MLB Player Props for September 22: Four Bets for Monday

Joseph Scalise

Betting Analyst

Publish Date: 09/22/2025

Fact checked by: Collin

Today is perhaps the slowest day in the entire MLB season. There are just three games on the schedule, but that doesn’t mean there aren’t plenty of betting opportunities. Each contest has several solid play props to be had.

In this article we cover our four favorite lines on the day. We look at each one in-depth by covering the bet, the statistics and data behind it, as well as why we like it over similar lines.

1. Ronald Acuna Jr to Hit a Home Run vs. Nationals (+400)

Home runs are always a fickle mistress. Even so, we like Ronald Acuna Jr. as our first go-deep pick of the day. The slugger is having a down year by his standards, with 18 long balls on the season, but he finds himself in a favorable position on Monday against the Nationals.

Washington will start MacKenzie Gore. The lefty has had a rocky season from an ERA perspective (4.00) and can’t find ways to win games. In addition, he allowed both a 10.2 percent barrel rate and a 44.0 percent hard-hit rate on the season. He’s decent when it comes to strikeouts, but is much worse versus right-handed batters than lefties.

That’s then compounded by Acuna’s recent success. After going down in the lineup, he’s been on fire. He’s recorded a hit in 9 of his last 13 games. He also has six mult-hit contests in that span and has knocked in three home runs. That, combined with Gore’s inconsistency, makes this an opportunity for him to get one out.

2. Rafael Devers to Hit a Home Run vs Cardinals (+400)

Devers is a strong hitter with a lot of power potential. He’s knocked 32 home runs this season, and there’s a strong chance he could go yard again on Monday. His power, mixed with several external factors, make this a strong bet for those seeking a bigger payout.

The first reason we like Devers is that the Cardinals will start Michael McGreevy (4.08 ERA). The righty has struggled against left-handers this season (14.7 percent strikeout rate and 1.47 home runs per nine innings), and hasn’t been the most consistent on the mound. In fact, Devers took him deep just two weeks ago.

Devers also has strong power metrics on the season. His 15.4 percent barrel rate is in the 94th percentile, and his 55.8 percent hard hit rate is in the 97th percentile. He strikes out a lot, but McGreevy is not known for making batters miss. That could give Devers a chance here.

3. Fernando Tatis Jr. Over 1.5 Bases vs. Brewers (+137)

Fernando Tatis Jr. is having a dip in average compared to last season, but his home runs and RBIs are both up. He’s also found ways to get on base and is always a threat at the plate. That alone makes him a good pick for this line.

The lead-off hitter projects at the 9th-best bat in the majors and plays at home on Monday. Petco Park has the shortest average fence height in the entire league. The weather also has the second best hitting conditions in the majors, given both temperature and humidity.

Tatis will have to face Freddy Peralta (2.65 ERA), who has been lights out lately. However, while he doesn’t give up runs, Peralta has surrendered four or more hits in four of his last ten games. That, combined with Tatis’ ability to find gaps in the outfield, could net him a double at some point. He could see success against the Brewers bullpen as well.

4. Nick Pivetta Over 17.5 Outs Recorded (-125)

We round out our bets today with a pitching line. Nick Pivetta is a strong starter with a good arm. He’s posting a 2.81 ERA on the season and has the ability to make just about anyone whiff. That puts him in a great position for another solid start.

The righty had a rough last outing, where he surrendered 3 runs and seven hits to the Mets, but that was a fluke in what has otherwise been a great year. He’s recorded more than 17.5 outs in eight of his last ten starts. He’s also only given up more than two earned runs twice in that span.

Though the Brewers continue to be one of the best hitting teams in baseball, Pivetta has faced many of the league's top teams with great success. The Padres also trust him. He stayed in the game and recorded 18 outs against the Rockies (where he gave up seven hits) and the Red Sox (where he gave up five runs). That makes this a bet we trust.

All lines courtesy of DraftKings and BetMGM.