Cardinals– is set for Sunday, October 12, 2025 at 1:00 pm ET. Sportsbooks list Point Spread Cardinals and Total 46.5 M/L: Cardinals -435, Colts +337 is available. Lines are posted across books.
Money Line-426+375
Spread
-8.5
-108
9.0
-110
Over/Under
+102
-122
Matchup Overview
Teams: Colts vs Cardinals
Date: Sunday, October 12, 2025
Time: 01:00 pm ET
Venue: Lucas Oil Stadium
Where To Watch Colts vs Cardinals on Sunday
The match will be broadcast by FOX.
Injuries
Colts
Cardinals
Josh Downs
– Hamstring
D.J. Montgomery
– Undisclosed
Spencer Shrader
– Knee
Anthony Richardson Sr.
– Eye
Anthony Gould
– Illness
Charvarius Ward
– Concussion
Rigoberto Sanchez
– Personal
Adonai Mitchell
– Gameday Inactive
Michael Pittman Jr.
– Glute
Alec Pierce
– Knee
Riley Leonard
– Gameday Inactive
Ashton Dulin
– Concussion
Nick Cross
– Hip
DJ Giddens
– Gameday Inactive
Kenny Moore II
– Calf
Khalil Herbert
– Gameday Inactive
Justin Walley
– Knee
JuJu Brents
– Gameday Inactive
Hunter Wohler
– Foot
Tyler Goodson
– Elbow
Samuel Womack III
– Gameday Inactive
Johnathan Edwards
– Gameday Inactive
Salvon Ahmed
– Ankle
Daniel Scott
– Knee
Jaylon Jones
– Hamstring
Zaire Franklin
– Ankle
Liam Anderson
– Undisclosed
Joe Bachie
– Quadricep
Maddux Trujillo
– Undisclosed
Kwity Paye
– Groin
Samson Ebukam
– Back
Jacob Phillips
– Bicep
Jaylon Carlies
– Ankle
Austin Ajiake
– Throat
Luke Tenuta
– Gameday Inactive
Matt Goncalves
– Personal
Braden Smith
– Groin
Blake Freeland
– Leg
Jack Wilson
– Pectoral
Bernhard Raimann
– Illness
Jelani Woods
– Gameday Inactive
Tyler Warren
– Toe
Will Mallory
– Gameday Inactive
Grover Stewart
– Biceps
JT Tuimoloau
– Gameday Inactive
Tyquan Lewis
– Oblique
Laiatu Latu
– Hamstring
Eric Johnson II
– Gameday Inactive
DeForest Buckner
– Back
Will Johnson
– Groin
Kyler Murray
– Illness
Mack Wilson Sr.
– Ankle
Budda Baker
– Hamstring
Greg Dortch
– Collarbone
James Conner
– Ankle
BJ Ojulari
– Undisclosed
Blake Gillikin
– Back
Kei'Trel Clark
– Gameday Inactive
Michael Wilson
– Foot
Quez Watkins
– Undisclosed
Max Melton
– Hamstring
Zay Jones
– Knee
Marvin Harrison Jr.
– Concussion
DeeJay Dallas
– Gameday Inactive
Garrett Williams
– Knee
Sean Murphy-Bunting
– Knee
Starling Thomas V
– Knee
Zaven Collins
– Hand
Jammie Robinson
– Gameday Inactive
Akeem Davis-Gaither
– Elbow
Elijah Jones
– Gameday Inactive
Denzel Burke
– Knee
Darren Hall
– Ankle
Emari Demercado
– Ankle
Joey Blount
– Neck
Trey Benson
– Knee
Bam Knight
– Gameday Inactive
Kitan Crawford
– Ankle
Jaylon Jones
– Hamstring
Dadrion Taylor-Demerson
– Ankle
Owen Pappoe
– Quadricep
Cody Simon
– Concussion
J.J. Russell
– Concussion
Xavier Thomas
– Gameday Inactive
Dante Stills
– Heel
Darius Robinson
– Chest
Hayden Conner
– Knee
Jon Gaines II
– Thumb
Evan Brown
– Hamstring
Kelvin Beachum
– Knee
Valentin Senn
– Undisclosed
Paris Johnson Jr.
– Knee
Jonah Williams
– Foot
Christian Jones
– Knee
Josh Fryar
– Gameday Inactive
Simi Fehoko
– Concussion
Travis Vokolek
– Gameday Inactive
Trishton Jackson
– Thumb
Tip Reiman
– Ankle
Xavier Weaver
– Gameday Inactive
L.J. Collier
– Knee
Bilal Nichols
– Undisclosed
Dalvin Tomlinson
– Knee
Walter Nolen III
– Calf
Justin Jones
– Undisclosed
Current Betting Odds
Spread: Cardinals favored at 8
Total (Over/Under): 46.5
Moneyline Odds: Colts -435 , Cardinals +337
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loss
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: 17
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: 24
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loss
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W - 5
L - 5
Who Wins: our Prediction
Based on statistical analysis, we see the Colts at a win probability of 22%, while the Cardinals have a propability of 78% to win.
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