Colts vs Cardinals NFL Week 6 – Match Preview & Live Updates Sunday, October 12, 2025

National Football League
Colts
Home
12/10/2025
1:00pm
Cardinals
Away

Colts vs. Cardinals: Detailed Breakdown

Cardinals– is set for Sunday, October 12, 2025 at 1:00 pm ET. Sportsbooks list Point Spread Cardinals and Total 46.5 M/L: Cardinals -435, Colts +337 is available. Lines are posted across books.

Money Line -426 Fanatics +375 BetMGM
Spread -8.5 -108 DraftKings 9.0 -110 BetMGM
Over/Under +102 DraftKings DraftKings

Matchup Overview

  • Teams: Colts vs Cardinals
  • Date: Sunday, October 12, 2025
  • Time: 01:00 pm ET
  • Venue: Lucas Oil Stadium

Where To Watch Colts vs Cardinals on Sunday

The match will be broadcast by FOX.

Injuries

Colts
Cardinals
Josh Downs
– Hamstring
D.J. Montgomery
– Undisclosed
Spencer Shrader
– Knee
Anthony Richardson Sr.
– Eye
Anthony Gould
– Illness
Charvarius Ward
– Concussion
Rigoberto Sanchez
– Personal
Adonai Mitchell
– Gameday Inactive
Michael Pittman Jr.
– Glute
Alec Pierce
– Knee
Riley Leonard
– Gameday Inactive
Ashton Dulin
– Concussion
Daniel Jones
– Fibula
Nick Cross
– Hip
DJ Giddens
– Gameday Inactive
Kenny Moore II
– Calf
Khalil Herbert
– Gameday Inactive
Justin Walley
– Knee
JuJu Brents
– Gameday Inactive
Hunter Wohler
– Foot
Tyler Goodson
– Elbow
Samuel Womack III
– Gameday Inactive
Johnathan Edwards
– Gameday Inactive
Salvon Ahmed
– Ankle
Daniel Scott
– Knee
Chris Lammons
– Foot
Jaylon Jones
– Hamstring
Zaire Franklin
– Ankle
Liam Anderson
– Undisclosed
Joe Bachie
– Quadricep
Maddux Trujillo
– Undisclosed
Kwity Paye
– Groin
Samson Ebukam
– Back
Jacob Phillips
– Bicep
Quenton Nelson
– Wrist
Jaylon Carlies
– Ankle
Austin Ajiake
– Throat
Cameron McGrone
– Achilles
Tanor Bortolini
– Concussion
Danny Pinter
– Rib
Luke Tenuta
– Gameday Inactive
Dalton Tucker
– Shoulder
Matt Goncalves
– Personal
Braden Smith
– Groin
Blake Freeland
– Leg
Jack Wilson
– Undisclosed
Bernhard Raimann
– Illness
Jelani Woods
– Gameday Inactive
Tyler Warren
– Toe
Drew Ogletree
– Neck
Will Mallory
– Gameday Inactive
Grover Stewart
– Biceps
JT Tuimoloau
– Gameday Inactive
Neville Gallimore
– Knee
Tyquan Lewis
– Oblique
Laiatu Latu
– Hamstring
Eric Johnson II
– Gameday Inactive
DeForest Buckner
– Back
Will Johnson
– Groin
Kyler Murray
– Illness
Mack Wilson Sr.
– Ankle
Budda Baker
– Hamstring
Greg Dortch
– Collarbone
Baron Browning
– Concussion
James Conner
– Ankle
BJ Ojulari
– Undisclosed
J.Sweat
– Ankle
Blake Gillikin
– Back
Kei'Trel Clark
– Gameday Inactive
Michael Wilson
– Foot
Quez Watkins
– Undisclosed
Max Melton
– Hamstring
Zay Jones
– Knee
Marvin Harrison Jr.
– Concussion
DeeJay Dallas
– Gameday Inactive
Garrett Williams
– Knee
Sean Murphy-Bunting
– Knee
Starling Thomas V
– Knee
Zaven Collins
– Hand
Jammie Robinson
– Gameday Inactive
Akeem Davis-Gaither
– Elbow
Elijah Jones
– Gameday Inactive
Denzel Burke
– Knee
Darren Hall
– Ankle
Emari Demercado
– Ankle
Joey Blount
– Neck
Trey Benson
– Knee
Jalen Thompson
– Hamstring
Bam Knight
– Gameday Inactive
Kitan Crawford
– Ankle
Jaylon Jones
– Hamstring
Dadrion Taylor-Demerson
– Ankle
Owen Pappoe
– Quadricep
Cody Simon
– Concussion
J.J. Russell
– Concussion
Xavier Thomas
– Gameday Inactive
Dante Stills
– Heel
Darius Robinson
– Chest
Hayden Conner
– Gameday Inactive
Jon Gaines II
– Thumb
Evan Brown
– Hamstring
Jeremiah Byers
– Gameday Inactive
Kelvin Beachum
– Knee
Valentin Senn
– Neck
Paris Johnson Jr.
– Knee
Hjalte Froholdt
– Elbow
Jonah Williams
– Foot
Christian Jones
– Knee
Josh Fryar
– Gameday Inactive
PJ Mustipher
– Gameday Inactive
Simi Fehoko
– Concussion
Travis Vokolek
– Gameday Inactive
Andre Baccellia
– Arm
Elijah Higgins
– Illness
Trishton Jackson
– Thumb
Tip Reiman
– Foot
Xavier Weaver
– Gameday Inactive
L.J. Collier
– Knee
Bilal Nichols
– Undisclosed
Dalvin Tomlinson
– Knee
Elijah Simmons
– Gameday Inactive
Walter Nolen III
– Calf
Justin Jones
– Knee

