promoguy.us
PromoGuy logo
Discord
Twitter
Youtube
Facebook
Mail
Reddit

    49ers vs Cardinals NFL Week 3 – Match Preview & Live Updates Sunday, September 21, 2025

    National Football League
    49ers
    Home
    21/09/2025
    4:25pm
    Cardinals
    Away
    Where To Watch Injuries Recent Matches Predicted Winner Futures Statistics

    49ers vs. Cardinals: Detailed Breakdown

    49ers and Cardinals meet Sunday, September 21, 2025, 4:25 pm ET. Vegas lists Point Spread Cardinals ; O/U 44.5 ML: Cardinals -123, 49ers +103 is posted. Pricing is consistent across leading sportsbooks.

    Money Line -122 FanDuel +105 DraftKings
    Spread -1.5 -108 DraftKings 1.5 -110 BetMGM
    Over/Under -108 DraftKings DraftKings

    Matchup Overview

    • Teams: 49ers vs Cardinals
    • Date: Sunday, September 21, 2025
    • Time: 04:25 pm ET
    • Venue: Levi's Stadium

    Where To Watch 49ers vs Cardinals on Sunday

    The match will be broadcast by FOX.

    Injuries

    49ers
    Cardinals
    Ameer Abdullah
    – Ribs
    Isaiah Prince
    – Knee
    Tre Tomlinson
    – Undisclosed
    Carter Bradley
    – Undisclosed
    Renardo Green
    – Neck
    Ricky Pearsall
    – Knee
    Deommodore Lenoir
    – Hip
    Kurtis Rourke
    – Knee
    Demarcus Robinson
    – Suspended
    Malik Mustapha
    – Knee
    Thomas Morstead
    – Back
    Mac Jones
    – Knee
    Brandon Aiyuk
    – Knee
    Brock Purdy
    – Left Shoulder/Toe
    Tanner Mordecai
    – Undisclosed
    Jauan Jennings
    – Calf
    Jordan Watkins
    – Gameday Inactive
    Jacob Cowing
    – Hamstring
    Upton Stout
    – Calf
    Tre Brown
    – Heel
    Christian McCaffrey
    – Calf
    Richie Grant
    – Knee
    Jason Pinnock
    – Heel
    Chase Lucas
    – Gameday Inactive
    Ji'Ayir Brown
    – Hamstring
    Darrell Luter Jr.
    – Achilles
    Jordan James
    – Gameday Inactive
    Eli Apple
    – Gameday Inactive
    Isaac Guerendo
    – Gameday Inactive
    Patrick Taylor Jr.
    – Shoulder
    Siran Neal
    – Head
    Dallis Flowers
    – Gameday Inactive
    Marques Sigle
    – Gameday Inactive
    Kyle Juszczyk
    – Concussion
    Nick Martin
    – Gameday Inactive
    Chazz Surratt
    – Ankle
    B.Huff
    – Ankle
    Tatum Bethune
    – Thigh
    Corey Kiner
    – Undisclosed
    Jakob Robinson
    – Forearm
    Robert Beal Jr.
    – Gameday Inactive
    Dee Winters
    – Knee
    Fred Warner
    – Ankle
    Drew Moss
    – Gameday Inactive
    Sebastian Valdez
    – Gameday Inactive
    Tarron Jackson
    – Neck
    Luke Gifford
    – Knee
    Curtis Robinson
    – Knee
    Austen Pleasants
    – Gameday Inactive
    Jake Brendel
    – Hamstring
    A.Dillard
    – Undisclosed
    Isaac Alarcon
    – Suspension
    Colton McKivitz
    – Calf
    Trent Williams
    – Knee
    Spencer Burford
    – Knee
    Connor Colby
    – Gameday Inactive
    Dominick Puni
    – Knee
    Ben Bartch
    – Undisclosed
    Trent Taylor
    – Undisclosed
    George Kittle
    – Hamstring
    Mason Pline
    – Undisclosed
    Kevin Givens
    – Pectoral
    Sam Okuayinonu
    – Shoulder
    Jordan Elliott
    – Ankle
    Kalia Davis
    – Groin
    Yetur Gross-Matos
    – Undisclosed
    Alfred Collins
    – Knee
    Nick Bosa
    – Neck
    Mykel Williams
    – Knee
    CJ West
    – Knee
    Will Johnson
    – Groin
    Kyler Murray
    – Illness
    Mack Wilson Sr.
    – Ankle
    Budda Baker
    – Hamstring
    Greg Dortch
    – Collarbone
    Baron Browning
    – Concussion
    James Conner
    – Ankle
    BJ Ojulari
    – Undisclosed
    J.Sweat
    – Ankle
    Blake Gillikin
    – Back
    Kei'Trel Clark
    – Gameday Inactive
    Michael Wilson
    – Foot
    Quez Watkins
    – Undisclosed
    Max Melton
    – Hamstring
    Zay Jones
    – Knee
    Marvin Harrison Jr.
    – Concussion
    DeeJay Dallas
    – Gameday Inactive
    Garrett Williams
    – Knee
    Sean Murphy-Bunting
    – Knee
    Starling Thomas V
    – Knee
    Zaven Collins
    – Hand
    Jammie Robinson
    – Gameday Inactive
    Akeem Davis-Gaither
    – Elbow
    Elijah Jones
    – Gameday Inactive
    Denzel Burke
    – Knee
    Darren Hall
    – Ankle
    Emari Demercado
    – Ankle
    Joey Blount
    – Neck
    Trey Benson
    – Knee
    Jalen Thompson
    – Hamstring
    Bam Knight
    – Gameday Inactive
    Kitan Crawford
    – Ankle
    Jaylon Jones
    – Hamstring
    Dadrion Taylor-Demerson
    – Ankle
    Owen Pappoe
    – Quadricep
    Cody Simon
    – Concussion
    J.J. Russell
    – Concussion
    Xavier Thomas
    – Gameday Inactive
    Dante Stills
    – Heel
    Darius Robinson
    – Chest
    Hayden Conner
    – Gameday Inactive
    Jon Gaines II
    – Thumb
    Evan Brown
    – Hamstring
    Jeremiah Byers
    – Gameday Inactive
    Kelvin Beachum
    – Knee
    Valentin Senn
    – Neck
    Paris Johnson Jr.
    – Knee
    Hjalte Froholdt
    – Elbow
    Jonah Williams
    – Foot
    Christian Jones
    – Knee
    Josh Fryar
    – Gameday Inactive
    PJ Mustipher
    – Gameday Inactive
    Simi Fehoko
    – Concussion
    Travis Vokolek
    – Gameday Inactive
    Andre Baccellia
    – Arm
    Elijah Higgins
    – Illness
    Trishton Jackson
    – Thumb
    Tip Reiman
    – Foot
    Xavier Weaver
    – Gameday Inactive
    L.J. Collier
    – Knee
    Bilal Nichols
    – Undisclosed
    Dalvin Tomlinson
    – Knee
    Elijah Simmons
    – Gameday Inactive
    Walter Nolen III
    – Calf
    Justin Jones
    – Knee

