On Sunday, October 26, 2025, Panthers face Bills. The Point Spread is Panthers , while the Total is 47.5 M/L: Bills +317, Panthers -407 is available. Sportsbetting sites have full lines listed.
Money Line+330-395
Spread
7.0
-105
-7.5
-102
Over/Under
-110
Matchup Overview
Teams: Panthers vs Bills
Date: Sunday, October 26, 2025
Time: 01:00 pm ET
Venue: Bank of America Stadium
Where To Watch Panthers vs Bills on Sunday
The match will be broadcast by FOX.
Injuries
Panthers
Bills
Krys Barnes
– Gameday Inactive
Ja'Tavion Sanders
– Ankle
Mike Jackson
– Ribs
Tetairoa McMillan
– Hamstring
Rico Dowdle
– Quad
Sam Martin
– Undisclosed
Tre'von Moehrig
– Suspension
Jaycee Horn
– Thumb
Bryce Young
– Ankle
Nic Scourton
– Knee
Hunter Renfrow
– Rib
Andy Dalton
– Elbow
Jimmy Horn Jr.
– Shoulder
Xavier Legette
– Hamstring
Jalen Coker
– Quad
Adam Thielen
– Gameday Inactive
Nick Scott
– Groin
Lathan Ransom
– Hand
Jonathon Brooks
– Knee
Chau Smith-Wade
– Chest
Akayleb Evans
– Illness
Chuba Hubbard
– Calf
Corey Thornton
– Leg
Trevin Wallace
– Shoulder
Princely Umanmielen
– Shoulder
Demani Richardson
– Gameday Inactive
Trevian Thomas
– Gameday Inactive
Tyler Mabry
– Undisclosed
Robert Hunt
– Foot
Claudin Cherelus
– Concussion
Cam Jackson
– Gameday Inactive
Christian Rozeboom
– Hip/Hamstring
Jarrett Kingston
– Gameday Inactive
Chandler Zavala
– Knee
Austin Corbett
– Knee
Cade Mays
– Knee
Ja'Tyre Carter
– Undisclosed
Damien Lewis
– Shoulder
Brady Christensen
– Achilles
Taylor Moton
– Lung
Sam Roberts
– Gameday Inactive
Jared Harrison-Hunte
– Gameday Inactive
Yosh Nijman
– Gameday Inactive
Popo Aumavae
– Achilles
Ikem Ekwonu
– Illness
Tommy Tremble
– Undisclosed
David Moore
– Elbow
Mitchell Evans
– Hamstring
James Mitchell
– Gameday Inactive
Brycen Tremayne
– Quadricep
Patrick Jones II
– Ankle
Tershawn Wharton
– Neck
LaBryan Ray
– Undisclosed
A'Shawn Robinson
– Groin
Derrick Brown
– Knee
Jaden Crumedy
– Gameday Inactive
Bobby Brown III
– Hamstring
D.J. Wonnum
– Hip
Shy Tuttle
– Gameday Inactive
Hayden Harris
– Hamstring
Keon Coleman
– Groin
Curtis Samuel
– Elbow
Tyler Bass
– Left Hip/Groin
Damar Hamlin
– Pectoral
James Cook
– Hamstring
Joshua Palmer
– Ankle
Taron Johnson
– Groin
Terrel Bernard
– Hamstring
Taylor Rapp
– Nose
Khalil Shakir
– Ankle
Mitchell Trubisky
– Illness
Jalen Virgil
– Undisclosed
Mike White
– Gameday Inactive
Josh Allen
– Right Elbow
Elijah Moore
– Personal
Darrynton Evans
– Undisclosed
Ray Davis
– Illness
Cole Bishop
– Cramping
Daequan Hardy
– Undisclosed
Ty Johnson
– Ankle
Tre'Davious White
– Leg
Darrick Forrest
– Undisclosed
Brandon Codrington
– Knee
Wande Owens
– Undisclosed
Maxwell Hairston
– Knee
Te'Cory Couch
– Hamstring
Jordan Hancock
– Shoulder
Cam Lewis
– Shoulder
Reggie Gilliam
– Knee
Dorian Williams
– Knee
Dorian Strong
– Neck
Shaq Thompson
– Hamstring/Hand
Ja'Marcus Ingram
– Gameday Inactive
Christian Benford
– Groin
Greg Rousseau
– Knee
Kendrick Green
– Undisclosed
Baylon Spector
– Undisclosed
Michael Hoecht
– Suspension
A.J. Epenesa
– Pectoral
Matt Milano
– Pectoral
Sedrick Van Pran-Granger
– Undisclosed
Connor McGovern
– Hamstring
Tylan Grable
– Undisclosed
Reid Ferguson
– Neck
Alec Anderson
– Knee
Marcus Harris
– Knee
Dion Dawkins
– Thumb
Chase Lundt
– Gameday Inactive
Spencer Brown
– Undisclosed
Tyrell Shavers
– Knee
Kaden Prather
– Hamstring
Jackson Hawes
– Ankle
Dalton Kincaid
– Hamstring
Dawson Knox
– Hip
DeWayne Carter
– Achilles
Ed Oliver
– Bicep
DaQuan Jones
– Calf
Landon Jackson
– Gameday Inactive
Deone Walker
– Ilness
Joey Bosa
– Hamstring
T.J. Sanders
– Knee
Larry Ogunjobi
– Gameday Inactive
Current Betting Odds
Spread: Panthers favored at 7
Total (Over/Under): 47.5
Moneyline Odds: Panthers +317 , Bills -407
Recent Matches
Panthers
Bills
Date
Vs
Result
Score
10/19/2025
Jets
win
6 :
13
10/12/2025
Cowboys
win
30
: 27
10/05/2025
Dolphins
win
27
: 24
09/28/2025
Patriots
loss
42 :
13
09/21/2025
Falcons
win
30
: 0
09/14/2025
Cardinals
loss
27 :
22
09/07/2025
Jaguars
loss
26 :
10
08/21/2025
Steelers
loss
10
: 19
08/16/2025
Texans
loss
20 :
3
08/08/2025
Browns
loss
10
: 30
W - 4
L - 6
Date
Vs
Result
Score
10/13/2025
Falcons
loss
24 :
14
10/05/2025
Patriots
loss
20
: 23
09/28/2025
Saints
win
31
: 19
09/18/2025
Dolphins
win
31
: 21
09/14/2025
Jets
win
10 :
30
09/07/2025
Ravens
win
41
: 40
08/23/2025
Buccaneers
win
19 :
23
08/17/2025
Bears
loss
38 :
0
08/09/2025
Giants
loss
25
: 34
01/26/2025
Chiefs
loss
32 :
29
W - 5
L - 5
Who Wins: our Prediction
Based on statistical analysis, we see the Panthers at a win probability of 77%, while the Bills have a propability of 23% to win.
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