Current Betting Odds

  • Spread: Cardinals favored at 8
  • Total (Over/Under): 46.5
  • Moneyline Odds: Colts -435 , Cardinals +337

Recent Matches

Colts
Cardinals
Date Vs Result Score
10/05/2025 Raiders win 40 : 6
09/28/2025 Rams loss 27 : 20
09/21/2025 Titans win 20 : 41
09/14/2025 Broncos win 29 : 28
09/07/2025 Dolphins win 33 : 8
08/23/2025 Bengals win 14 : 41
08/16/2025 Packers loss 19 : 23
08/07/2025 Ravens loss 24 : 16
01/05/2025 Jaguars win 26 : 23
12/29/2024 Giants loss 45 : 33
W - 6
L - 4
Date Vs Result Score
10/05/2025 Titans loss 21 : 22
09/25/2025 Seahawks loss 20 : 23
09/21/2025 49ers loss 16 : 15
09/14/2025 Panthers win 27 : 22
09/07/2025 Saints win 13 : 20
08/23/2025 Raiders win 20 : 10
08/16/2025 Broncos loss 27 : 7
08/09/2025 Chiefs win 20 : 17
01/05/2025 49ers win 47 : 24
12/28/2024 Rams loss 13 : 9
W - 5
L - 5

Who Wins: our Prediction

Based on statistical analysis, we see the Colts at a win probability of 22%, while the Cardinals have a propability of 78% to win.

Find the best Futures for Colts vs Cardinals

Statistics

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Money Line -116 FanDuel +100 BetMGM
Spread -1.5 -105 DraftKings 1.0 -110 BetMGM
Over/Under -102 FanDuel DraftKings
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Spread 3.5 -102 FanDuel -3.5 -105 BetMGM
Over/Under -108 DraftKings DraftKings
Money Line +130 DraftKings -152 FanDuel
Spread 3.0 -115 BetMGM -3.0 -102 DraftKings
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Spread 10.0 -105 BetMGM -10.5 -104 FanDuel
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Spread -1.5 -105 BetMGM 1.5 -110 FanDuel
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Money Line -180 DraftKings +154 BetMGM
Spread -3.5 +100 DraftKings 3.5 -115 BetMGM
Over/Under -110 FanDuel DraftKings
Money Line +135 BetMGM -150 Fanatics
Spread 2.5 -102 FanDuel -3.0 -102 BetMGM
Over/Under -108 FanDuel DraftKings
Money Line -1299 Fanatics +950 DraftKings
Spread -14.5 +100 FanDuel 14.0 -105 Fanatics
Over/Under -105 Fanatics DraftKings
Money Line -375 BetMGM +320 DraftKings
Spread -7.5 -105 BetMGM 7.5 -105 BetMGM
Over/Under -105 DraftKings DraftKings
Money Line -190 BetMGM +164 DraftKings
Spread -3.5 -105 DraftKings 3.5 -110 Fanatics
Over/Under -105 FanDuel DraftKings
Money Line +187.5 FanDuel -218 DraftKings
Spread 4.5 -114 FanDuel -4.5 -105 DraftKings
Over/Under -102 DraftKings DraftKings
Money Line +370 DraftKings -450 Fanatics
Spread 8.5 -105 FanDuel -8.5 -108 DraftKings
Over/Under -108 FanDuel DraftKings
Money Line +300 BetMGM -350 FanDuel
Spread 7.0 -102 FanDuel -7.5 +100 DraftKings
Over/Under -108 DraftKings DraftKings
Money Line +810 FanDuel -1000 BetMGM
Spread 13.5 -106 FanDuel -13.5 -105 DraftKings
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Money Line -115 Fanatics +102 FanDuel
Spread -1.5 -105 DraftKings 1.5 -110 FanDuel
Over/Under -110 FanDuel DraftKings
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