    Current Betting Odds

    • Spread: Cardinals favored at 1.5
    • Total (Over/Under): 44.5
    • Moneyline Odds: 49ers -123 , Cardinals +103

    Recent Matches

    49ers
    Cardinals
    Date Vs Result Score
    09/14/2025 Saints win 21 : 26
    09/07/2025 Seahawks win 13 : 17
    08/23/2025 Chargers win 30 : 23
    08/16/2025 Raiders win 19 : 22
    08/09/2025 Broncos loss 9 : 30
    01/05/2025 Cardinals loss 47 : 24
    12/30/2024 Lions loss 34 : 40
    12/22/2024 Dolphins loss 29 : 17
    12/12/2024 Rams loss 6 : 12
    12/08/2024 Bears win 38 : 13
    W - 5
    L - 5
    Date Vs Result Score
    09/14/2025 Panthers win 27 : 22
    09/07/2025 Saints win 13 : 20
    08/23/2025 Raiders win 20 : 10
    08/16/2025 Broncos loss 27 : 7
    08/09/2025 Chiefs win 20 : 17
    01/05/2025 49ers win 47 : 24
    12/28/2024 Rams loss 13 : 9
    12/22/2024 Panthers loss 36 : 30
    12/15/2024 Patriots win 30 : 17
    12/08/2024 Seahawks loss 18 : 30
    W - 6
    L - 4

    Who Wins: our Prediction

    Based on statistical analysis, we see the 49ers at a win probability of 47%, while the Cardinals have a propability of 53% to win.

