49ers and Cardinals meet Sunday, September 21, 2025, 4:25 pm ET. Vegas lists Point Spread Cardinals ; O/U 44.5 ML: Cardinals -123, 49ers +103 is posted. Pricing is consistent across leading sportsbooks.
Money Line-122+105
Spread
-1.5
-108
1.5
-110
Over/Under
-108
Matchup Overview
Teams: 49ers vs Cardinals
Date: Sunday, September 21, 2025
Time: 04:25 pm ET
Venue: Levi's Stadium
Where To Watch 49ers vs Cardinals on Sunday
The match will be broadcast by FOX.
Injuries
49ers
Cardinals
Ameer Abdullah
– Ribs
Isaiah Prince
– Knee
Tre Tomlinson
– Undisclosed
Carter Bradley
– Undisclosed
Renardo Green
– Neck
Ricky Pearsall
– Knee
Deommodore Lenoir
– Hip
Kurtis Rourke
– Knee
Demarcus Robinson
– Suspended
Malik Mustapha
– Knee
Thomas Morstead
– Back
Mac Jones
– Knee
Brandon Aiyuk
– Personal
Brock Purdy
– Left Shoulder/Toe
Tanner Mordecai
– Undisclosed
Jauan Jennings
– Calf
Jordan Watkins
– Gameday Inactive
Jacob Cowing
– Hamstring
Upton Stout
– Calf
Tre Brown
– Heel
Christian McCaffrey
– Calf
Richie Grant
– Knee
Jason Pinnock
– Heel
Chase Lucas
– Undisclosed
Ji'Ayir Brown
– Hamstring
Darrell Luter Jr.
– Achilles
Jordan James
– Gameday Inactive
Eli Apple
– Gameday Inactive
Isaac Guerendo
– Gameday Inactive
Patrick Taylor Jr.
– Shoulder
Siran Neal
– Head
Dallis Flowers
– Undisclosed
Marques Sigle
– Gameday Inactive
Kyle Juszczyk
– Concussion
Nick Martin
– Gameday Inactive
Chazz Surratt
– Ankle
B.Huff
– Ankle
Tatum Bethune
– Thigh
Corey Kiner
– Undisclosed
Jakob Robinson
– Forearm
Robert Beal Jr.
– Gameday Inactive
Dee Winters
– Knee
Fred Warner
– Ankle
Drew Moss
– Gameday Inactive
Sebastian Valdez
– Gameday Inactive
Tarron Jackson
– Neck
Luke Gifford
– Knee
Curtis Robinson
– Knee
Matt Hennessy
– Neck
Austen Pleasants
– Gameday Inactive
Jake Brendel
– Hamstring
A.Dillard
– Undisclosed
Isaac Alarcon
– Suspension
Colton McKivitz
– Calf
Trent Williams
– Knee
Spencer Burford
– Knee
Connor Colby
– Gameday Inactive
Dominick Puni
– Knee
Ben Bartch
– Undisclosed
Trent Taylor
– Undisclosed
George Kittle
– Achilles
Mason Pline
– Undisclosed
Kevin Givens
– Pectoral
Sam Okuayinonu
– Shoulder
Jordan Elliott
– Ankle
Kalia Davis
– Groin
Yetur Gross-Matos
– Undisclosed
Alfred Collins
– Shoulder
Jonathan Garvin
– Undisclosed
Nick Bosa
– Neck
Mykel Williams
– Knee
CJ West
– Knee
Will Johnson
– Groin
Kyler Murray
– Illness
Mack Wilson Sr.
– Ankle
Budda Baker
– Hamstring
Greg Dortch
– Collarbone
Baron Browning
– Concussion
James Conner
– Ankle
BJ Ojulari
– Undisclosed
J.Sweat
– Knee
Blake Gillikin
– Back
Kei'Trel Clark
– Gameday Inactive
Michael Wilson
– Foot
Quez Watkins
– Undisclosed
Max Melton
– Hamstring
Zay Jones
– Knee
Marvin Harrison Jr.
– Concussion
DeeJay Dallas
– Gameday Inactive
Garrett Williams
– Achilles
Sean Murphy-Bunting
– Knee
Starling Thomas V
– Knee
Zaven Collins
– Hand
Jammie Robinson
– Gameday Inactive
Akeem Davis-Gaither
– Elbow
Elijah Jones
– Gameday Inactive
Denzel Burke
– Knee
Darren Hall
– Ankle
Emari Demercado
– Ankle
Joey Blount
– Neck
Trey Benson
– Knee
Jalen Thompson
– Hamstring
Bam Knight
– Gameday Inactive
Kitan Crawford
– Ankle
Jaylon Jones
– Hamstring
Dadrion Taylor-Demerson
– Ankle
Owen Pappoe
– Quadricep
Cody Simon
– Concussion
J.J. Russell
– Concussion
Xavier Thomas
– Gameday Inactive
Dante Stills
– Heel
Darius Robinson
– Chest
Hayden Conner
– Gameday Inactive
Jon Gaines II
– Thumb
Evan Brown
– Hamstring
Jeremiah Byers
– Gameday Inactive
Kelvin Beachum
– Knee
Valentin Senn
– Neck
Paris Johnson Jr.
– Knee
Hjalte Froholdt
– Elbow
Jonah Williams
– Foot
Christian Jones
– Knee
Josh Fryar
– Gameday Inactive
PJ Mustipher
– Foot
Simi Fehoko
– Concussion
Travis Vokolek
– Gameday Inactive
Andre Baccellia
– Arm
Elijah Higgins
– Illness
Trishton Jackson
– Thumb
Tip Reiman
– Ankle
Xavier Weaver
– Gameday Inactive
L.J. Collier
– Knee
Bilal Nichols
– Undisclosed
Dalvin Tomlinson
– Knee
Elijah Simmons
– Gameday Inactive
Walter Nolen III
– Calf
Justin Jones
– Knee
Current Betting Odds
Spread: Cardinals favored at 1.5
Total (Over/Under): 44.5
Moneyline Odds: 49ers -123 , Cardinals +103
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Cardinals
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W - 5
L - 5
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Panthers
win
27
: 22
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win
13 :
20
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win
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: 10
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win
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: 17
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win
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: 24
12/28/2024
Rams
loss
13 :
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12/22/2024
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loss
36 :
30
12/15/2024
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win
30
: 17
12/08/2024
Seahawks
loss
18
: 30
W - 6
L - 4
Who Wins: our Prediction
Based on statistical analysis, we see the 49ers at a win probability of 47%, while the Cardinals have a propability of 53% to win.
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