Texans favored at 5.5
Total (Over/Under): 44.5
Moneyline Odds: Texans +220 , Bills -268
Recent Matches
Texans
Bills
Date
Vs
Result
Score
11/16/2025
Titans
win
13 :
16
11/09/2025
Jaguars
win
36
: 29
11/02/2025
Broncos
loss
15
: 18
10/26/2025
49ers
win
26
: 15
10/20/2025
Seahawks
loss
27 :
19
10/05/2025
Ravens
win
10 :
44
09/28/2025
Titans
win
26
: 0
09/21/2025
Jaguars
loss
17 :
10
09/15/2025
Buccaneers
loss
19
: 20
09/07/2025
Rams
loss
14 :
9
W - 5
L - 5
Date
Vs
Result
Score
11/16/2025
Buccaneers
win
44
: 32
11/09/2025
Dolphins
loss
30 :
13
11/02/2025
Chiefs
win
28
: 21
10/26/2025
Panthers
win
9 :
40
10/13/2025
Falcons
loss
24 :
14
10/05/2025
Patriots
loss
20
: 23
09/28/2025
Saints
win
31
: 19
09/18/2025
Dolphins
win
31
: 21
09/14/2025
Jets
win
10 :
30
09/07/2025
Ravens
win
41
: 40
W - 7
L - 3
Who Wins: our Prediction
Based on statistical analysis, we see the Texans at a win probability of 70%, while the Bills have a propability of 30% to win.
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