    Find the best Futures for 49ers vs Cardinals

    Statistics

    Want Even More Picks To Profit From?
    Try PromoGuy+ For Free
    All Betting Tips
    Money Line -116 FanDuel +100 BetMGM
    Spread -1.5 -105 DraftKings 1.0 -110 BetMGM
    Over/Under -102 FanDuel DraftKings
    Money Line +176 FanDuel -200 BetMGM
    Spread 3.5 -102 FanDuel -3.5 -105 BetMGM
    Over/Under -108 DraftKings DraftKings
    Money Line +130 DraftKings -152 FanDuel
    Spread 3.0 -115 BetMGM -3.0 -102 DraftKings
    Over/Under -108 DraftKings DraftKings
    Money Line +455 DraftKings -592 FanDuel
    Spread 10.0 -105 BetMGM -10.5 -104 FanDuel
    Over/Under -110 BetMGM DraftKings
    Money Line -120 BetMGM +106 FanDuel
    Spread -1.5 -105 BetMGM 1.5 -110 FanDuel
    Over/Under -108 FanDuel DraftKings
    Money Line -180 DraftKings +154 BetMGM
    Spread -3.5 +100 DraftKings 3.5 -115 BetMGM
    Over/Under -110 FanDuel DraftKings
    Money Line +135 BetMGM -150 Fanatics
    Spread 2.5 -102 FanDuel -3.0 -102 BetMGM
    Over/Under -108 FanDuel DraftKings
    Money Line -1299 Fanatics +950 DraftKings
    Spread -14.5 +100 FanDuel 14.0 -105 Fanatics
    Over/Under -105 Fanatics DraftKings
    Money Line -375 BetMGM +320 DraftKings
    Spread -7.5 -105 BetMGM 7.5 -105 BetMGM
    Over/Under -105 DraftKings DraftKings
    Money Line -190 BetMGM +164 DraftKings
    Spread -3.5 -105 DraftKings 3.5 -110 Fanatics
    Over/Under -105 FanDuel DraftKings
    Money Line +187.5 FanDuel -218 DraftKings
    Spread 4.5 -114 FanDuel -4.5 -105 DraftKings
    Over/Under -102 DraftKings DraftKings
    Money Line +370 DraftKings -450 Fanatics
    Spread 8.5 -105 FanDuel -8.5 -108 DraftKings
    Over/Under -108 FanDuel DraftKings
    Money Line +300 BetMGM -350 FanDuel
    Spread 7.0 -102 FanDuel -7.5 +100 DraftKings
    Over/Under -108 DraftKings DraftKings
    Money Line +810 FanDuel -1000 BetMGM
    Spread 13.5 -106 FanDuel -13.5 -105 DraftKings
    Over/Under -105 DraftKings DraftKings
    Money Line -115 Fanatics +102 FanDuel
    Spread -1.5 -105 DraftKings 1.5 -110 FanDuel
    Over/Under -110 FanDuel DraftKings
    Latest News
    PromoGuy Daily +EV Picks: November 5, 2025
      The 2025 NFL trade deadline has officially ...
    PromoGuy Daily +EV Picks: November 4, 2025
    📅 What’s Going On in Sports Today The ...
    PromoGuy Daily +EV Picks: November 3, 2025
    Week 9 of the NFL season brought chaos, ...
    PromoGuy Daily +EV Picks: October 31, 2025
    Lamar Jackson made his long-awaited return Thursday night, ...
    PromoGuy Daily +EV Picks: October 30, 2025
      The Toronto Blue Jays are one win ...
    Sports Betting
    Daily Fantasy Sports
    Online Casino
    Free To Play

    Make $1,200 Monthly Profits with Sports Betting

    • bullet-checkmarkDaily picks from betting experts on odds boosts and casino promos
    • bullet-checkmark$1,200+ in average monthly profits with a 20% ROI
    PromoGuy logo

    Go Pro! Claim An Exclusive $5 Off PromoGuy Plus Discord

    Follow our free plays
    Choose your preferred channel:
    Get started
    Twitter
    Reddit
    Discord
    Wanna make consistent profits with online sports betting?
    Most Popular Guides
    promoguy.us is available in the following countries:
    en_US
    US
    Promoguy US
    Best Alternatives
    Trending Articles
    About PromoGuy

    21+ and present in OH. Gambling Problem? Call 1-800-GAMBLER.

    This site is using Cloudflare and adheres to the Google Safe Browsing Program. We adapted Google's Privacy Guidelines to keep your data safe at all times.
    CloudflareSSL